About   Help   FAQ
Crb1
Gene Detail
Symbol

Name
ID
Crb1
crumbs family member 1, photoreceptor morphogenesis associated
MGI:2136343
Synonyms
7530426H14Rik, A930008G09Rik
Feature Type
protein coding gene
Genetic Map
Chromosome 1
60.87 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr1:139197056-139377100 bp, - strand
From VEGA annotation of GRCm38

  180045 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:8092  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: CRB1
Gene Tree: Crb1

Human
homologs
CRB1, crumbs family member 1, photoreceptor morphogenesis associated
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 23418
neXtProt AC: NX_P82279

Human Synonyms: LCA8, RP12

Human Chr (Location): 1q31.3; chr1:197201462-197478455 (+)  GRCh38.p2

Disease Associations: (3) Diseases Associated with Human CRB1

Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Spontaneous(1) Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for a null allele show focal retinal lesions, loss of adherens junctions between photoreceptors and Muller glia cells, and light-accelerated retinal degeneration. Homozygotes for a spontaneous allele show background-sensitive retinal spotting, photoreceptor dysplasia and degeneration.
 
Human Diseases Modeled in Mice Using Crb1 (2)    Mutations Annotated to Human Diseases (3)   
Interactions
Crb1 interacts with 310 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (10 annotations)
Process eye photoreceptor cell development, membrane organization, ...
Component integral component of membrane, membrane, ...
Function calcium ion binding, protein binding
External Resources: FuncBase
Expression
Literature Summary: (9 records)
Data Summary: Results (141)    Tissues (122)    Images (35)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 6
RNA in situ 135
cDNA source data(32)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase crb1    NEW 
Molecular
reagents
All nucleic(34) cDNA(32) Primer pair(1) Other(1)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000033974 (Evidence)
Ensembl Gene Model ENSMUSG00000063681 (Evidence)
Entrez Gene 170788 (Evidence)
UniGene 95700
DFCI TC1584581, TC1587022, TC1594547, TC1614074
DoTS DT.101370696, DT.102555912, DT.91326317, DT.91336282, DT.91345779
NIA Mouse Gene Index U021836
Consensus CDS Project CCDS15336.1
International Mouse Phenotyping Consortium Status Crb1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000033974 VEGA Gene Model | MGI Sequence Detail 180045 C57BL/6J ±  kb
transcript OTTMUST00000085739 VEGA | MGI Sequence Detail 5901 Not Applicable 
polypeptide OTTMUSP00000046347 VEGA | MGI Sequence Detail 1405 Not Applicable 

For the selected sequences
All sequences(62) RefSeq(14) UniProt(7)
Polymorphisms
SNPs within 2kb(1120 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR013320 Concanavalin A-like lectin/glucanase domain
InterPro IPR018097 EGF-like calcium-binding, conserved site
InterPro IPR001881 EGF-like calcium-binding domain
InterPro IPR013032 EGF-like, conserved site
InterPro IPR000742 EGF-like domain
InterPro IPR000152 EGF-type aspartate/asparagine hydroxylation site
InterPro IPR009030 Insulin-like growth factor binding protein, N-terminal
InterPro IPR001791 Laminin G domain
Protein Ontology PR:000005848 protein crumbs homolog 1
References
(Earliest) J:73806 den Hollander AI, et al., Isolation of Crb1, a mouse homologue of Drosophila crumbs, and analysis of its expression pattern in eye and brain. Mech Dev. 2002 Jan;110(1-2):203-7
(Latest) J:220469 Grego-Bessa J, et al., Morphogenesis of the mouse neural plate depends on distinct roles of cofilin 1 in apical and basal epithelial domains. Development. 2015 Apr 1;142(7):1305-14
All references(66)
Disease annotation references (3)
Other
accession IDs
MGI:2442131, MGI:2443401

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
08/25/2015
MGI 6.0
The Jackson Laboratory