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Hes7 Gene Detail
Summary
  • Symbol
    Hes7
  • Name
    hairy and enhancer of split 7 (Drosophila)
  • Synonyms
    bHLHb37
  • Feature Type
    protein coding gene
  • IDs
    MGI:2135679
    NCBI Gene: 84653
Location & Maps
more
  • Sequence Map
    Chr11:69120404-69124055 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      3652 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 42.38 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    HES7, hes family bHLH transcription factor 7
  • Vertebrate Orthologs
    6
  • Human Ortholog
    HES7, hes family bHLH transcription factor 7
    Orthology source: HomoloGene, HGNC
  • Synonyms
    bHLHb37, SCDO4
  • Links
    NCBI Gene ID: 84667
    neXtProt AC: NX_Q9BYE0

  • Chr Location
    17p13.1; chr17:8120590-8125739 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human HES7 associations

Human Disease Mouse Models
       Spondylocostal Dysostosis 4, Autosomal Recessive; SCDO4   OMIM: 613686
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    29 phenotypes from 5 alleles in 3 genetic backgrounds
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    8
  • Chemically induced (other)
    1
  • Targeted
    7
  • Genomic Mutations
    1 involving Hes7
Homozygotes for a targeted null mutation exhibit disrupted somite formation leading to skeletal defects including short trunk and tail, reduced numbers of ribs, and deformed and fused vertebrae, and neonatal death. Some heterozygotes have tail kinks.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000005971 VEGA Gene Model | MGI Sequence Detail 3652 C57BL/6J ±  kb
transcript OTTMUST00000013339 VEGA | MGI Sequence Detail 1809 Not Applicable  
polypeptide OTTMUSP00000006176 VEGA | MGI Sequence Detail 225 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    56 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
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  • All nucleic 15
    cDNA 12
    Primer pair 2
    Other 1

    Microarray probesets 2
References
more
  • Summaries
    All 78
    Developmental Gene Expression 55
    Gene Ontology 11
    Phenotypes 15
  • Earliest
    J:68229 Bessho Y, et al., Hes7: a bHLH-type repressor gene regulated by Notch and expressed in the presomitic mesoderm. Genes Cells. 2001 Feb;6(2):175-85
  • Latest
    J:232560 Anderson MJ, et al., An FGF3-BMP Signaling Axis Regulates Caudal Neural Tube Closure, Neural Crest Specification and Anterior-Posterior Axis Extension. PLoS Genet. 2016 May;12(5):e1006018

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory