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Ube2n Gene Detail
Summary
  • Symbol
    Ube2n
  • Name
    ubiquitin-conjugating enzyme E2N
  • Synonyms
    1500026J17Rik, UBC13
  • Feature Type
    protein coding gene
  • IDs
    MGI:1934835
    NCBI Gene: 93765
  • Gene Overview
    MyGene.info: UBE2N
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr10:95515162-95545658 bp, + strand
  • From NCBI annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      30497 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 10, 49.41 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    UBE2N, ubiquitin conjugating enzyme E2 N
  • Vertebrate Orthologs
    11
  • Human Ortholog
    UBE2N, ubiquitin conjugating enzyme E2 N
    Orthology source: HomoloGene, HGNC
  • Synonyms
    HEL-S-71, UBC13, UbcH13, UbcH-ben, UBCHBEN; UBC13
  • Links
    NCBI Gene ID: 7334
    neXtProt AC: NX_P61088
    UniProt: P61088

  • Chr Location
    12q22; chr12:93408312-93443808 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    15 phenotypes from 3 alleles in 2 genetic backgrounds
    25 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous disruption of this gene causes early embryonic lethality. Mice heterozygous for a gene trap allele show increased resistance to LPS-induced lethality while cultured immune cells display blunted LPS-inducible cytokine secretion and impaired activation of TRAF-mediated signal transduction.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 93765 NCBI Gene Model | MGI Sequence Detail 30497 C57BL/6J ±  kb
    transcript NM_080560 RefSeq | MGI Sequence Detail 3851 C57BL/6  
    polypeptide P61089 UniProt | EBI | MGI Sequence Detail 152 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      195 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 13
      cDNA 13

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:2143895, MGI:2144921
    References
    more
    • Summaries
      All 69
      Developmental Gene Expression 1
      Gene Ontology 13
      Phenotypes 25
    • Earliest
      J:214866 JACKSON BR, et al., Recurrent carcinoma of the rectum, surgical treatment. Calif Med. 1959 Sep;91:149-50
    • Latest
      J:260596 Zhang H, et al., Genetic rescue of lineage-balanced blood cell production reveals a crucial role for STAT3 antiinflammatory activity in hematopoiesis. Proc Natl Acad Sci U S A. 2018 Mar 6;115(10):E2311-E2319

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    05/15/2018
    MGI 6.12
    The Jackson Laboratory