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Slc4a11 Gene Detail
Summary
  • Symbol
    Slc4a11
  • Name
    solute carrier family 4, sodium bicarbonate transporter-like, member 11
  • Feature Type
    protein coding gene
  • IDs
    MGI:2138987
    NCBI Gene: 269356
  • Gene Overview
    MyGene.info: SLC4A11
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:130684113-130697519 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 63.24 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    82 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2138987
protein coding gene Chr2:130684107-130697519 (-)
129S1/SvImJ MGP_129S1SvImJ_G0026515
protein coding gene Chr2:134158019-134173150 (-)
A/J MGP_AJ_G0026479
protein coding gene Chr2:128726557-128740775 (-)
AKR/J MGP_AKRJ_G0026454
protein coding gene Chr2:132442011-132455216 (-)
BALB/cJ MGP_BALBcJ_G0026491
protein coding gene Chr2:129078841-129092558 (-)
C3H/HeJ MGP_C3HHeJ_G0026234
protein coding gene Chr2:132871229-132885282 (-)
C57BL/6NJ MGP_C57BL6NJ_G0026936
protein coding gene Chr2:138306094-138319304 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0024313
protein coding gene Chr2:123467986-123481355 (-)
CAST/EiJ MGP_CASTEiJ_G0025695
protein coding gene Chr2:133132531-133145968 (-)
CBA/J MGP_CBAJ_G0026214
protein coding gene Chr2:143422060-143443911 (-)
DBA/2J MGP_DBA2J_G0026348
protein coding gene Chr2:128111567-128124762 (-)
FVB/NJ MGP_FVBNJ_G0026312
protein coding gene Chr2:126744450-126758172 (-)
LP/J MGP_LPJ_G0026453
protein coding gene Chr2:134400087-134413640 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0026332
protein coding gene Chr2:147263775-147281510 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0026991
protein coding gene Chr2:132392897-132407267 (-)
PWK/PhJ MGP_PWKPhJ_G0025431
protein coding gene Chr2:127678239-127691687 (-)
SPRET/EiJ MGP_SPRETEiJ_G0025233
protein coding gene Chr2:131533087-131547601 (-)
WSB/EiJ MGP_WSBEiJ_G0025769
protein coding gene Chr2:133323293-133336981 (-)



Homology
more
  • Human Ortholog
    SLC4A11, solute carrier family 4 member 11
  • Vertebrate Orthologs
    10
  • Human Ortholog
    SLC4A11, solute carrier family 4 member 11
    Orthology source: HGNC, HomoloGene
  • Synonyms
    BTR1, CDPD1, CHED, CHED2, dJ794I6.2, NABC1
  • Links
    NCBI Gene ID: 83959
    neXtProt AC: NX_Q8NBS3
    UniProt: Q8NBS3

  • Chr Location
    20p13; chr20:3227417-3241483 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with Slc4a11 mouse models; 2 with human SLC4A11 associations

Human Disease Mouse Models
      
IDs
View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    30 phenotypes from 3 alleles in 3 genetic backgrounds
    4 images
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a gene trapped allele show a collapsed vestibular labyrinth, reduced brainstem auditory potentials, and altered corneal epithelium. Mice homozygous for a reporter allele show corneal endothelial dystrophy, polyuria, natriuresis, urinehypoosmolarity and impaired hearing.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000074796 Ensembl Gene Model | MGI Sequence Detail 13407 C57BL/6J ±  kb
    transcript ENSMUST00000099362 Ensembl | MGI Sequence Detail 3196 Not Applicable  
    polypeptide ENSMUSP00000096963 Ensembl | MGI Sequence Detail 862 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 19
      cDNA 18
      Primer pair 1

      Microarray probesets 4
    References
    more
    • Summaries
      All 39
      Developmental Gene Expression 2
      Diseases 1
      Gene Ontology 6
      Phenotypes 12
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:246670 Liu W, et al., Vps35-deficiency impairs SLC4A11 trafficking and promotes corneal dystrophy. PLoS One. 2017;12(9):e0184906

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    12/11/2018
    MGI 6.13
    The Jackson Laboratory