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Slc4a11
Gene Detail
Symbol

Name
ID
Slc4a11
solute carrier family 4, sodium bicarbonate transporter-like, member 11
MGI:2138987
Feature Type
protein coding gene
Genetic Map
Chromosome 2
63.24 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr2:130684113-130697519 bp, - strand
From VEGA annotation of GRCm38

  13407 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:12931  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: SLC4A11
Gene Tree: Slc4a11

Human
homologs
SLC4A11, solute carrier family 4, sodium borate transporter, member 11
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 83959
neXtProt AC: NX_Q8NBS3

Human Synonyms: BTR1, CDPD1, CHED2, dJ794I6.2, NABC1

Human Chr (Location): 20p12; chr20:3227417-3241482 (-)  GRCh38.p2

Disease Associations: (3) Diseases Associated with Human SLC4A11

Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Gene trapped(1) Targeted(6)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for a gene trapped allele show a collapsed vestibular labyrinth, reduced brainstem auditory potentials, and altered corneal epithelium. Mice homozygous for a reporter allele show corneal endothelial dystrophy, polyuria, natriuresis, urine hypoosmolarity and impaired hearing.
 
Human Diseases Modeled in Mice Using Slc4a11 (1)    Mutations Annotated to Human Diseases (1)    Phenotype Images(4)
Interactions
Slc4a11 interacts with 66 markers (Mir22, Mir28b, Mir28c, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (33 annotations)
Process anion transport, bicarbonate transport, ...
Component cell, integral component of membrane, ...
Function anion:anion antiporter activity, anion transmembrane transporter activity, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (31)    Tissues (30)    Images (4)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 31
cDNA source data(17)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase slc4a11 ; ZFIN slc4a11    NEW 
Molecular
reagents
All nucleic(18) cDNA(17) Primer pair(1)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000015523 (Evidence)
Ensembl Gene Model ENSMUSG00000074796 (Evidence)
Entrez Gene 269356 (Evidence)
UniGene 441391
DFCI TC1652220, TC1606839
DoTS DT.91559791, DT.101314948, DT.94263347
NIA Mouse Gene Index U023362
Consensus CDS Project CCDS38244.1
International Mouse Phenotyping Consortium Status Slc4a11
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000015523 VEGA Gene Model | MGI Sequence Detail 13407 C57BL/6J ±  kb
transcript OTTMUST00000036856 VEGA | MGI Sequence Detail 3196 Not Applicable 
polypeptide OTTMUSP00000016539 VEGA | MGI Sequence Detail 862 Not Applicable 

For the selected sequences
All sequences(39) RefSeq(6) UniProt(2)
Polymorphisms
SNPs within 2kb(82 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR011531 Bicarbonate transporter, C-terminal
InterPro IPR003020 Bicarbonate transporter, eukaryotic
InterPro IPR016152 Phosphotransferase/anion transporter
InterPro IPR002178 Phosphotransferase system, phosphoenolpyruvate-dependent sugar EIIA 2
Protein Ontology PR:000015156 sodium bicarbonate transporter-like protein 11
References
(Earliest) J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
(Latest) J:214272 Han SB, et al., Mice with a targeted disruption of Slc4a11 model the progressive corneal changes of congenital hereditary endothelial dystrophy. Invest Ophthalmol Vis Sci. 2013 Sep;54(9):6179-89
All references(37)
Disease annotation references (1)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory