Symbol
Name
ID

Vangl2
VANGL planar cell polarity 2
MGI:2135272

Phenotype annotations related to hearing/vestibular/ear

*	Aspects of the system are reported to show a normal phenotype.
!	Indicates phenotype varies with strain background.
	Darker colors indicate more annotations

Mouse Phenotypes

hearing/vestibular/ear phenotype

abnormal otic pit morphology

abnormal ear development

abnormal otic vesicle development

abnormal inner ear morphology

abnormal cochlea morphology

abnormal cochlear hair cell morphology

increased cochlear hair cell number

increased cochlear outer hair cell number

abnormal orientation of inner hair cell stereociliary bundles

abnormal orientation of cochlear hair cell stereociliary bundles

abnormal orientation of outer hair cell stereociliary bundles

abnormal cochlear inner hair cell morphology

abnormal cochlear outer hair cell morphology

abnormal organ of Corti morphology

abnormal Deiters cell morphology

abnormal pillar cell morphology

short scala media

decreased cochlea coiling

abnormal vestibular hair cell morphology

abnormal semicircular canal morphology

dilated endolymphatic sac

inner ear hypoplasia

abnormal auditory brainstem response

increased or absent threshold for auditory brainstem response

abnormal distortion product otoacoustic emission

Availability

Mouse Genotype

Vangl2^Lp-m1Jus/Vangl2^Lp-m1Jus

Vangl2^Lp/Vangl2^Lp

Vangl2^tm1.2Mdea/Vangl2^tm1.2Mdea

Vangl2^tm1.2Yy/Vangl2^tm1.2Yy

Vangl2^tm2.2Mdea/Vangl2^tm2.2Mdea

Vangl2^Lp-2J/Vangl2⁺

Vangl2^Lp/Vangl2⁺

Vangl2^Lp/Vangl2^ska17

Vangl2^Lp/Vangl2^tm1.2Mdea

Tg(Pax2-cre)1Akg/0
Vangl2^tm1.2Mdea/Vangl2^tm2.1Mdea (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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