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Arfgef2
Gene Detail
Symbol

Name
ID
Arfgef2
ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited)
MGI:2139354
Synonyms
BIG2, E230011G24Rik
Feature Type
protein coding gene
Genetic Map
Chromosome 2
87.22 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr2:166805588-166898052 bp, + strand
From VEGA annotation of GRCm38

  92465 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:111880  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: ARFGEF2
Protein SuperFamily: brefeldin A-inhibited guanine nucleotide-exchange protein
Gene Tree: Arfgef2

Human
homologs
ARFGEF2, ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited)
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 10564
neXtProt AC: NX_Q9Y6D5

Human Synonyms: BIG2, dJ1164I10.1, PVNH2

Human Chr (Location): 20q13.13; chr20:48921721-49036693 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human ARFGEF2

Mutations,
alleles, and
phenotypes
All mutations/alleles(30) : Gene trapped(29) Targeted(1)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit exencephaly, midline gut closure defects, periventricular and subependymal heterotopia, and impaired neuronal migration.
 
Interactions
Arfgef2 interacts with 392 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (38 annotations)
Process endomembrane system organization, endosome organization, ...
Component asymmetric synapse, axonemal microtubule, ...
Function ARF guanyl-nucleotide exchange factor activity, GABA receptor binding, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (42)    Tissues (30)    Images (18)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 8
RNA in situ 34
cDNA source data(14)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase arfgef2    NEW 
Molecular
reagents
All nucleic(14) cDNA(14)
Microarray probesets(10)
Other database
links
VEGA Gene Model OTTMUSG00000001162 (Evidence)
Ensembl Gene Model ENSMUSG00000074582 (Evidence)
Entrez Gene 99371 (Evidence)
DFCI TC1597614, TC1597745, TC1741883
DoTS DT.55241439, DT.91335384, DT.94267766
NIA Mouse Gene Index U002843
Consensus CDS Project CCDS38335.1
International Mouse Phenotyping Consortium Status Arfgef2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000001162 VEGA Gene Model | MGI Sequence Detail 92465 C57BL/6J ±  kb
transcript OTTMUST00000002258 VEGA | MGI Sequence Detail 8770 Not Applicable 
polypeptide OTTMUSP00000001103 VEGA | MGI Sequence Detail 1792 Not Applicable 

For the selected sequences
All sequences(49) RefSeq(8) UniProt(4)
Polymorphisms
SNPs within 2kb(470 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR011989 Armadillo-like helical
InterPro IPR016024 Armadillo-type fold
InterPro IPR015403 Domain of unknown function DUF1981, SEC7 associated
InterPro IPR000904 SEC7-like
InterPro IPR023394 SEC7-like, alpha orthogonal bundle
Protein Ontology PR:000004210 brefeldin A-inhibited guanine nucleotide-exchange protein 2
References
(Earliest) J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
(Latest) J:187673 Zhang J, et al., Brefeldin A-inhibited Guanine Exchange Factor 2 Regulates Filamin A Phosphorylation and Neuronal Migration. J Neurosci. 2012 Sep 5;32(36):12619-29
All references(37)
Other
accession IDs
MGI:2138973, MGI:2443566

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory