Stk17b Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Stk17b
serine/threonine kinase 17b (apoptosis-inducing)
MGI:2138162

20 phenotypes from 2 alleles in 3 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Stk17b^tm1Hed/Stk17b^tm1Hed B6.129X1-Stk17b^tm1Hed	abnormal cytokine secretion	J:94685
	decreased double-positive T cell number	J:94685
	decreased susceptibility to experimental autoimmune encephalomyelitis	J:94685
	increased CD4-positive, alpha-beta T cell number	J:94685
	increased interferon-gamma secretion	J:94685
	increased interleukin-2 secretion	J:94685
	increased memory T cell number	J:94685
	increased T cell proliferation	J:94685
	increased tumor necrosis factor secretion	J:94685
Stk17b^tm1Hed/Stk17b^tm1Hed involves: 129X1/SvJ * C57BL/6	increased T cell proliferation	J:94685
Tg(Lck-Stk17b)26.1Wals/? B6.Cg-Tg(Lck-Stk17b)26.1Wals	decreased CD4-positive, alpha-beta T cell number	J:149973
	decreased CD8-positive, alpha-beta T cell number	J:149973
	decreased single-positive T cell number	J:149973
	decreased thymocyte number	J:149973
	enlarged spleen	J:149973
	increased anti-nuclear antigen antibody level	J:149973
	increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number	J:149973
	increased double-positive T cell number	J:149973
	increased interleukin-2 secretion	J:149973
	increased spleen weight	J:149973
	increased susceptibility to experimental autoimmune encephalomyelitis	J:149973
	increased T cell proliferation	J:149973
	spleen hyperplasia	J:149973

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/30/2024 MGI 6.23