Arfgef2
Gene Detail

Symbol Name ID

Arfgef2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) MGI:2139354

Synonyms

BIG2, E230011G24Rik

Feature Type

protein coding gene

Genetic Map

Chromosome 2

87.22 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr2:166805588-166898052 bp, + strand From VEGA annotation of GRCm38   92465 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:111880  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: brefeldin A-inhibited guanine nucleotide-exchange protein
Gene Tree: Arfgef2

Human homologs

Human Homolog		ARFGEF2, ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited)
NCBI Gene ID		10564
neXtProt AC		NX_Q9Y6D5
Human Synonyms		BIG2, dJ1164I10.1, PVNH2
Human Chr (Location)		20q13.13; chr20:47538275-47653230 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human ARFGEF2

Alleles and phenotypes

All alleles(30) : Targeted(1) Gene trapped(29)
 

Mice homozygous for a knock-out allele exhibit exencephaly, midline gut closure defects, periventricular and subependymal heterotopia, and impaired neuronal migration.

 

Gene Ontology (GO) classifications

All GO classifications: (37 annotations)

Process	endomembrane system organization, endosome organization, ...
Component	asymmetric synapse, axonemal microtubule, ...
Function	ARF guanyl-nucleotide exchange factor activity, GABA receptor binding, ...

External Resources: FuncBase

Expression

Literature Summary: (3 records)
Data Summary: Results (42)    Tissues (26)    Images (18)
Theiler Stages: 20, 22, 24, 25, 28

Assay Type	Results
Immunohistochemistry	8
RNA in situ	34

cDNA source data(75)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(75) cDNA(75)
Microarray probesets(10)

Other database links

VEGA Gene Model	OTTMUSG00000001162 (Evidence)
Ensembl Gene Model	ENSMUSG00000074582 (Evidence)
Entrez Gene	99371 (Evidence)
UniGene	297192
DFCI	TC1597614, TC1597745, TC1741883
DoTS	DT.55241439, DT.91335384, DT.94267766
NIA Mouse Gene Index	U002843
Consensus CDS Project	CCDS38335.1
International Mouse Knockout Project Status	Arfgef2

Sequences

Length	Strain/Species
genomic	OTTMUSG00000001162	VEGA Gene Model | MGI Sequence Detail	92465	C57BL/6J
transcript	OTTMUST00000002258	VEGA | MGI Sequence Detail	8770	Not Applicable
polypeptide	OTTMUSP00000001103	VEGA | MGI Sequence Detail	1792	Not Applicable

All sequences(43) RefSeq(2) UniProt(4)

Polymorphisms

SNPs(383 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR011989	Armadillo-like helical
InterPro	IPR016024	Armadillo-type fold
InterPro	IPR015403	Domain of unknown function DUF1981, SEC7 associated
InterPro	IPR000904	SEC7-like
InterPro	IPR023394	SEC7-like, alpha orthogonal bundle
Protein Ontology	PR:000004210	brefeldin A-inhibited guanine nucleotide-exchange protein 2

References

(Earliest) J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
(Latest) J:187673 Zhang J, et al., Brefeldin A-inhibited Guanine Exchange Factor 2 Regulates Filamin A Phosphorylation and Neuronal Migration. J Neurosci. 2012 Sep 5;32(36):12619-29
All references(39)

Other accession IDs

MGI:2138973, MGI:2443566