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Suco Gene Detail
Summary
  • Symbol
    Suco
  • Name
    SUN domain containing ossification factor
  • Synonyms
    AI848100, Opt, osteopotentia
  • Feature Type
    protein coding gene
  • IDs
    MGI:2138346
    NCBI Gene: 226551
  • Alliance
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:161816114-161876682 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 69.95 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    368 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2138346
protein coding gene Chr1:161816112-161877090 (-)
129S1/SvImJ MGP_129S1SvImJ_G0016655
protein coding gene Chr1:167125430-167186705 (-)
A/J MGP_AJ_G0016636
protein coding gene Chr1:160318112-160380448 (-)
AKR/J MGP_AKRJ_G0016602
protein coding gene Chr1:165189756-165251483 (-)
BALB/cJ MGP_BALBcJ_G0016597
protein coding gene Chr1:160868294-160929013 (-)
C3H/HeJ MGP_C3HHeJ_G0016421
protein coding gene Chr1:165397014-165459293 (-)
C57BL/6NJ MGP_C57BL6NJ_G0017058
protein coding gene Chr1:172770545-172837636 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014767
protein coding gene Chr1:152408725-152471631 (-)
CAST/EiJ MGP_CASTEiJ_G0016001
protein coding gene Chr1:165034717-165098331 (-)
CBA/J MGP_CBAJ_G0016396
protein coding gene Chr1:178912665-178982537 (-)
DBA/2J MGP_DBA2J_G0016502
protein coding gene Chr1:159283989-159346726 (-)
FVB/NJ MGP_FVBNJ_G0016500
protein coding gene Chr1:157692718-157753478 (-)
LP/J MGP_LPJ_G0016573
protein coding gene Chr1:168230081-168301869 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0016525
protein coding gene Chr1:186431848-186521861 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0017094
protein coding gene Chr1:165035998-165099744 (-)
PWK/PhJ MGP_PWKPhJ_G0015787
protein coding gene Chr1:158460812-158522897 (-)
SPRET/EiJ MGP_SPRETEiJ_G0015574
protein coding gene Chr1:163917225-163977806 (-)
WSB/EiJ MGP_WSBEiJ_G0016063
protein coding gene Chr1:165202130-165264041 (-)



Homology
more
  • Human Ortholog
    SUCO, SUN domain containing ossification factor
  • Vertebrate Orthologs
    10
  • Human Ortholog
    SUCO, SUN domain containing ossification factor
    Orthology source: HomoloGene, HGNC
  • Synonyms
    C1orf9, CH1, OPT, SLP1
  • Links
    NCBI Gene ID: 51430
    neXtProt AC: NX_Q9UBS9
    UniProt: Q9UBS9

  • Chr Location
    1q24.3; chr1:172532349-172611833 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 32212
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: SUCO
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with Suco mouse models

Human Disease Mouse Models
      
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    46 phenotypes from 1 allele in 2 genetic backgrounds
    3 images
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a mutation in this gene display background strain-dependent neonatal and postnatal lethality, and impaired osteoblast differentiation resulting in impaired bone formation, brittle bones, and impaired fracture repair.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000040297 Ensembl Gene Model | MGI Sequence Detail 60569 C57BL/6J ±  kb
transcript ENSMUST00000048377 Ensembl | MGI Sequence Detail 6327 Not Applicable  
polypeptide ENSMUSP00000044815 Ensembl | MGI Sequence Detail 1254 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 87
    cDNA 87

    Microarray probesets 6
Other
Accession IDs
less
MGI:2138413
References
more
  • Summaries
    All 32
    Developmental Gene Expression 1
    Diseases 1
    Gene Ontology 3
    Phenotypes 9
  • Earliest
    J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
  • Latest
    J:265628 Gaudet P, et al., Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief Bioinform. 2011 Sep;12(5):449-62

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
10/08/2019
MGI 6.14
The Jackson Laboratory