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Hrh3 Gene Detail
Summary
  • Symbol
    Hrh3
  • Name
    histamine receptor H3
  • Synonyms
    Eae8
  • Feature Type
    protein coding gene
  • IDs
    MGI:2139279
    NCBI Gene: 99296
  • Gene Overview
    MyGene.info: HRH3
Location & Maps
more
  • Sequence Map
    Chr2:180099465-180104488 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      5024 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    HRH3, histamine receptor H3
  • Vertebrate Orthologs
    10
  • Human Ortholog
    HRH3, histamine receptor H3
    Orthology source: HomoloGene
  • Synonyms
    GPCR97, HH3R
  • Links
    NCBI Gene ID: 11255
    neXtProt AC: NX_Q9Y5N1

  • Chr Location
    20q13.33; chr20:62214766-62220278 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    27 phenotypes from 6 alleles in 7 genetic backgrounds
    20 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    8
  • QTL
    3
  • Targeted
    5
  • Incidental Mutations
    APF , CvDC
Homozygotes for a targeted null mutation exhibit reduced locomotor activity and body temperature, and attenuated behavioral responses to the drugs thioperamide, methamphetamine, and scopolamine.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016256 VEGA Gene Model | MGI Sequence Detail 5024 C57BL/6J ±  kb
transcript OTTMUST00000092757 VEGA | MGI Sequence Detail 1401 Not Applicable  
polypeptide OTTMUSP00000051334 VEGA | MGI Sequence Detail 466 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    17 from dbSNP Build 142
Protein
Information
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  • UniProt
    11 Sequences
  • Protein Ontology
    PR:000001564 histamine H3 receptor
  • InterPro Domains
    IPR017452 GPCR, rhodopsin-like, 7TM
    IPR000276 G protein-coupled receptor, rhodopsin-like
    IPR003980 Histamine H3 receptor
Molecular
Reagents
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  • All nucleic 9
    Genomic 1
    cDNA 8

    Microarray probesets 3
Other
Accession IDs
less
MGI:1309474
References
more
  • Summaries
    All 44
    Gene Ontology 4
    Phenotypes 20
  • Earliest
    J:29171 Baker D, et al., Genetic analysis of experimental allergic encephalomyelitis in mice. J Immunol. 1995 Oct 15;155(8):4046-51
  • Latest
    J:220488 Murakami M, et al., Involvement of the histamine H1 receptor in the regulation of sympathetic nerve activity. Biochem Biophys Res Commun. 2015 Mar 13;458(3):584-9

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory