Twsg1
Gene Detail

Symbol Name ID

Twsg1 twisted gastrulation homolog 1 (Drosophila) MGI:2137520

Synonyms

1810013J15Rik, 9030422N06Rik, D17Ertd403e, Tsg

Feature Type

protein coding gene

Genetic Map

Chromosome 17

35.26 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr17:65923066-65951187 bp, - strand From Ensembl annotation of GRCm38   28122 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Mammalian homology

human; rat; cattle; chimpanzee; dog, domestic    (Mammalian Orthology)
Comparative Map (Mouse/Human Twsg1 ± 2 cM)

Gene Tree: Twsg1

Human ortholog

TWSG1 twisted gastrulation homolog 1 (Drosophila) NCBI Gene ID 57045
Human Synonyms: TSG
Human Chr18:9334765-9402418 bp, + strand Reference GRCh37.p2 Primary Assembly

Alleles and phenotypes

All alleles(16) : Targeted(6) Gene trapped(10)
 

Homozygous null mice appear healthy at birth, but more than half of the progeny fail to thrive and exhibit dwarfism with delayed ossification and immune system. These defects result in premature death.

 

Gene Ontology (GO) classifications

All GO classifications: (20 annotations)

Process	BMP signaling pathway, camera-type eye development, ...
Component	extracellular region, extracellular space
Function	protein binding

External Resources: FuncBase

Expression

Literature Summary: (15 records)
Data Summary: Results (75)    Tissues (63)    Images (21)
Theiler Stages: 12, 14, 17, 20, 22, 24, 26, 28

Assay Type	Results
RNA in situ	28
In situ reporter (knock in)	8
RT-PCR	39

cDNA source data(16)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(22) cDNA(18) Primer pair(3) Other(1)
Microarray probesets(7)

Other database links

Ensembl Gene Model	ENSMUSG00000024098 (Evidence)
Entrez Gene	65960 (Evidence)
DFCI	TC1576845, TC1604726, TC1626607
DoTS	DT.101383582, DT.532302, DT.97380615
NIA Mouse Gene Index	U038009
Consensus CDS Project	CCDS28942.1
International Mouse Knockout Project Status	Twsg1

Sequences

Length	Strain/Species
genomic	ENSMUSG00000024098	Ensembl Gene Model | MGI Sequence Detail	28122	C57BL/6J
transcript	ENSMUST00000024906	Ensembl | MGI Sequence Detail	4046	Not Applicable
polypeptide	ENSMUSP00000024906	Ensembl | MGI Sequence Detail	222	Not Applicable

All sequences(47) RefSeq(2) UniProt(1)

Polymorphisms

SNPs(14 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR006761	Twisted gastrulation (Tsg) protein
Protein Ontology	PR:000016849	twisted gastrulation protein 1

References

(Earliest) J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
(Latest) J:192165 Forsman CL, et al., BMP-binding protein twisted gastrulation is required in mammary gland epithelium for normal ductal elongation and myoepithelial compartmentalization. Dev Biol. 2013 Jan 1;373(1):95-106
All references(54)

Other accession IDs

MGI:1261766, MGI:1916293, MGI:1918789, MGI:2147085