Suco
Gene Detail

Symbol Name ID

Suco SUN domain containing ossification factor MGI:2138346

Synonyms

AI848100, Opt, osteopotentia

Feature Type

protein coding gene

Genetic Map

Chromosome 1

69.95 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr1:161816112-161876661 bp, - strand From NCBI annotation of GRCm38   60550 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:32212  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Suco

Human homologs

Human Homolog		SUCO, SUN domain containing ossification factor
NCBI Gene ID		51430
neXtProt AC		NX_Q9UBS9
Human Synonyms		C1orf9, CH1, OPT, SLP1
Human Chr (Location)		1q24; chr1:172502260-172580973 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(11) : Targeted(2) Gene trapped(9)
 

Mice homozygous for a mutation in this gene display background strain-dependent neonatal and postnatal lethality, and impaired osteoblast differentiation resulting in impaired bone formation, brittle bones, and impaired fracture repair.

 
Human Diseases Modeled Using Mouse Suco (1)    Alleles Annotated to Human Diseases(1)    Phenotype Images(3)

Gene Ontology (GO) classifications

All GO classifications: (10 annotations)

Process	multicellular organismal development, ossification, ...
Component	endoplasmic reticulum, integral to membrane, ...
Function	molecular_function

External Resources: FuncBase

Expression

Literature Summary: (1 records)
cDNA source data(86)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(86) cDNA(86)
Microarray probesets(6)

Other database links

Ensembl Gene Model	ENSMUSG00000040297 (Evidence)
Entrez Gene	226551 (Evidence)
UniGene	170002
DFCI	TC1581174, TC1607314, TC1607839
DoTS	DT.101254355, DT.101387627, DT.110923616, DT.97352134
Consensus CDS Project	CCDS48415.1
International Mouse Knockout Project Status	Suco

Sequences

Length	Strain/Species
genomic	226551	NCBI Gene Model | MGI Sequence Detail	60550	C57BL/6J
transcript	NM_172645	RefSeq | MGI Sequence Detail	6308	C57BL/6
polypeptide	Q8C341	UniProt | EBI | MGI Sequence Detail	1250	Not Applicable

All sequences(29) RefSeq(2) UniProt(2)

Polymorphisms

SNPs(253 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR008979	Galactose-binding domain-like
InterPro	IPR012919	Sad1/UNC-like, C-terminal
Protein Ontology	PR:000032354	SUN domain-containing ossification factor

Graphical View of Protein Domain Structure

References

(Earliest) J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
(Latest) J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
All references(32)

Other accession IDs

MGI:2138413