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Ick
Gene Detail
Symbol

Name
ID
Ick
intestinal cell kinase
MGI:1934157
Synonyms
2210420N10Rik
Feature Type
protein coding gene
Genetic Map
Chromosome 9
43.56 cM, cytoband E1
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr9:78109192-78172107 bp, + strand
From VEGA annotation of GRCm38

  62916 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:69218  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

HCOP human homology predictions: ICK
Gene Tree: Ick

Human
homologs
ICK, intestinal cell (MAK-like) kinase
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 22858
neXtProt AC: NX_Q9UPZ9

Human Synonyms: ECO, LCK2, MRK

Human Chr (Location): 6p12.1; chr6:53001299-53061833 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human ICK

Mutations,
alleles, and
phenotypes
All mutations/alleles(37) : Gene trapped(32) Radiation induced(1) Targeted(4)
Genomic Mutations involving Ick (1)
Incidental mutations (data from Mutagenetix , APF )
Interactions
Ick interacts with 430 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (32 annotations)
Process cell projection organization, cilium assembly, ...
Component cell projection, ciliary basal body, ...
Function ATP binding, cyclin-dependent protein serine/threonine kinase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (2)    Tissues (2)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 2
cDNA source data(75)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase ick    NEW 
Molecular
reagents
All nucleic(76) cDNA(76)
Microarray probesets(8)
Other database
links
VEGA Gene Model OTTMUSG00000031751 (Evidence)
Ensembl Gene Model ENSMUSG00000009828 (Evidence)
Entrez Gene 56542 (Evidence)
UniGene 288719
DFCI TC1613668, TC1606536, TC1577319, TC1593048
DoTS DT.101317623, DT.525036, DT.101180542, DT.101124592, DT.55119262, DT.55251026, DT.60100027
EC 2.7.11.22
Consensus CDS Project CCDS40697.1
International Mouse Phenotyping Consortium Status Ick
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000031751 VEGA Gene Model | MGI Sequence Detail 62916 C57BL/6J ±  kb
transcript OTTMUST00000078653 VEGA | MGI Sequence Detail 2540 Not Applicable 
polypeptide OTTMUSP00000041856 VEGA | MGI Sequence Detail 629 Not Applicable 

For the selected sequences
All sequences(75) RefSeq(8) UniProt(7)
Polymorphisms
SNPs within 2kb(211 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR002290 Serine/threonine- / dual specificity protein kinase, catalytic domain
InterPro IPR008271 Serine/threonine-protein kinase, active site
Protein Ontology PR:000008883 serine/threonine-protein kinase ICK
References
(Earliest) J:21066 Mombaerts P, et al., An activated lck transgene promotes thymocyte development in RAG-1 mutant mice. Immunity. 1994 Jul;1(4):261-7
(Latest) J:211665 Chaya T, et al., ICK is essential for cell type-specific ciliogenesis and the regulation of ciliary transport. EMBO J. 2014 Jun 2;33(11):1227-42
All references(41)
Other
accession IDs
MGI:1917387, MGI:2143145

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory