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Hadha
Gene Detail
Symbol

Name
ID
Hadha
hydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-Coenzyme A thiolase/enoyl-Coenzyme A hydratase (trifunctional protein), alpha subunit
MGI:2135593
Synonyms
Mtpa
Feature Type
protein coding gene
Genetic Map
Chromosome 5
15.95 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr5:30118304-30155162 bp, - strand
From VEGA annotation of GRCm38

  36859 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:152  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

HCOP human homology predictions: HADHA
Protein SuperFamily: enoyl-CoA hydratase/3-hydroxyacyl-CoA dehydrogenase
Gene Tree: Hadha

Human
homologs
HADHA, hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 3030
neXtProt AC: NX_P40939

Human Synonyms: ECHA, GBP, HADH, LCEH, LCHAD, MTPA, TP-ALPHA

Human Chr (Location): 2p23; chr2:26190635-26244726 (-)  GRCh38.p2

Disease Associations: (2) Diseases Associated with Human HADHA

Mutations,
alleles, and
phenotypes
All mutations/alleles(11) : Gene trapped(4) Radiation induced(4) Targeted(3)
Genomic Mutations involving Hadha (4)
Incidental mutations (data from APF , CvDC )
 
Mice homozygous for disruptions in this gene die within 36 hours with hypoglycemia and liver steatosis. Liver steatosis and insulin resistance develop in heterozygotes with age.
 
Mutations Annotated to Human Diseases (1)    Phenotype Images(4)
Interactions
Hadha interacts with 206 markers (Mir7-1, Mir7-2, Mir7b, ...)
Expression
Literature Summary: (3 records)
Data Summary: Results (106)    Tissues (96)    Images (21)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 94
Northern blot 6
Western blot 6
cDNA source data(212)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase hadha ; ZFIN hadhaa    NEW 
Molecular
reagents
All nucleic(213) cDNA(212) Primer pair(1)
Microarray probesets(2)
Other database
links
VEGA Gene Model OTTMUSG00000024740 (Evidence)
Ensembl Gene Model ENSMUSG00000025745 (Evidence)
Entrez Gene 97212 (Evidence)
UniGene 200497
DFCI TC1572143, TC1610580, TC1614392, TC1692994
NIA Mouse Gene Index U026044
EC 1.1.1.211, 4.2.1.17
Consensus CDS Project CCDS19155.1
International Mouse Phenotyping Consortium Status Hadha
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000024740 VEGA Gene Model | MGI Sequence Detail 36859 C57BL/6J ±  kb
transcript OTTMUST00000060908 VEGA | MGI Sequence Detail 4017 Not Applicable 
polypeptide OTTMUSP00000029769 VEGA | MGI Sequence Detail 763 Not Applicable 

For the selected sequences
All sequences(82) RefSeq(2) UniProt(4)
Polymorphisms
SNPs within 2kb(221 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR006180 3-hydroxyacyl-CoA dehydrogenase, conserved site
InterPro IPR006108 3-hydroxyacyl-CoA dehydrogenase, C-terminal
InterPro IPR006176 3-hydroxyacyl-CoA dehydrogenase, NAD binding
InterPro IPR008927 6-phosphogluconate dehydrogenase C-terminal domain-like
InterPro IPR013328 6-phosphogluconate dehydrogenase, domain 2
InterPro IPR029045 ClpP/crotonase-like domain
InterPro IPR001753 Crotonase superfamily
InterPro IPR018376 Enoyl-CoA hydratase/isomerase, conserved site
InterPro IPR012803 Fatty acid oxidation complex, alpha subunit, mitochondrial
InterPro IPR016040 NAD(P)-binding domain
Protein Ontology PR:000008433 trifunctional enzyme subunit alpha, mitochondrial
References
(Earliest) J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(36)
Other
accession IDs
MGI:2141283

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory