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Csmd1 Gene Detail
Summary
  • Symbol
    Csmd1
  • Name
    CUB and Sushi multiple domains 1
  • Feature Type
    protein coding gene
  • IDs
    MGI:2137383
    NCBI Gene: 94109
  • Gene Overview
    MyGene.info: CSMD1
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr8:15892537-17535586 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      1643050 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 8, 8.38 cM, cytoband A2
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    CSMD1, CUB and Sushi multiple domains 1
  • Vertebrate Orthologs
    8
  • Human Ortholog
    CSMD1, CUB and Sushi multiple domains 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    PPP1R24
  • Links
    NCBI Gene ID: 64478
    neXtProt AC: NX_Q96PZ7
    UniProt: Q96PZ7

  • Chr Location
    8p23.2; chr8:2935353-4995035 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with Csmd1 mouse models

Human Disease Mouse Models
      
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    11 phenotypes from 1 allele in 2 genetic backgrounds
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice exhibit normal pre-pulse inhibition, social interaction, sucrose preference and d-amphetamine sensitivity.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000033994 VEGA Gene Model | MGI Sequence Detail 1643050 C57BL/6J ±  kb
    transcript OTTMUST00000085800 VEGA | MGI Sequence Detail 14182 Not Applicable  
    polypeptide OTTMUSP00000046395 VEGA | MGI Sequence Detail 3564 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      14512 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 13
      cDNA 13

      Microarray probesets 4
    References
    more
    • Summaries
      All 29
      Developmental Gene Expression 1
      Diseases 2
      Gene Ontology 2
      Phenotypes 10
    • Earliest
      J:70242 Sun PC, et al., Transcript map of the 8p23 putative tumor suppressor region. Genomics. 2001 Jul;75(1-3):17-25
    • Latest
      J:238535 Drgonova J, et al., Altered CSMD1 Expression Alters Cocaine-Conditioned Place Preference: Mutual Support for a Complex Locus from Human and Mouse Models. PLoS One. 2015;10(7):e0120908

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    10/16/2018
    MGI 6.12
    The Jackson Laboratory