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Crb1
Gene Detail
 Symbol
Name
ID
Crb1
crumbs homolog 1 (Drosophila)
MGI:2136343
Synonyms 7530426H14Rik, A930008G09Rik
Feature Type protein coding gene
Genetic Map
Chromosome 1
60.87 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr1:139197056-139377100 bp, - strand
From VEGA annotation of GRCm38

  180045 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:8092  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Crb1

Human
homologs
Human Homolog CRB1, crumbs family member 1, photoreceptor morphogenesis associated
NCBI Gene ID 23418
neXtProt AC  NX_P82279
Human Synonyms  LCA8, RP12
Human Chr (Location)  1q31-q32.1; chr1:197201462-197478455 (+)  GRCh38
Disease Associations  (3) Diseases Associated with Human CRB1
Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Spontaneous(1) Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for a null allele show focal retinal lesions, loss of adherens junctions between photoreceptors and Muller glia cells, and light-accelerated retinal degeneration. Homozygotes for a spontaneous allele show background-sensitive retinal spotting, photoreceptor dysplasia and degeneration.
 
Human Diseases Modeled Using Mouse Crb1 (2)    Alleles Annotated to Human Diseases(3)   
Interactions
Crb1 interacts with 311 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (10 annotations)
Process eye photoreceptor cell development, membrane organization, ...
Component integral component of membrane, membrane, ...
Function calcium ion binding, protein binding
External Resources: FuncBase
Expression
Literature Summary: (7 records)
Data Summary: Results (141)    Tissues (122)    Images (35)
Theiler Stages: 11, 13, 17, 19, 20, 22, 24, 28
Assay TypeResults
Immunohistochemistry 6
RNA in situ 135
cDNA source data(32)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(34) cDNA(32) Primer pair(1) Other(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000033974 (Evidence)
Ensembl Gene ModelENSMUSG00000063681 (Evidence)
Entrez Gene170788 (Evidence)
UniGene95700
DFCITC1584581, TC1587022, TC1594547, TC1614074
DoTSDT.101370696, DT.102555912, DT.91326317, DT.91336282, DT.91345779
NIA Mouse Gene IndexU021836
Consensus CDS ProjectCCDS15336.1
International Mouse Knockout Project StatusCrb1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000033974 VEGA Gene Model | MGI Sequence Detail 180045 C57BL/6J ±  kb
transcript OTTMUST00000085739 VEGA | MGI Sequence Detail 5865 Not Applicable 
polypeptide OTTMUSP00000046347 VEGA | MGI Sequence Detail 1405 Not Applicable 

For the selected sequences
All sequences(79) RefSeq(18) UniProt(8)
Polymorphisms SNPs within 2kb(1120 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR008985 Concanavalin A-like lectin/glucanases superfamily
InterPro IPR013320 Concanavalin A-like lectin/glucanase, subgroup
InterPro IPR001881 EGF-like calcium-binding
InterPro IPR018097 EGF-like calcium-binding, conserved site
InterPro IPR013032 EGF-like, conserved site
InterPro IPR000152 EGF-type aspartate/asparagine hydroxylation site
InterPro IPR000742 Epidermal growth factor-like domain
InterPro IPR009030 Insulin-like growth factor binding protein, N-terminal
InterPro IPR001791 Laminin G domain
Protein Ontology PR:000005848 protein crumbs homolog 1
References (Earliest) J:73806 den Hollander AI, et al., Isolation of Crb1, a mouse homologue of Drosophila crumbs, and analysis of its expression pattern in eye and brain. Mech Dev. 2002 Jan;110(1-2):203-7
(Latest) J:210964 Wang Y, et al., Platelet-derived growth factor (PDGF)-C inhibits neuroretinal apoptosis in a murine model of focal retinal degeneration. Lab Invest. 2014 Jun;94(6):674-82
All references(60)
Disease annotation references (2)
Other
accession IDs
MGI:2442131, MGI:2443401

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/19/2014
MGI 5.19
The Jackson Laboratory