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Slc1a4 Gene Detail
Summary
  • Symbol
    Slc1a4
  • Name
    solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
  • Synonyms
    ASCT1
  • Feature Type
    protein coding gene
  • IDs
    MGI:2135601
    NCBI Gene: 55963
  • Gene Overview
    MyGene.info: SLC1A4
Location & Maps
more
  • Sequence Map
    Chr11:20302205-20332684 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      30480 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 12.97 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    SLC1A4, solute carrier family 1 member 4
  • Vertebrate Orthologs
    10
  • Human Ortholog
    SLC1A4, solute carrier family 1 member 4
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ASCT1, SATT, SPATCCM
  • Links
    NCBI Gene ID: 6509
    neXtProt AC: NX_P43007

  • Chr Location
    2p14; chr2:64988445-65023865 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human SLC1A4 associations

Human Disease Mouse Models
       Spastic Tetraplegia, Thin Corpus Callosum, and Progressive Microcephaly; SPATCCM   OMIM: 616657
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    6 phenotype references
  • All Mutations and Alleles
    4
  • Chemically induced (other)
    1
  • Gene trapped
    2
  • Targeted
    1
  • Genomic Mutations
    1 involving Slc1a4
  • Incidental Mutations
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000005224 VEGA Gene Model | MGI Sequence Detail 30480 C57BL/6J ±  kb
transcript OTTMUST00000011656 VEGA | MGI Sequence Detail 3872 Not Applicable  
polypeptide OTTMUSP00000005409 VEGA | MGI Sequence Detail 452 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    521 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 91
    cDNA 89
    Primer pair 1
    Other 1

    Microarray probesets 4
Other
Accession IDs
less
MGI:2144477
References
more
  • Summaries
    All 34
    Developmental Gene Expression 6
    Gene Ontology 6
    Phenotypes 6
  • Earliest
    J:69064 Marin M, et al., Sodium-dependent neutral amino acid transporter type 1 is an auxiliary receptor for baboon endogenous retrovirus. J Virol. 2000 Sep;74(17):8085-93
  • Latest
    J:205051 Miller JA, et al., Conserved molecular signatures of neurogenesis in the hippocampal subgranular zone of rodents and primates. Development. 2013 Nov;140(22):4633-44

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory