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Suco Gene Detail
Summary
  • Symbol
    Suco
  • Name
    SUN domain containing ossification factor
  • Synonyms
    AI848100, Opt, osteopotentia
  • Feature Type
    protein coding gene
  • IDs
    MGI:2138346
    NCBI Gene: 226551
Location & Maps
more
  • Sequence Map
    Chr1:161816114-161876682 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      60569 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 69.95 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    SUCO, SUN domain containing ossification factor
  • Vertebrate Orthologs
    10
  • Human Ortholog
    SUCO, SUN domain containing ossification factor
    Orthology source: HomoloGene, HGNC
  • Synonyms
    C1orf9, CH1, OPT, SLP1
  • Links
    NCBI Gene ID: 51430
    neXtProt AC: NX_Q9UBS9

  • Chr Location
    1q24; chr1:172532349-172611833 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 32212
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed
  • HCOP
    human homology predictions: SUCO
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with Suco mouse models

Human Disease Mouse Models
       Osteogenesis Imperfecta, Type V; OI5   OMIM: 610967 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    44 phenotypes from 1 allele in 2 genetic backgrounds
    3 images
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    13
  • Chemically induced (other)
    2
  • Gene trapped
    9
  • Targeted
    2
  • Genomic Mutations
    2 involving Suco
  • Incidental Mutations
    APF , CvDC
Mice homozygous for a mutation in this gene display background strain-dependent neonatal and postnatal lethality, and impaired osteoblast differentiation resulting in impaired bone formation, brittle bones, and impaired fracture repair.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000050995 VEGA Gene Model | MGI Sequence Detail 60569 C57BL/6J ±  kb
transcript OTTMUST00000129303 VEGA | MGI Sequence Detail 6327 Not Applicable  
polypeptide OTTMUSP00000069478 VEGA | MGI Sequence Detail 1254 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    368 from dbSNP Build 142
Protein
Information
less
  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000032354 SUN domain-containing ossification factor
  • InterPro Domains
    IPR008979 Galactose-binding domain-like
    IPR012919 SUN domain
Molecular
Reagents
less
  • All nucleic 86
    cDNA 86

    Microarray probesets 6
Other
Accession IDs
less
MGI:2138413
References
more
  • Summaries
    All 29
    Developmental Gene Expression 1
    Diseases 1
    Gene Ontology 2
    Phenotypes 9
  • Earliest
    J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
  • Latest
    J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
09/20/2016
MGI 6.05
The Jackson Laboratory