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Frs3 Gene Detail
Summary
  • Symbol
    Frs3
  • Name
    fibroblast growth factor receptor substrate 3
  • Synonyms
    4930417B13Rik, Frs2beta, MGC:25496, SNT2
  • Feature Type
    protein coding gene
  • IDs
    MGI:2135965
    NCBI Gene: 107971
  • Gene Overview
    MyGene.info: FRS3
Location & Maps
more
  • Sequence Map
    Chr17:47689030-47704286 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      15257 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 17, 23.88 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    FRS3, fibroblast growth factor receptor substrate 3
  • Vertebrate Orthologs
    10
  • Human Ortholog
    FRS3, fibroblast growth factor receptor substrate 3
    Orthology source: HomoloGene, HGNC
  • Synonyms
    FRS2B, FRS2beta, FRS2-beta, SNT2, SNT-2
  • Links
    NCBI Gene ID: 10817
    neXtProt AC: NX_O43559

  • Chr Location
    6p21.1; chr6:41770176-41779905 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 4845
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed
  • HCOP
    human homology predictions: FRS3
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    7 phenotype references
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000018351 VEGA Gene Model | MGI Sequence Detail 15257 C57BL/6J ±  kb
transcript OTTMUST00000044318 VEGA | MGI Sequence Detail 2144 Not Applicable  
polypeptide OTTMUSP00000019913 VEGA | MGI Sequence Detail 492 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    34 from dbSNP Build 142
Protein
Information
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  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000007671 fibroblast growth factor receptor substrate 3
  • InterPro Domains
    IPR002404 IRS-type PTB domain
    IPR011993 PH domain-like
Molecular
Reagents
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  • All nucleic 7
    cDNA 6
    Primer pair 1

    Microarray probesets 3
Other
Accession IDs
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MGI:2146863, MGI:2385322
References
more
  • Summaries
    All 35
    Developmental Gene Expression 6
    Gene Ontology 3
    Phenotypes 7
  • Earliest
    J:69784 McDougall K, et al., Developmental expression patterns of the signaling adapters FRS-2 and FRS-3 during early embryogenesis. Mech Dev. 2001 May;103(1-2):145-8
  • Latest
    J:226497 Brewer JR, et al., Fgfr1 regulates development through the combinatorial use of signaling proteins. Genes Dev. 2015 Sep 1;29(17):1863-74

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
09/27/2016
MGI 6.05
The Jackson Laboratory