Crb1 Phenotype Annotations - Multigenic Genotypes

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Crb1
crumbs family member 1, photoreceptor morphogenesis associated
MGI:2136343

41 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Alpk1^em1Dlka/Alpk1⁺ Crb1^rd8/Crb1⁺ involves: C57BL/6J * C57BL/6N	normal vision/eye phenotype	J:344848
Alpk1^em1Dlka/Alpk1^em1Dlka Crb1^rd8/Crb1^rd8 involves: C57BL/6N	abnormal circulating chemokine level	J:344848
	normal growth/size/body region phenotype	J:344848
	normal immune system phenotype	J:344848
	increased circulating CXCL10 level	J:344848
Axin2^tm1Wbm/Axin2^tm1Wbm Crb1^rd8/? involves: 129P2/OlaHsd * C57BL/6	abnormal optic cup morphology	J:254591
	coloboma	J:254591
	small lens	J:254591
Crb1^rd8+em1Boc/Crb1^rd8+em1Boc Jak3^m1J/Jak3^m1J B6.Cg-Crb1^rd8+em1Boc Jak3^m1J/Boc	small spleen	J:265859
	small thymus	J:265859
	normal vision/eye phenotype	J:265859
Crb1^rd8/Crb1^rd8 Jak3^m1J/Jak3^m1J B6.Cg-Crb1^rd8 Jak3^m1J/BocJ	abnormal cone electrophysiology	J:265859
	abnormal electroretinogram waveform feature	J:265859
	abnormal eye electrophysiology	J:265859
	abnormal retina morphology	J:265859
	abnormal retina pigment epithelium morphology	J:265859
	abnormal retina pigmentation	J:265859
	abnormal retina vasculature morphology	J:265859
	abnormal rod electrophysiology	J:265859
	decreased spleen weight	J:265859
	retina neovascularization	J:265859
	retina spots	J:265859
	small spleen	J:265859
	small thymus	J:265859
Crb1^rd8/Crb1^rd8 Prkcq^tm1Litt/Prkcq^tm1Litt B6.129P2-Prkcq^tm1Litt	abnormal ocular fundus morphology	J:237977
	decreased eye pigmentation	J:237977
	retina degeneration	J:237977
	retina detachment	J:237977
Crb1^tm1Wij/Crb1⁺ Crb2^tm1.1Wij/Crb2^tm1.1Wij Tg(Chx10-EGFP/cre,-ALPP)2Clc/0 involves: 129P2/OlaHsd * C57BL/6 * C57BL/6JOlaHsd * SJL	abnormal electroretinogram waveform feature	J:207895
	abnormal eye physiology	J:207895
	abnormal retina development	J:207895
	abnormal retina ganglion layer morphology	J:207895
	abnormal retina layer morphology	J:207895
	abnormal retina morphology	J:207895
	abnormal retina outer limiting membrane morphology	J:207895
	abnormal retina photoreceptor layer morphology	J:207895
	decreased retina apoptosis	J:207895
	increased retina apoptosis	J:207895
Crb1^tm1Wij/Crb1^tm1Wij Crb2^tm1.1Wij/Crb2^tm1.1Wij Tg(Chx10-EGFP/cre,-ALPP)2Clc/0 involves: 129P2/OlaHsd * C57BL/6 * C57BL/6JOlaHsd * SJL	abnormal electroretinogram waveform feature	J:207895
	abnormal eye physiology	J:207895
	abnormal Muller cell morphology	J:207895
	abnormal retina bipolar cell morphology	J:207895
	abnormal retina layer morphology	J:207895
	abnormal retina morphology	J:207895
	abnormal retina outer limiting membrane morphology	J:207895
	abnormal retina photoreceptor layer morphology	J:207895
	abnormal retina progenitor cell morphology	J:207895
	decreased total retina thickness	J:207895
	disorganized retina layers	J:207895
	increased amacrine cell number	J:207895
	increased retina apoptosis	J:207895
	increased retina rod cell number	J:207895
	increased total retina thickness	J:207895
	retina degeneration	J:207895

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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