Sequence Detail

ID/Version

P61089 Q9DAJ6 Q6ZWZ0 Q3TSL6 Q16781 (UniProt | EBI)

Last sequence update: 2004-04-26
Last annotation update: 2024-03-27

Sequence description from provider

RecName: Full=Ubiquitin-conjugating enzyme E2 N; EC=2.3.2.23 {ECO:0000269|PubMed:22424771, ECO:0000269|PubMed:28039360};AltName: Full=Bendless-like ubiquitin-conjugating enzyme;AltName: Full=E2 ubiquitin-conjugating enzyme N;AltName: Full=Ubc13;Al

Provider

SWISS-PROT

Sequence

Polypeptide 152 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Ube2n	ubiquitin-conjugating enzyme E2N	72	97	4	25

Sequence references in MGI

J:75985 Ashley C, et al., Roles of mouse UBC13 in DNA postreplication repair and Lys63-linked ubiquitination. Gene. 2002 Feb 20;285(1-2):183-91
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:104594 Zhang M, et al., Chaperoned ubiquitylation--crystal structures of the CHIP U box E3 ubiquitin ligase and a CHIP-Ubc13-Uev1a complex. Mol Cell. 2005 Nov 23;20(4):525-38
J:240887 Lentucci C, et al., Inhibition of Ubc13-mediated Ubiquitination by GPS2 Regulates Multiple Stages of B Cell Development. J Biol Chem. 2017 Feb 17;292(7):2754-2772
J:259114 Cardamone MD, et al., Mitochondrial Retrograde Signaling in Mammals Is Mediated by the Transcriptional Cofactor GPS2 via Direct Mitochondria-to-Nucleus Translocation. Mol Cell. 2018 Mar 1;69(5):757-772.e7
J:259118 Cardamone MD, et al., A protective strategy against hyperinflammatory responses requiring the nontranscriptional actions of GPS2. Mol Cell. 2012 Apr 13;46(1):91-104
J:260026 Cederquist CT, et al., Systemic insulin sensitivity is regulated by GPS2 inhibition of AKT ubiquitination and activation in adipose tissue. Mol Metab. 2017 Jan;6(1):125-137
J:281202 Shi Y, et al., Ube2D3 and Ube2N are essential for RIG-I-mediated MAVS aggregation in antiviral innate immunity. Nat Commun. 2017 May 4;8:15138
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89