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Hrh3 Gene Detail
Summary
  • Symbol
    Hrh3
  • Name
    histamine receptor H3
  • Synonyms
    Eae8
  • Feature Type
    protein coding gene
  • IDs
    MGI:2139279
    NCBI Gene: 99296
  • Gene Overview
    MyGene.info: HRH3
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr2:180099465-180104488 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      5024 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 102.62 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    HRH3, histamine receptor H3
  • Vertebrate Orthologs
    10
  • Human Ortholog
    HRH3, histamine receptor H3
    Orthology source: HomoloGene, HGNC
  • Synonyms
    GPCR97, HH3R
  • Links
    NCBI Gene ID: 11255
    neXtProt AC: NX_Q9Y5N1
    UniProt: Q9Y5N1

  • Chr Location
    20q13.33; chr20:62213845-62220267 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    26 phenotypes from 4 alleles in 6 genetic backgrounds
    21 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygotes for a targeted null mutation exhibit reduced locomotor activity and body temperature, and attenuated behavioral responses to the drugs thioperamide, methamphetamine, and scopolamine.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000016256 VEGA Gene Model | MGI Sequence Detail 5024 C57BL/6J ±  kb
    transcript OTTMUST00000092757 VEGA | MGI Sequence Detail 1401 Not Applicable  
    polypeptide OTTMUSP00000051334 VEGA | MGI Sequence Detail 466 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      17 from dbSNP Build 142
    Protein
    Information
    less
    • UniProt
      11 Sequences
    • InterPro Domains
      IPR017452 GPCR, rhodopsin-like, 7TM
      IPR000276 G protein-coupled receptor, rhodopsin-like
      IPR003980 Histamine H3 receptor
    Molecular
    Reagents
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    • All nucleic 10
      Genomic 2
      cDNA 8

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:1309474
    References
    more
    • Summaries
      All 47
      Developmental Gene Expression 1
      Gene Ontology 4
      Phenotypes 21
    • Earliest
      J:29171 Baker D, et al., Genetic analysis of experimental allergic encephalomyelitis in mice. J Immunol. 1995 Oct 15;155(8):4046-51
    • Latest
      J:247533 Rapanelli M, et al., The Histamine H3 Receptor Differentially Modulates Mitogen-activated Protein Kinase (MAPK) and Akt Signaling in Striatonigral and Striatopallidal Neurons. J Biol Chem. 2016 Sep 30;291(40):21042-21052

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    07/31/2018
    MGI 6.12
    The Jackson Laboratory