About   Help   FAQ
Crb1
Gene Detail
Symbol

Name
ID
Crb1
crumbs family member 1, photoreceptor morphogenesis associated
MGI:2136343
Synonyms
7530426H14Rik, A930008G09Rik
Feature Type
protein coding gene
Genetic Map
Chromosome 1
60.87 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr1:139198254-139377076 bp, - strand
From Ensembl annotation of GRCm38

  178823 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:8092  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: CRB1
Gene Tree: Crb1

Human
homologs
CRB1, crumbs family member 1, photoreceptor morphogenesis associated
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 23418
neXtProt AC: NX_P82279

Human Synonyms: LCA8, RP12

Human Chr (Location): 1q31.3; chr1:197201462-197478455 (+)  GRCh38.p2

Disease Associations: (3) Diseases Associated with Human CRB1

Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Spontaneous(1) Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for a null allele show focal retinal lesions, loss of adherens junctions between photoreceptors and Muller glia cells, and light-accelerated retinal degeneration. Homozygotes for a spontaneous allele show background-sensitive retinal spotting, photoreceptor dysplasia and degeneration.
 
Human Diseases Modeled in Mice Using Crb1 (2)    Mutations Annotated to Human Diseases (3)   
Interactions
Crb1 interacts with 310 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (10 annotations)
Process eye photoreceptor cell development, membrane organization, ...
Component integral component of membrane, membrane, ...
Function calcium ion binding, protein binding
External Resources: FuncBase
Expression
Literature Summary: (9 records)
Data Summary: Results (141)    Tissues (122)    Images (35)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 6
RNA in situ 135
cDNA source data(32)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase crb1    NEW 
Molecular
reagents
All nucleic(34) cDNA(32) Primer pair(1) Other(1)
Microarray probesets(3)
Other database
links
Ensembl Gene Model ENSMUSG00000063681 (Evidence)
Entrez Gene 170788 (Evidence)
UniGene 95700
DFCI TC1584581, TC1614074, TC1587022, TC1594547
DoTS DT.91345779, DT.91326317, DT.102555912, DT.91336282, DT.101370696
NIA Mouse Gene Index U021836
Consensus CDS Project CCDS15336.1
International Mouse Phenotyping Consortium Status Crb1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000063681 Ensembl Gene Model | MGI Sequence Detail 178823 C57BL/6J ±  kb
transcript ENSMUST00000059825 Ensembl | MGI Sequence Detail 4702 Not Applicable 
polypeptide ENSMUSP00000060769 Ensembl | MGI Sequence Detail 1405 Not Applicable 

For the selected sequences
All sequences(46) RefSeq(14) UniProt(4)
Polymorphisms
SNPs within 2kb(1113 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR013320 Concanavalin A-like lectin/glucanase, subgroup
InterPro IPR001881 EGF-like calcium-binding
InterPro IPR018097 EGF-like calcium-binding, conserved site
InterPro IPR013032 EGF-like, conserved site
InterPro IPR000152 EGF-type aspartate/asparagine hydroxylation site
InterPro IPR000742 Epidermal growth factor-like domain
InterPro IPR009030 Insulin-like growth factor binding protein, N-terminal
InterPro IPR001791 Laminin G domain
Protein Ontology PR:000005848 protein crumbs homolog 1
References
(Earliest) J:73806 den Hollander AI, et al., Isolation of Crb1, a mouse homologue of Drosophila crumbs, and analysis of its expression pattern in eye and brain. Mech Dev. 2002 Jan;110(1-2):203-7
(Latest) J:220469 Grego-Bessa J, et al., Morphogenesis of the mouse neural plate depends on distinct roles of cofilin 1 in apical and basal epithelial domains. Development. 2015 Apr 1;142(7):1305-14
All references(65)
Disease annotation references (3)
Other
accession IDs
MGI:2442131, MGI:2443401

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
07/21/2015
MGI 5.22
The Jackson Laboratory