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Hes7
Gene Detail
Symbol

Name
ID
Hes7
hairy and enhancer of split 7 (Drosophila)
MGI:2135679
Synonyms
bHLHb37
Feature Type
protein coding gene
Genetic Map
Chromosome 11
42.38 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr11:69120404-69124055 bp, + strand
From VEGA annotation of GRCm38

  3652 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:23779  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 cattle; 1 dog; 1 western clawed frog

HCOP human homology predictions: HES7
Gene Tree: Hes7

Human
homologs
HES7, hes family bHLH transcription factor 7
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 84667
neXtProt AC: NX_Q9BYE0

Human Synonyms: bHLHb37, SCDO4

Human Chr (Location): 17p13.1; chr17:8120590-8125739 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human HES7

Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Targeted(7)
 
Homozygotes for a targeted null mutation exhibit disrupted somite formation leading to skeletal defects including short trunk and tail, reduced numbers of ribs, and deformed and fused vertebrae, and neonatal death. Some heterozygotes have tail kinks.
 
Interactions
Hes7 interacts with 155 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (20 annotations)
Process multicellular organismal development, negative regulation of transcription, DNA-templated, ...
Component nucleus
Function DNA binding, protein dimerization activity, ...
External Resources: FuncBase
Expression
Literature Summary: (52 records)
Data Summary: Results (168)    Tissues (146)    Images (15)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 168
cDNA source data(11)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase hes7.1, LOC100496131 ; ZFIN her1    NEW 
Molecular
reagents
All nucleic(14) cDNA(11) Primer pair(2) Other(1)
Microarray probesets(2)
Other database
links
VEGA Gene Model OTTMUSG00000005971 (Evidence)
Ensembl Gene Model ENSMUSG00000023781 (Evidence)
Entrez Gene 84653 (Evidence)
UniGene 98505
DFCI TC1589382
DoTS DT.99847842
NIA Mouse Gene Index U012811
Consensus CDS Project CCDS24883.1
International Mouse Phenotyping Consortium Status Hes7
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000005971 VEGA Gene Model | MGI Sequence Detail 3652 C57BL/6J ±  kb
transcript OTTMUST00000013339 VEGA | MGI Sequence Detail 1809 Not Applicable 
polypeptide OTTMUSP00000006176 VEGA | MGI Sequence Detail 225 Not Applicable 

For the selected sequences
All sequences(19) RefSeq(4) UniProt(1)
Polymorphisms
SNPs within 2kb(42 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
InterPro IPR003650 Orange
Protein Ontology PR:000008521 transcription factor HES-7
References
(Earliest) J:68229 Bessho Y, et al., Hes7: a bHLH-type repressor gene regulated by Notch and expressed in the presomitic mesoderm. Genes Cells. 2001 Feb;6(2):175-85
(Latest) J:220460 Andre P, et al., Wnt5a and Wnt11 regulate mammalian anterior-posterior axis elongation. Development. 2015 Apr 15;142(8):1516-27
All references(78)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory