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Twsg1 Gene Detail
Summary
  • Symbol
    Twsg1
  • Name
    twisted gastrulation BMP signaling modulator 1
  • Synonyms
    1810013J15Rik, 9030422N06Rik, D17Ertd403e, Tsg
  • Feature Type
    protein coding gene
  • IDs
    MGI:2137520
    NCBI Gene: 65960
  • Gene Overview
    MyGene.info: TWSG1
Location & Maps
more
  • Sequence Map
    Chr17:65923066-65951187 bp, - strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      28122 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 17, 35.26 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    TWSG1, twisted gastrulation BMP signaling modulator 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    TWSG1, twisted gastrulation BMP signaling modulator 1
    Orthology source: HomoloGene
  • Synonyms
    TSG
  • Links
    NCBI Gene ID: 57045
    neXtProt AC: NX_Q9GZX9

  • Chr Location
    18p11.3; chr18:9334767-9402420 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 10774
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: TWSG1
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    92 phenotypes from 6 alleles in 9 genetic backgrounds
    31 phenotypes from multigenic genotypes
    23 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    16
  • Gene trapped
    10
  • Targeted
    6
  • Incidental Mutations
    APF
Homozygous null mice appear healthy at birth, but more than half of the progeny fail to thrive and exhibit dwarfism with delayed ossification and immune system. These defects result in premature death.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000024098 Ensembl Gene Model | MGI Sequence Detail 28122 C57BL/6J ±  kb
transcript ENSMUST00000024906 Ensembl | MGI Sequence Detail 4046 Not Applicable  
polypeptide ENSMUSP00000024906 Ensembl | MGI Sequence Detail 222 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    26 from dbSNP Build 142
Protein
Information
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  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000016849 twisted gastrulation protein homolog 1
  • InterPro Domains
    IPR006761 Twisted gastrulation (Tsg) protein
Molecular
Reagents
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  • All nucleic 142
    cDNA 138
    Primer pair 3
    Other 1

    Microarray probesets 7
Other
Accession IDs
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MGI:1261766, MGI:1916293, MGI:1918789, MGI:2147085
References
more
  • Summaries
    All 56
    Developmental Gene Expression 18
    Gene Ontology 9
    Phenotypes 23
  • Earliest
    J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
  • Latest
    J:218248 Billington CJ Jr, et al., Impact of retinoic acid exposure on midfacial shape variation and manifestation of holoprosencephaly in Twsg1 mutant mice. Dis Model Mech. 2015 Feb;8(2):139-46

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/22/2016
MGI 6.04
The Jackson Laboratory