Ick
Gene Detail

Symbol Name ID

Ick intestinal cell kinase MGI:1934157

Synonyms

2210420N10Rik

Feature Type

protein coding gene

Genetic Map

Chromosome 9

43.56 cM, cytoband E1
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr9:78109192-78172107 bp, + strand From VEGA annotation of GRCm38   62916 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:69218  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Gene Tree: Ick

Human homologs

Human Homolog		ICK, intestinal cell (MAK-like) kinase
NCBI Gene ID		22858
neXtProt AC		NX_Q9UPZ9
Human Synonyms		ECO, LCK2, MRK
Human Chr (Location)		6p12.1; chr6:52866098-52926600 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human ICK

Alleles and phenotypes

All alleles(33) : Targeted(1) Gene trapped(32)

Gene Ontology (GO) classifications

All GO classifications: (25 annotations)

Process	intracellular protein kinase cascade, multicellular organismal development, ...
Component	cytoplasm, intracellular membrane-bounded organelle
Function	ATP binding, cyclin-dependent protein serine/threonine kinase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (1 records)
Data Summary: Results (2)    Tissues (2)   
Theiler Stages: 22, 24

Assay Type	Results
RNA in situ	2

cDNA source data(75)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(76) cDNA(76)
Microarray probesets(8)

Other database links

VEGA Gene Model	OTTMUSG00000031751 (Evidence)
Ensembl Gene Model	ENSMUSG00000009828 (Evidence)
Entrez Gene	56542 (Evidence)
UniGene	288719
DFCI	TC1577319, TC1593048, TC1606536, TC1613668
DoTS	DT.101124592, DT.101180542, DT.101317623, DT.525036, DT.55119262, DT.55251026, DT.60100027
EC	2.7.11.22
Consensus CDS Project	CCDS40697.1
International Mouse Knockout Project Status	Ick

Sequences

Length	Strain/Species
genomic	OTTMUSG00000031751	VEGA Gene Model | MGI Sequence Detail	62916	C57BL/6J
transcript	OTTMUST00000078650	VEGA | MGI Sequence Detail	6560	Not Applicable
polypeptide	OTTMUSP00000041854	VEGA | MGI Sequence Detail	629	Not Applicable

All sequences(71) RefSeq(4) UniProt(7)

Polymorphisms

SNPs(134 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR017441	Protein kinase, ATP binding site
InterPro	IPR000719	Protein kinase, catalytic domain
InterPro	IPR011009	Protein kinase-like domain
InterPro	IPR002290	Serine/threonine- / dual-specificity protein kinase, catalytic domain
InterPro	IPR008271	Serine/threonine-protein kinase, active site
Protein Ontology	PR:000008883	serine/threonine-protein kinase ICK

References

(Earliest) J:21066 Mombaerts P, et al., An activated lck transgene promotes thymocyte development in RAG-1 mutant mice. Immunity. 1994 Jul;1(4):261-7
(Latest) J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
All references(38)

Other accession IDs

MGI:1917387, MGI:2143145