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Vangl2
Gene Detail
Symbol

Name
ID
Vangl2
vang-like 2 (van gogh, Drosophila)
MGI:2135272
Synonyms
C530001F03Rik, loop-tail, Lpp1, Ltap, mKIAA1215, ska17, skam17Jus, strabismus
Feature Type
protein coding gene
Genetic Map
Chromosome 1
79.54 cM
Detailed Genetic Map ± 1 cM


Mapping data(31)
Sequence Map
Chr1:172000960-172028444 bp, - strand
From VEGA annotation of GRCm38

  27485 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:62161  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: VANGL2
Protein SuperFamily: Vang-like protein
Gene Tree: Vangl2

Human
homologs
VANGL2, VANGL planar cell polarity protein 2
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 57216
neXtProt AC: NX_Q9ULK5

Human Synonyms: LPP1, LTAP, STB1, STBM, STBM1

Human Chr (Location): 1q22-q23; chr1:160400574-160428678 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human VANGL2

Mutations,
alleles, and
phenotypes
All mutations/alleles(22) : Chemically induced (ENU)(3) Gene trapped(6) Spontaneous(1) Targeted(12)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous animals do not survive past birth. Developmental defects are seen in the nervous, cardiovascular, skeletal, vestibular, and respiratory systems. Kinked or looped tails are noted in heterozygotes with partial penetrance, along with a head wobble and some nervous system deficits.
 
Human Diseases Modeled in Mice Using Vangl2 (1)    Mutations Annotated to Human Diseases (1)    Phenotype Images(7)
Interactions
Vangl2 interacts with 338 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (93 annotations)
Process anterior/posterior pattern specification, apical protein localization, ...
Component apical plasma membrane, basolateral plasma membrane, ...
Function protein binding
External Resources: FuncBase
Expression
Literature Summary: (67 records)
Data Summary: Results (296)    Tissues (173)    Images (75)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 86
RNA in situ 170
Northern blot 18
Western blot 11
RT-PCR 11
cDNA source data(6)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase vangl2 ; ZFIN vangl2    NEW 
Molecular
reagents
All nucleic(16) Genomic(2) cDNA(8) Primer pair(4) Other(2)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000021582 (Evidence)
Ensembl Gene Model ENSMUSG00000026556 (Evidence)
Entrez Gene 93840 (Evidence)
DFCI TC1650205, TC1615066, TC1604915, TC1604720, TC1581684
DoTS DT.101364832, DT.99851998, DT.97358585, DT.40179442
NIA Mouse Gene Index U201395, U088869
Consensus CDS Project CCDS15505.1
International Mouse Phenotyping Consortium Status Vangl2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021582 VEGA Gene Model | MGI Sequence Detail 27485 C57BL/6J ±  kb
transcript OTTMUST00000051231 VEGA | MGI Sequence Detail 2349 Not Applicable 
polypeptide OTTMUSP00000024061 VEGA | MGI Sequence Detail 561 Not Applicable 

For the selected sequences
All sequences(63) RefSeq(12) UniProt(5)
Polymorphisms
SNPs within 2kb(200 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR009539 Strabismus
Protein Ontology PR:000017256 Vang-like protein 2
References
(Earliest) J:13059 Strong LC, et al., Hereditary loop-tail in the house mouse accompanied by imperforate vagina and craniorachischisis when homozygous. J Hered. 1949;40:329-334
(Latest) J:220460 Andre P, et al., Wnt5a and Wnt11 regulate mammalian anterior-posterior axis elongation. Development. 2015 Apr 15;142(8):1516-27
All references(198)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-11867, MGI:1924856, MGI:3038451, MGI:96818

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory