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Slc4a11
Gene Detail
 Symbol
Name
ID
Slc4a11
solute carrier family 4, sodium bicarbonate transporter-like, member 11
MGI:2138987
Feature Type protein coding gene
Genetic Map
Chromosome 2
63.24 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr2:130684113-130697519 bp, - strand
From VEGA annotation of GRCm38

  13407 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:12931  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Slc4a11

Human
homologs
Human Homolog SLC4A11, solute carrier family 4, sodium borate transporter, member 11
NCBI Gene ID 83959
neXtProt AC  NX_Q8NBS3
Human Synonyms  BTR1, CDPD1, CHED2, dJ794I6.2, NABC1
Human Chr (Location)  20p12; chr20:3227417-3239241 (-)  GRCh38
Disease Associations  (3) Diseases Associated with Human SLC4A11
Alleles
and
phenotypes
All alleles(7) : Targeted(6) Gene trapped(1)
 
Mice homozygous for a gene trapped allele show a collapsed vestibular labyrinth, reduced brainstem auditory potentials, and altered corneal epithelium. Mice homozygous for a reporter allele show corneal endothelial dystrophy, polyuria, natriuresis, urine hypoosmolarity and impaired hearing.
 
Phenotype Images(4)
Gene Ontology
(GO)
classifications
All GO classifications: (28 annotations)
Process anion transport, bicarbonate transport, ...
Component integral component of membrane, membrane, ...
Function anion:anion antiporter activity, bicarbonate transmembrane transporter activity, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (31)    Tissues (30)    Images (4)
Theiler Stages: 23, 26, 28
Assay TypeResults
RNA in situ 31
cDNA source data(17)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(18) cDNA(17) Primer pair(1)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000015523 (Evidence)
Ensembl Gene ModelENSMUSG00000074796 (Evidence)
Entrez Gene269356 (Evidence)
UniGene441391
DFCITC1606839, TC1652220
DoTSDT.101314948, DT.91559791, DT.94263347
NIA Mouse Gene IndexU023362
Consensus CDS ProjectCCDS38244.1
International Mouse Knockout Project StatusSlc4a11
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000015523 VEGA Gene Model | MGI Sequence Detail 13407 C57BL/6J ±  kb
transcript OTTMUST00000036856 VEGA | MGI Sequence Detail 3196 Not Applicable 
polypeptide OTTMUSP00000016539 VEGA | MGI Sequence Detail 862 Not Applicable 

For the selected sequences
All sequences(43) RefSeq(10) UniProt(2)
Polymorphisms SNPs within 2kb(82 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR011531 Bicarbonate transporter, C-terminal
InterPro IPR003020 Bicarbonate transporter, eukaryotic
InterPro IPR016152 Phosphotransferase/anion transporter
InterPro IPR002178 Phosphotransferase system, phosphoenolpyruvate-dependent sugar EIIA 2
Protein Ontology PR:000015156 sodium bicarbonate transporter-like protein 11
References (Earliest) J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
(Latest) J:202267 Vilas GL, et al., Transmembrane water-flux through SLC4A11: a route defective in genetic corneal diseases. Hum Mol Genet. 2013 Nov 15;22(22):4579-90
All references(37)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory