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Hes7
Gene Detail
 Symbol
Name
ID
Hes7
hairy and enhancer of split 7 (Drosophila)
MGI:2135679
Synonyms bHLHb37
Feature Type protein coding gene
Genetic Map
Chromosome 11
42.38 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr11:69120404-69124055 bp, + strand
From VEGA annotation of GRCm38

  3652 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:23779  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 cattle; 1 dog

Gene Tree: Hes7

Human
homologs
Human Homolog HES7, hes family bHLH transcription factor 7
NCBI Gene ID 84667
neXtProt AC  NX_Q9BYE0
Human Synonyms  bHLHb37, SCDO4
Human Chr (Location)  17p13.1; chr17:8120590-8124092 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human HES7
Alleles
and
phenotypes
All alleles(7) : Targeted(7)
 
Homozygotes for a targeted null mutation exhibit disrupted somite formation leading to skeletal defects including short trunk and tail, reduced numbers of ribs, and deformed and fused vertebrae, and neonatal death. Some heterozygotes have tail kinks.
 
Gene Ontology
(GO)
classifications
All GO classifications: (20 annotations)
Process multicellular organismal development, negative regulation of transcription, DNA-templated, ...
Component nucleus
Function DNA binding, protein dimerization activity, ...
External Resources: FuncBase
Expression
Literature Summary: (49 records)
Data Summary: Results (168)    Tissues (146)    Images (15)
Theiler Stages: 13, 15, 17, 19, 21, 22, 23, 28
Assay TypeResults
RNA in situ 168
cDNA source data(11)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(14) cDNA(11) Primer pair(2) Other(1)
Microarray probesets(2)
Other database
links
VEGA Gene ModelOTTMUSG00000005971 (Evidence)
Ensembl Gene ModelENSMUSG00000023781 (Evidence)
Entrez Gene84653 (Evidence)
UniGene98505
DFCITC1589382
DoTSDT.99847842
NIA Mouse Gene IndexU012811
Consensus CDS ProjectCCDS24883.1
International Mouse Knockout Project StatusHes7
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000005971 VEGA Gene Model | MGI Sequence Detail 3652 C57BL/6J ±  kb
transcript OTTMUST00000013339 VEGA | MGI Sequence Detail 1809 Not Applicable 
polypeptide OTTMUSP00000006176 VEGA | MGI Sequence Detail 225 Not Applicable 

For the selected sequences
All sequences(19) RefSeq(4) UniProt(1)
Polymorphisms SNPs within 2kb(42 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
InterPro IPR003650 Orange
Protein Ontology PR:000008521 transcription factor HES-7
References (Earliest) J:68229 Bessho Y, et al., Hes7: a bHLH-type repressor gene regulated by Notch and expressed in the presomitic mesoderm. Genes Cells. 2001 Feb;6(2):175-85
(Latest) J:202908 Hoyle NP, et al., Transcript processing and export kinetics are rate-limiting steps in expressing vertebrate segmentation clock genes. Proc Natl Acad Sci U S A. 2013 Nov 12;110(46):E4316-24
All references(76)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory