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P2rx5 Gene Detail
Summary
  • Symbol
    P2rx5
  • Name
    purinergic receptor P2X, ligand-gated ion channel, 5
  • Synonyms
    P2X5
  • Feature Type
    protein coding gene
  • IDs
    MGI:2137026
    NCBI Gene: 94045
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:73051247-73063511 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 11, 45.25 cM, cytoband B5
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    67 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2137026
protein coding gene Chr11:73046180-73063513 (+)
129S1/SvImJ MGP_129S1SvImJ_G0018653
protein coding gene Chr11:73839396-73851658 (+)
A/J MGP_AJ_G0018621
protein coding gene Chr11:71067048-71079201 (+)
AKR/J MGP_AKRJ_G0018590
protein coding gene Chr11:73238023-73250283 (+)
BALB/cJ MGP_BALBcJ_G0018593
protein coding gene Chr11:71368274-71380540 (+)
C3H/HeJ MGP_C3HHeJ_G0018406
protein coding gene Chr11:73190105-73202367 (+)
C57BL/6NJ MGP_C57BL6NJ_G0019044
protein coding gene Chr11:76088468-76100732 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0016687
protein coding gene Chr11:67872417-67885394 (+)
CAST/EiJ MGP_CASTEiJ_G0017961
protein coding gene Chr11:73573377-73585633 (+)
CBA/J MGP_CBAJ_G0018378
protein coding gene Chr11:79438907-79451154 (+)
DBA/2J MGP_DBA2J_G0018487
protein coding gene Chr11:70693837-70706033 (+)
FVB/NJ MGP_FVBNJ_G0018478
protein coding gene Chr11:70241283-70253547 (+)
LP/J MGP_LPJ_G0018558
protein coding gene Chr11:74354085-74368532 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0018501
protein coding gene Chr11:79951750-79964365 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0019086
protein coding gene Chr11:73421138-73433404 (+)
PWK/PhJ MGP_PWKPhJ_G0017734
protein coding gene Chr11:71335855-71348530 (+)
SPRET/EiJ MGP_SPRETEiJ_G0017524
protein coding gene Chr11:73137668-73149677 (+)
WSB/EiJ MGP_WSBEiJ_G0018015
protein coding gene Chr11:73168473-73181054 (+)



Homology
more
  • Human Ortholog
    P2RX5, purinergic receptor P2X 5
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    P2RX5, purinergic receptor P2X 5
  • Synonyms
    LRH-1, P2X5, P2X5R
  • Links
    NCBI Gene ID: 5026
    neXtProt AC: NX_Q93086
    UniProt: Q93086

  • Chr Location
    17p13.2; chr17:3672199-3696240 (-)  GRCh38

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    7 phenotypes from 2 alleles in 2 genetic backgrounds
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutant mice exhibit decreased peripheral blood CD8+ lymphocytes and elevated NK cells. Impaired learning/memory during trace aversive conditioning and increased exploratory behavior during open field testing is also seen.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000005950 Ensembl Gene Model | MGI Sequence Detail 12265 C57BL/6J ±  kb
transcript ENSMUST00000006104 Ensembl | MGI Sequence Detail 2395 Not Applicable  
polypeptide ENSMUSP00000006104 Ensembl | MGI Sequence Detail 455 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    7 Sequences
  • InterPro Domains
    IPR003048 P2X5 purinoceptor
    IPR001429 P2X purinoreceptor
    IPR027309 P2X purinoreceptor extracellular domain superfamily
Molecular
Reagents
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  • All nucleic 9
    Genomic 1
    cDNA 7
    Primer pair 1

    Microarray probesets 2
References
more
  • Summaries
    All 39
    Developmental Gene Expression 2
    Gene Ontology 4
    Phenotypes 16
  • Earliest
    J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
  • Latest
    J:326089 Ghnaimawi S, et al., The Effects of Maternal Intake of EPA and DHA Enriched Diet During Pregnancy and Lactation on Offspring's Muscle Development and Energy Homeostasis. Front Physiol. 2022;13:881624

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory