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Ube2n
Gene Detail
Symbol

Name
ID
Ube2n
ubiquitin-conjugating enzyme E2N
MGI:1934835
Synonyms
1500026J17Rik, UBC13
Feature Type
protein coding gene
Genetic Map
Chromosome 10
49.41 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr10:95515162-95545658 bp, + strand
From Ensembl annotation of GRCm38

  30497 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:128406  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

HCOP human homology predictions: UBE2N
Protein SuperFamily: ubiquitin-conjugating enzyme E2
Gene Tree: Ube2n

Human
homologs
UBE2N, ubiquitin-conjugating enzyme E2N
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 7334
neXtProt AC: NX_P61088

Human Synonyms: HEL-S-71, UBC13, UbcH13, UbcH-ben, UBCHBEN; UBC13

Human Chr (Location): 12q22; chr12:93408312-93443445 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(25) : Gene trapped(22) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous disruption of this gene causes early embryonic lethality. Mice heterozygous for a gene trap allele show increased resistance to LPS-induced lethality while cultured immune cells display blunted LPS-inducible cytokine secretion and impaired activation of TRAF-mediated signal transduction.
 
Interactions
Ube2n interacts with 347 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (42 annotations)
Process cellular response to DNA damage stimulus, DNA double-strand break processing, ...
Component cytoplasm, extracellular exosome, ...
Function ATP binding, ligase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (2)    Tissues (2)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 2
cDNA source data(13)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: Xenbase ube2n ; ZFIN ube2na, ube2nb    NEW 
Molecular
reagents
All nucleic(13) cDNA(13)
Microarray probesets(6)
Other database
links
Ensembl Gene Model ENSMUSG00000074781 (Evidence)
Entrez Gene 93765 (Evidence)
DFCI TC1574290, TC1606003, TC1629288
DoTS DT.101287518, DT.50314946, DT.534626
NIA Mouse Gene Index U043105, U062678, U096056, U139325, U273856, U302464
EC 6.3.2.19
Consensus CDS Project CCDS48677.1
International Mouse Phenotyping Consortium Status Ube2n
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000074781 Ensembl Gene Model | MGI Sequence Detail 30497 C57BL/6J ±  kb
transcript ENSMUST00000099329 Ensembl | MGI Sequence Detail 3851 Not Applicable 
polypeptide ENSMUSP00000096932 Ensembl | MGI Sequence Detail 152 Not Applicable 

For the selected sequences
All sequences(41) RefSeq(5) UniProt(2)
Polymorphisms
SNPs within 2kb(195 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR023313 Ubiquitin-conjugating enzyme, active site
InterPro IPR000608 Ubiquitin-conjugating enzyme, E2
InterPro IPR016135 Ubiquitin-conjugating enzyme/RWD-like
Protein Ontology PR:000003289 ubiquitin-conjugating enzyme E2 N
References
(Earliest) J:214866 JACKSON BR, et al., Recurrent carcinoma of the rectum, surgical treatment. Calif Med. 1959 Sep;91:149-50
(Latest) J:216379 Wu X, et al., Ubiquitin-conjugating enzyme Ubc13 controls breast cancer metastasis through a TAK1-p38 MAP kinase cascade. Proc Natl Acad Sci U S A. 2014 Sep 23;111(38):13870-5
All references(52)
Other
accession IDs
MGI:2143895, MGI:2144921

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory