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Vangl2
Gene Detail
Symbol

Name
ID
Vangl2
vang-like 2 (van gogh, Drosophila)
MGI:2135272
Synonyms
C530001F03Rik, loop-tail, Lpp1, Ltap, mKIAA1215, ska17, skam17Jus, strabismus
Feature Type
protein coding gene
Genetic Map
Chromosome 1
79.54 cM
Detailed Genetic Map ± 1 cM


Mapping data(31)
Sequence Map
Chr1:172000960-172028444 bp, - strand
From VEGA annotation of GRCm38

  27485 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:62161  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: Vang-like protein
Gene Tree: Vangl2

Human
homologs
Human Homolog VANGL2, VANGL planar cell polarity protein 2
NCBI Gene ID 57216
neXtProt AC  NX_Q9ULK5
Human Synonyms  LPP1, LTAP, STB1, STBM, STBM1
Human Chr (Location)  1q22-q23; chr1:160400574-160428678 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human VANGL2
Mutations,
alleles, and
phenotypes
All mutations/alleles(22) : Chemically induced (ENU)(3) Gene trapped(6) Spontaneous(1) Targeted(12)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous animals do not survive past birth. Developmental defects are seen in the nervous, cardiovascular, skeletal, vestibular, and respiratory systems. Kinked or looped tails are noted in heterozygotes with partial penetrance, along with a head wobble and some nervous system deficits.
 
Human Diseases Modeled Using Mouse Vangl2 (1)    Alleles Annotated to Human Diseases(1)    Phenotype Images(7)
Interactions
Vangl2 interacts with 338 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (89 annotations)
Process anterior/posterior pattern specification, apical protein localization, ...
Component apical plasma membrane, basolateral plasma membrane, ...
Function protein binding
External Resources: FuncBase
Expression
Literature Summary: (58 records)
Data Summary: Results (291)    Tissues (172)    Images (72)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 81
RNA in situ 170
Northern blot 18
Western blot 11
RT-PCR 11
cDNA source data(6)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(16) Genomic(2) cDNA(8) Primer pair(4) Other(2)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000021582 (Evidence)
Ensembl Gene ModelENSMUSG00000026556 (Evidence)
Entrez Gene93840 (Evidence)
DFCITC1581684, TC1604915, TC1604720, TC1615066, TC1650205
DoTSDT.40179442, DT.101364832, DT.97358585, DT.99851998
NIA Mouse Gene IndexU201395, U088869
Consensus CDS ProjectCCDS15505.1
International Mouse Knockout Project StatusVangl2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021582 VEGA Gene Model | MGI Sequence Detail 27485 C57BL/6J ±  kb
transcript OTTMUST00000051231 VEGA | MGI Sequence Detail 2349 Not Applicable 
polypeptide OTTMUSP00000024061 VEGA | MGI Sequence Detail 561 Not Applicable 

For the selected sequences
All sequences(67) RefSeq(12) UniProt(9)
Polymorphisms
SNPs within 2kb(200 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR009539 Strabismus
Protein Ontology PR:000017256 Vang-like protein 2
References
(Earliest) J:13059 Strong LC, et al., Hereditary loop-tail in the house mouse accompanied by imperforate vagina and craniorachischisis when homozygous. J Hered. 1949;40:329-334
(Latest) J:213956 Pryor SE, et al., Vangl-dependent planar cell polarity signalling is not required for neural crest migration in mammals. Development. 2014 Aug;141(16):3153-8
All references(188)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-11867, MGI:1924856, MGI:3038451, MGI:96818

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/18/2014
MGI 5.20
The Jackson Laboratory