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Stk17b
Gene Detail
Symbol

Name
ID
Stk17b
serine/threonine kinase 17b (apoptosis-inducing)
MGI:2138162
Synonyms
3110009A03Rik, Drak2
Feature Type
protein coding gene
Genetic Map
Chromosome 1
26.99 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr1:53755506-53785224 bp, - strand
From VEGA annotation of GRCm38

  29719 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:31231  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

HCOP human homology predictions: STK17B
Protein SuperFamily: death-associated protein kinase 2
Gene Tree: Stk17b

Human
homologs
STK17B, serine/threonine kinase 17b
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 9262
neXtProt AC: NX_O94768

Human Synonyms: DRAK2

Human Chr (Location): 2q32.3; chr2:196133583-196176503 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(10) : Gene trapped(4) Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice display abnormal T cell numbers, increased T cell proliferation, abnormal cytokine physiology, and decreased susceptibility to experimental autoimmune encephalomyelitis.
 
Interactions
Stk17b interacts with 293 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (26 annotations)
Process apoptotic process, intracellular signal transduction, ...
Component actin cytoskeleton, membrane, ...
Function ATP binding, kinase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (54)    Tissues (38)    Images (16)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 52
RT-PCR 2
cDNA source data(125)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: ZFIN stk17b    NEW 
Molecular
reagents
All nucleic(126) cDNA(125) Primer pair(1)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000021434 (Evidence)
Ensembl Gene Model ENSMUSG00000026094 (Evidence)
Entrez Gene 98267 (Evidence)
UniGene 25559
DFCI TC1574407, TC1595525, TC1693163
DoTS DT.492845, DT.529916, DT.97345151
NIA Mouse Gene Index U021327
EC 2.7.11.1
Consensus CDS Project CCDS14955.1
International Mouse Phenotyping Consortium Status Stk17b
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021434 VEGA Gene Model | MGI Sequence Detail 29719 C57BL/6J ±  kb
transcript OTTMUST00000050819 VEGA | MGI Sequence Detail 3293 Not Applicable 
polypeptide OTTMUSP00000023815 VEGA | MGI Sequence Detail 372 Not Applicable 

For the selected sequences
All sequences(42) RefSeq(4) UniProt(2)
Polymorphisms
SNPs within 2kb(282 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR002290 Serine/threonine- / dual specificity protein kinase, catalytic domain
InterPro IPR008271 Serine/threonine-protein kinase, active site
Protein Ontology PR:000015744 serine/threonine-protein kinase 17B
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(45)
Other
accession IDs
MGI:1924228

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory