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Crb1 Gene Detail
Summary
  • Symbol
    Crb1
  • Name
    crumbs family member 1, photoreceptor morphogenesis associated
  • Synonyms
    7530426H14Rik, A930008G09Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2136343
    NCBI Gene: 170788
  • Gene Overview
    MyGene.info: CRB1
  • Alliance
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:139197056-139377100 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 60.87 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1116 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2136343
protein coding gene Chr1:139176123-139377299 (-)
129S1/SvImJ MGP_129S1SvImJ_G0016551
protein coding gene Chr1:143248885-143437917 (-)
A/J MGP_AJ_G0016534
protein coding gene Chr1:137681434-137863265 (-)
AKR/J MGP_AKRJ_G0016499
protein coding gene Chr1:141839153-142030584 (-)
BALB/cJ MGP_BALBcJ_G0016494
protein coding gene Chr1:138036583-138223577 (-)
C3H/HeJ MGP_C3HHeJ_G0016320
protein coding gene Chr1:141924857-142116663 (-)
C57BL/6NJ MGP_C57BL6NJ_G0016955
protein coding gene Chr1:148277492-148469260 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014666
protein coding gene Chr1:130744356-130922245 (-)
CAST/EiJ MGP_CASTEiJ_G0015900
protein coding gene Chr1:141092105-141285340 (-)
CBA/J MGP_CBAJ_G0016293
protein coding gene Chr1:153383294-153592946 (-)
DBA/2J MGP_DBA2J_G0016399
protein coding gene Chr1:136692672-136869883 (-)
FVB/NJ MGP_FVBNJ_G0016398
protein coding gene Chr1:135320190-135505175 (-)
LP/J MGP_LPJ_G0016470
protein coding gene Chr1:144345102-144531278 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0016423
protein coding gene Chr1:159041971-159237682 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0016991
protein coding gene Chr1:141631041-141827294 (-)
PWK/PhJ MGP_PWKPhJ_G0015686
protein coding gene Chr1:135760659-135942719 (-)
SPRET/EiJ MGP_SPRETEiJ_G0015473
protein coding gene Chr1:140581581-140767612 (-)
WSB/EiJ MGP_WSBEiJ_G0015963
protein coding gene Chr1:141636580-141826946 (-)



Homology
more
  • Human Ortholog
    CRB1, crumbs 1, cell polarity complex component
  • Vertebrate Orthologs
    10
  • Human Ortholog
    CRB1, crumbs 1, cell polarity complex component
    Orthology source: HomoloGene, HGNC
  • Synonyms
    LCA8, RP12
  • Links
    NCBI Gene ID: 23418
    neXtProt AC: NX_P82279
    UniProt: P82279

  • Chr Location
    1q31.3; chr1:197201462-197478455 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 8092
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: CRB1
  • Gene Tree
Human Diseases
more
  • Diseases
    2 with Crb1 mouse models; 2 with human CRB1 associations

Human Disease Mouse Models
      
IDs
View 3 models
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    3 with disease annotations
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    19 phenotypes from 4 alleles in 7 genetic backgrounds
    22 phenotypes from multigenic genotypes
    61 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygotes for a null allele show focal retinal lesions, loss of adherens junctions between photoreceptors and Muller glia cells, and light-accelerated retinal degeneration. Homozygotes for a spontaneous allele show background-sensitive retinal spotting, photoreceptor dysplasia and degeneration.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000063681 Ensembl Gene Model | MGI Sequence Detail 180045 C57BL/6J ±  kb
    transcript ENSMUST00000059825 Ensembl | MGI Sequence Detail 5901 Not Applicable  
    polypeptide ENSMUSP00000060769 Ensembl | MGI Sequence Detail 1405 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 37
      cDNA 33
      Primer pair 2
      Other 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2442131, MGI:2443401
    References
    more
    • Summaries
      All 100
      Developmental Gene Expression 13
      Diseases 3
      Gene Ontology 10
      Phenotypes 61
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:265859 Chang B, et al., Spontaneous posterior segment vascular disease phenotype of a mouse model, rnv3, is dependent on the Crb1 allele. Invest Ophthalmol Vis Sci. 2018;59:5127-5139

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory