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Sgpp1 Gene Detail
Summary
  • Symbol
    Sgpp1
  • Name
    sphingosine-1-phosphate phosphatase 1
  • Synonyms
    mSPP1, SPP, SPP1
  • Feature Type
    protein coding gene
  • IDs
    MGI:2135760
    NCBI Gene: 81535
  • Gene Overview
    MyGene.info: SGPP1
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:75714249-75735729 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 12, 32.95 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    130 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2135760
protein coding gene Chr12:75714248-75735729 (-)
129S1/SvImJ MGP_129S1SvImJ_G0019850
protein coding gene Chr12:75755128-75779667 (-)
A/J MGP_AJ_G0019808
protein coding gene Chr12:72913937-72936406 (-)
AKR/J MGP_AKRJ_G0019783
protein coding gene Chr12:75116177-75137425 (-)
BALB/cJ MGP_BALBcJ_G0019787
protein coding gene Chr12:73375091-73396826 (-)
C3H/HeJ MGP_C3HHeJ_G0019593
protein coding gene Chr12:75573743-75597644 (-)
C57BL/6NJ MGP_C57BL6NJ_G0020239
protein coding gene Chr12:78117206-78141965 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0017857
protein coding gene Chr12:70250494-70271863 (-)
CAST/EiJ MGP_CASTEiJ_G0019144
protein coding gene Chr12:70367695-70389880 (-)
CBA/J MGP_CBAJ_G0019563
protein coding gene Chr12:81113906-81138684 (-)
DBA/2J MGP_DBA2J_G0019679
protein coding gene Chr12:72771521-72792913 (-)
FVB/NJ MGP_FVBNJ_G0019666
protein coding gene Chr12:71602508-71623996 (-)
LP/J MGP_LPJ_G0019751
protein coding gene Chr12:75758719-75779951 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0019705
protein coding gene Chr12:84167488-84190779 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0020275
protein coding gene Chr12:74588381-74611378 (-)
PWK/PhJ MGP_PWKPhJ_G0018910
protein coding gene Chr12:67120315-67142278 (-)
SPRET/EiJ MGP_SPRETEiJ_G0018704
protein coding gene Chr12:69084234-69106336 (-)
WSB/EiJ MGP_WSBEiJ_G0019196
protein coding gene Chr12:75192541-75215994 (-)



Homology
more
  • Human Ortholog
    SGPP1, sphingosine-1-phosphate phosphatase 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    SGPP1, sphingosine-1-phosphate phosphatase 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    SPPase1
  • Links
    NCBI Gene ID: 81537
    neXtProt AC: NX_Q9BX95
    UniProt: Q9BX95

  • Chr Location
    14q23.2; chr14:63684216-63728095 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 101696
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: SGPP1
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    14 phenotypes from 1 allele in 1 genetic background
    3 images
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit abnormal keratinocyte differentiation and epidermal homeostasis with postnatal lethality.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000021054 Ensembl Gene Model | MGI Sequence Detail 21481 C57BL/6J ±  kb
    transcript ENSMUST00000021450 Ensembl | MGI Sequence Detail 3323 Not Applicable  
    polypeptide ENSMUSP00000021450 Ensembl | MGI Sequence Detail 430 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • Protein Ontology
      PR:000014801 sphingosine-1-phosphate phosphatase 1
    • EC
    • InterPro Domains
      IPR000326 Phosphatidic acid phosphatase type 2/haloperoxidase
      IPR036938 Phosphatidic acid phosphatase type 2/haloperoxidase superfamily
    Molecular
    Reagents
    less
    • All nucleic 14
      cDNA 13
      Primer pair 1

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGI:2144840
    References
    more
    • Summaries
      All 38
      Developmental Gene Expression 5
      Gene Ontology 5
      Phenotypes 6
    • Earliest
      J:68325 Mandala SM, et al., Molecular cloning and characterization of a lipid phosphohydrolase that degrades sphingosine-1- phosphate and induces cell death. Proc Natl Acad Sci U S A. 2000 Jul 5;97(14):7859-64
    • Latest
      J:255485 Li S, et al., Transcription Factor CTIP1/ BCL11A Regulates Epidermal Differentiation and Lipid Metabolism During Skin Development. Sci Rep. 2017 Oct 18;7(1):13427

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory