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Ick Gene Detail
Summary
  • Symbol
    Ick
  • Name
    intestinal cell kinase
  • Synonyms
    2210420N10Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1934157
    NCBI Gene: 56542
  • Gene Overview
    MyGene.info: ICK
Location & Maps
more
  • Sequence Map
    Chr9:78109192-78172107 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      62916 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 43.56 cM, cytoband E1
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    ICK, intestinal cell (MAK-like) kinase
  • Vertebrate Orthologs
    9
  • Human Ortholog
    ICK, intestinal cell (MAK-like) kinase
    Orthology source: HGNC, HomoloGene
  • Synonyms
    ECO, LCK2, MRK
  • Links
    NCBI Gene ID: 22858
    neXtProt AC: NX_Q9UPZ9

  • Chr Location
    6p12.1; chr6:53001299-53061833 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 69218
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog
  • HCOP
    human homology predictions: ICK
  • Gene Tree
    Ick
Human Diseases
more
  • Diseases
    1 with Ick mouse models; 1 with human ICK associations

Human Disease Mouse Models
       Endocrine-Cerebroosteodysplasia; ECO   OMIM: 612651 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    19 phenotypes from 1 allele in 1 genetic background
    3 images
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    38
  • Chemically induced (other)
    1
  • Gene trapped
    32
  • Radiation induced
    1
  • Targeted
    4
  • Genomic Mutations
    2 involving Ick
  • Incidental Mutations
Mice homozygous for a null allele exhibit abnormal primary cilium morphology and Shh signaling during limb digit patterning, peripheral edema, cleft palate, hydrocephalus, polydactyly, delayed skeletal development, and embryonic lethality at late stages of gestation.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000031751 VEGA Gene Model | MGI Sequence Detail 62916 C57BL/6J ±  kb
transcript OTTMUST00000078650 VEGA | MGI Sequence Detail 6560 Not Applicable  
polypeptide OTTMUSP00000041854 VEGA | MGI Sequence Detail 629 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    209 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 76
    cDNA 76

    Microarray probesets 8
Other
Accession IDs
less
MGI:1917387, MGI:2143145
References
more
  • Summaries
    All 40
    Developmental Gene Expression 3
    Diseases 1
    Gene Ontology 8
    Phenotypes 16
  • Earliest
    J:21066 Mombaerts P, et al., An activated lck transgene promotes thymocyte development in RAG-1 mutant mice. Immunity. 1994 Jul;1(4):261-7
  • Latest
    J:221534 Bolick DT, et al., Intestinal cell kinase is a novel participant in intestinal cell signaling responses to protein malnutrition. PLoS One. 2014;9(9):e106902

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/15/2016
MGI 6.04
The Jackson Laboratory