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Ube2n Gene Detail
Summary
  • Symbol
    Ube2n
  • Name
    ubiquitin-conjugating enzyme E2N
  • Synonyms
    1500026J17Rik, UBC13
  • Feature Type
    protein coding gene
  • IDs
    MGI:1934835
    NCBI Gene: 93765
  • Gene Overview
    MyGene.info: UBE2N
Location & Maps
more
  • Sequence Map
    Chr10:95515162-95545658 bp, + strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      30497 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 10, 49.41 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    UBE2N, ubiquitin conjugating enzyme E2 N
  • Vertebrate Orthologs
    11
  • Human Ortholog
    UBE2N, ubiquitin conjugating enzyme E2 N
    Orthology source: HomoloGene, HGNC
  • Synonyms
    HEL-S-71, UBC13, UbcH13, UbcH-ben, UBCHBEN; UBC13
  • Links
    NCBI Gene ID: 7334
    neXtProt AC: NX_P61088

  • Chr Location
    12q22; chr12:93408312-93443445 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    15 phenotypes from 3 alleles in 2 genetic backgrounds
    22 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    27
  • Chemically induced (other)
    1
  • Gene trapped
    22
  • Targeted
    3
  • Transposon induced
    1
  • Genomic Mutations
    2 involving Ube2n
  • Incidental Mutations
Homozygous disruption of this gene causes early embryonic lethality. Mice heterozygous for a gene trap allele show increased resistance to LPS-induced lethality while cultured immune cells display blunted LPS-inducible cytokine secretion and impaired activation of TRAF-mediated signal transduction.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000074781 Ensembl Gene Model | MGI Sequence Detail 30497 C57BL/6J ±  kb
transcript ENSMUST00000099329 Ensembl | MGI Sequence Detail 3851 Not Applicable  
polypeptide ENSMUSP00000096932 Ensembl | MGI Sequence Detail 152 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    195 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 13
    cDNA 13

    Microarray probesets 6
Other
Accession IDs
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MGI:2143895, MGI:2144921
References
more
  • Summaries
    All 50
    Developmental Gene Expression 1
    Gene Ontology 11
    Phenotypes 22
  • Earliest
    J:214866 JACKSON BR, et al., Recurrent carcinoma of the rectum, surgical treatment. Calif Med. 1959 Sep;91:149-50
  • Latest
    J:219226 Yin P, et al., Aged monkey brains reveal the role of ubiquitin-conjugating enzyme UBE2N in the synaptosomal accumulation of mutant huntingtin. Hum Mol Genet. 2015 Mar 1;24(5):1350-62

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/22/2016
MGI 6.06
The Jackson Laboratory