Hes7
Gene Detail

Symbol Name ID

Hes7 hairy and enhancer of split 7 (Drosophila) MGI:2135679

Synonyms

bHLHb37

Feature Type

protein coding gene

Genetic Map

Chromosome 11

42.38 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

Chr11:69120404-69124055 bp, + strand From VEGA annotation of GRCm38   3652 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:23779  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Gene Tree: Hes7

Human homologs

Human Homolog		HES7, hairy and enhancer of split 7 (Drosophila)
NCBI Gene ID		84667
neXtProt AC		NX_Q9BYE0
Human Synonyms		bHLHb37, SCDO4
Human Chr (Location)		17p13.1; chr17:8023908-8027410 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human HES7

Alleles and phenotypes

All alleles(7) : Targeted(7)
 

Homozygotes for a targeted null mutation exhibit disrupted somite formation leading to skeletal defects including short trunk and tail, reduced numbers of ribs, and deformed and fused vertebrae, and neonatal death. Some heterozygotes have tail kinks.

 

Gene Ontology (GO) classifications

All GO classifications: (18 annotations)

Process	multicellular organismal development, negative regulation of transcription, DNA-dependent, ...
Component	nucleus
Function	DNA binding, protein dimerization activity, ...

External Resources: FuncBase

Expression

Literature Summary: (45 records)
Data Summary: Results (160)    Tissues (145)    Images (7)
Theiler Stages: 15, 17, 19, 21, 22, 23, 28

Assay Type	Results
RNA in situ	160

cDNA source data(11)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(13) cDNA(11) Primer pair(2)
Microarray probesets(2)

Other database links

VEGA Gene Model	OTTMUSG00000005971 (Evidence)
Ensembl Gene Model	ENSMUSG00000023781 (Evidence)
Entrez Gene	84653 (Evidence)
UniGene	98505
DFCI	TC1589382
DoTS	DT.99847842
NIA Mouse Gene Index	U012811
Consensus CDS Project	CCDS24883.1
International Mouse Knockout Project Status	Hes7

Sequences

Length	Strain/Species
genomic	OTTMUSG00000005971	VEGA Gene Model | MGI Sequence Detail	3652	C57BL/6J
transcript	OTTMUST00000013339	VEGA | MGI Sequence Detail	1809	Not Applicable
polypeptide	OTTMUSP00000006176	VEGA | MGI Sequence Detail	225	Not Applicable

All sequences(17) RefSeq(2) UniProt(1)

Polymorphisms

SNPs(10 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR011598	Helix-loop-helix domain
InterPro	IPR003650	Orange
Protein Ontology	PR:000008521	transcription factor HES-7

References

(Earliest) J:68229 Bessho Y, et al., Hes7: a bHLH-type repressor gene regulated by Notch and expressed in the presomitic mesoderm. Genes Cells. 2001 Feb;6(2):175-85
(Latest) J:186213 Sparrow DB, et al., A mechanism for gene-environment interaction in the etiology of congenital scoliosis. Cell. 2012 Apr 13;149(2):295-306
All references(72)