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Hrh3
Gene Detail
 Symbol
Name
ID
Hrh3
histamine receptor H3
MGI:2139279
Synonyms Eae8
Feature Type protein coding gene
Genetic Map
Chromosome 2
102.62 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr2:180099465-180104488 bp, - strand
From VEGA annotation of GRCm38

  5024 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:5232  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

Protein SuperFamily: H3/H4 histamine receptor
Gene Tree: Hrh3

Human
homologs
Human Homolog HRH3, histamine receptor H3
NCBI Gene ID 11255
neXtProt AC  NX_Q9Y5N1
Human Synonyms  GPCR97, HH3R
Human Chr (Location)  20q13.33; chr20:62214961-62220267 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : QTL(3) Targeted(5)
Incidental mutations (data from APF )
 
Homozygotes for a targeted null mutation exhibit reduced locomotor activity and body temperature, and attenuated behavioral responses to the drugs thioperamide, methamphetamine, and scopolamine.
 
Interactions
Hrh3 interacts with 211 markers (Mir1b, Mir15a, Mir15b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (29 annotations)
Process cognition, drinking behavior, ...
Component cytosol, integral component of membrane, ...
Function drug binding, G-protein coupled receptor activity, ...
External Resources: FuncBase
Expression
cDNA source data(8)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(9) Genomic(1) cDNA(8)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000016256 (Evidence)
Ensembl Gene ModelENSMUSG00000039059 (Evidence)
Entrez Gene99296 (Evidence)
UniGene285360
DFCITC1584534
DoTSDT.60104533
NIA Mouse Gene IndexU023756
Consensus CDS ProjectCCDS17169.1
International Mouse Knockout Project StatusHrh3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016256 VEGA Gene Model | MGI Sequence Detail 5024 C57BL/6J ±  kb
transcript OTTMUST00000092757 VEGA | MGI Sequence Detail 1401 Not Applicable 
polypeptide OTTMUSP00000051334 VEGA | MGI Sequence Detail 466 Not Applicable 

For the selected sequences
All sequences(60) RefSeq(3) UniProt(11)
Polymorphisms SNPs within 2kb(17 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017452 GPCR, rhodopsin-like, 7TM
InterPro IPR000276 G protein-coupled receptor, rhodopsin-like
InterPro IPR003980 Histamine H3 receptor
Protein Ontology PR:000001564 histamine H3 receptor
References (Earliest) J:29171 Baker D, et al., Genetic analysis of experimental allergic encephalomyelitis in mice. J Immunol. 1995 Oct 15;155(8):4046-51
(Latest) J:210268 Yan H, et al., Histamine H3 receptors aggravate cerebral ischaemic injury by histamine-independent mechanisms. Nat Commun. 2014;5:3334
All references(46)
Other
accession IDs
MGI:1309474

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/23/2014
MGI 5.19
The Jackson Laboratory