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Dpyd
Gene Detail
 Symbol
Name
ID
Dpyd
dihydropyrimidine dehydrogenase
MGI:2139667
Synonyms DPD, E330028L06Rik
Feature Type protein coding gene
Genetic Map
Chromosome 3
51.96 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr3:118562129-119432918 bp, + strand
From VEGA annotation of GRCm38

  870790 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:85  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Dpyd

Human
homologs
Human Homolog DPYD, dihydropyrimidine dehydrogenase
NCBI Gene ID 1806
neXtProt AC  NX_Q12882
Human Synonyms  DHP, DHPDHASE, DPD
Human Chr (Location)  1p22; chr1:97077743-97921059 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human DPYD
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Gene trapped(1) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
Interactions
Dpyd interacts with 200 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (34 annotations)
Process circadian rhythm, oxidation-reduction process, ...
Component cytoplasm, cytosol
Function 4 iron, 4 sulfur cluster binding, catalytic activity, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (320)    Tissues (167)    Images (43)
Theiler Stages: 12, 13, 14, 22, 23
Assay TypeResults
RNA in situ 320
cDNA source data(27)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(27) cDNA(27)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000025956 (Evidence)
Ensembl Gene ModelENSMUSG00000033308 (Evidence)
Entrez Gene99586 (Evidence)
UniGene27907
DFCITC1581447
DoTSDT.40166040, DT.91403853, DT.97366903
NIA Mouse Gene IndexU003791
EC1.3.1.2
Consensus CDS ProjectCCDS17797.1
International Mouse Knockout Project StatusDpyd
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000025956 VEGA Gene Model | MGI Sequence Detail 870790 C57BL/6J ±  kb
transcript OTTMUST00000064012 VEGA | MGI Sequence Detail 4486 Not Applicable 
polypeptide OTTMUSP00000031746 VEGA | MGI Sequence Detail 1025 Not Applicable 

For the selected sequences
All sequences(40) RefSeq(4) UniProt(6)
Polymorphisms SNPs within 2kb(3948 from dbSNP Build 137)    SNPs within 2kb including multiple locations(3954)
Protein-related
information
ResourceIDDescription
InterPro IPR017900 4Fe-4S ferredoxin, iron-sulphur binding, conserved site
InterPro IPR017896 4Fe-4S ferredoxin-type, iron-sulpur binding domain
InterPro IPR013785 Aldolase-type TIM barrel
InterPro IPR009051 Alpha-helical ferredoxin
InterPro IPR012135 Dihydroorotate dehydrogenase, class 1/ 2
InterPro IPR005720 Dihydroorotate dehydrogenase domain
Protein Ontology PR:000006678 dihydropyrimidine dehydrogenase [NADP(+)]
References (Earliest) J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(38)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/26/2014
MGI 5.19
The Jackson Laboratory