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Twsg1
Gene Detail
 Symbol
Name
ID
Twsg1
twisted gastrulation homolog 1 (Drosophila)
MGI:2137520
Synonyms 1810013J15Rik, 9030422N06Rik, D17Ertd403e, Tsg
Feature Type protein coding gene
Genetic Map
Chromosome 17
35.26 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr17:65923066-65951187 bp, - strand
From Ensembl annotation of GRCm38

  28122 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:10774  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Twsg1

Human
homologs
Human Homolog TWSG1, twisted gastrulation BMP signaling modulator 1
NCBI Gene ID 57045
neXtProt AC  NX_Q9GZX9
Human Synonyms  TSG
Human Chr (Location)  18p11.3; chr18:9334767-9402420 (+)  GRCh38
Alleles
and
phenotypes
All alleles(16) : Gene trapped(10) Targeted(6)
Incidental mutations (data from APF )
 
Homozygous null mice appear healthy at birth, but more than half of the progeny fail to thrive and exhibit dwarfism with delayed ossification and immune system. These defects result in premature death.
 
Gene Ontology
(GO)
classifications
All GO classifications: (21 annotations)
Process BMP signaling pathway, camera-type eye development, ...
Component extracellular region, extracellular space, ...
Function protein binding
External Resources: FuncBase
Expression
Literature Summary: (17 records)
Data Summary: Results (75)    Tissues (63)    Images (21)
Theiler Stages: 12, 14, 17, 20, 22, 24, 26, 28
Assay TypeResults
RNA in situ 28
In situ reporter (knock in) 8
RT-PCR 39
cDNA source data(134)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(140) cDNA(136) Primer pair(3) Other(1)
Microarray probesets(7)
Other database
links
Ensembl Gene ModelENSMUSG00000024098 (Evidence)
Entrez Gene65960 (Evidence)
UniGene10153
DFCITC1576845, TC1604726, TC1626607
DoTSDT.101383582, DT.532302, DT.97380615
NIA Mouse Gene IndexU038009
Consensus CDS ProjectCCDS28942.1
International Mouse Knockout Project StatusTwsg1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000024098 Ensembl Gene Model | MGI Sequence Detail 28122 C57BL/6J ±  kb
transcript ENSMUST00000024906 Ensembl | MGI Sequence Detail 4046 Not Applicable 
polypeptide ENSMUSP00000024906 Ensembl | MGI Sequence Detail 222 Not Applicable 

For the selected sequences
All sequences(47) RefSeq(2) UniProt(1)
Polymorphisms SNPs within 2kb(26 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR006761 Twisted gastrulation (Tsg) protein
Protein Ontology PR:000016849 twisted gastrulation protein homolog 1
References (Earliest) J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
(Latest) J:204605 Minoux M, et al., Mouse Hoxa2 mutations provide a model for microtia and auricle duplication. Development. 2013 Nov;140(21):4386-97
All references(57)
Other
accession IDs
MGI:1261766, MGI:1916293, MGI:1918789, MGI:2147085

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory