Hadha Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Hadha
hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha
MGI:2135593

39 phenotypes from 2 alleles in 2 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Hadha^em1Mbg/Hadha^em1Mbg C57BL/6J-Hadha^em1Mbg	abnormal blood homeostasis	J:370486
	abnormal heart echocardiography feature	J:370486
	abnormal retina pigment epithelium morphology	J:370486
	abnormal vision	J:370486
	cardiac hypertrophy	J:370486
	decreased b-wave amplitude	J:370486
	decreased c-wave amplitude	J:370486
	decreased cardiac muscle contractility	J:370486
	decreased cardiac output	J:370486
	decreased cardiac stroke volume	J:370486
	decreased circulating ketone body level	J:370486
	decreased fasting circulating glucose level	J:370486
	decreased fatty acid oxidation	J:370486
	dilated cardiomyopathy	J:370486
	impaired coordination	J:370486
	impaired exercise endurance	J:370486
	increased heart weight	J:370486
	increased respiratory quotient	J:370486
	preweaning lethality, incomplete penetrance	J:370486
Hadha^tm1Jib/Hadha⁺ involves: 129X1/SvJ * NIH Black Swiss	abnormal hepatocyte mitochondrial morphology	J:101304
	hepatic steatosis	J:101304
	increased circulating free fatty acids level	J:101304
	increased circulating insulin level	J:101304
	insulin resistance	J:101304
	macrovesicular hepatic steatosis	J:101304
	microvesicular hepatic steatosis	J:101304
Hadha^tm1Jib/Hadha^tm1Jib involves: 129X1/SvJ * NIH Black Swiss	abnormal blood homeostasis	J:69846
	abnormal diaphragm morphology	J:69846
	abnormal hepatocyte mitochondrial morphology	J:69846
	abnormal hepatocyte morphology	J:69846
	abnormal myocardium layer morphology	J:69846
	abnormal urine homeostasis	J:69846
	decreased circulating carnitine level	J:69846
	embryonic growth retardation	J:69846
	enlarged liver	J:69846
	hepatic steatosis	J:69846
	hypoglycemia	J:69846
	increased blood urea nitrogen level	J:69846
	increased circulating alanine transaminase level	J:69846
	increased circulating bilirubin level	J:69846
	increased circulating carnitine level	J:69846
	neonatal lethality, complete penetrance	J:69846

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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