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Kremen1 Gene Detail
Summary
  • Symbol
    Kremen1
  • Name
    kringle containing transmembrane protein 1
  • Synonyms
    Krm1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1933988
    NCBI Gene: 84035
  • Gene Overview
    MyGene.info: KREMEN1
Location & Maps
more
  • Sequence Map
    Chr11:5191552-5261558 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      70007 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 3.36 cM, cytoband A1
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    KREMEN1, kringle containing transmembrane protein 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    KREMEN1, kringle containing transmembrane protein 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    KREMEN, KRM1
  • Links
    NCBI Gene ID: 83999
    neXtProt AC: NX_Q96MU8

  • Chr Location
    22q12.1; chr22:29073078-29168333 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    12 phenotypes from multigenic genotypes
    7 phenotype references
  • All Mutations and Alleles
    6
  • Gene trapped
    2
  • Targeted
    3
  • Transgenic
    1
  • Incidental Mutations
Mice homozygous for a null allele exhibit no abnormal phenotype.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000005082 VEGA Gene Model | MGI Sequence Detail 70007 C57BL/6J ±  kb
transcript OTTMUST00000011369 VEGA | MGI Sequence Detail 4856 Not Applicable  
polypeptide OTTMUSP00000005299 VEGA | MGI Sequence Detail 473 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    238 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 61
    cDNA 57
    Primer pair 2
    Other 2

    Microarray probesets 4
Other
Accession IDs
less
MGI:2144448
References
more
  • Summaries
    All 38
    Developmental Gene Expression 13
    Gene Ontology 4
    Phenotypes 7
  • Earliest
    J:68359 Nakamura T, et al., Molecular cloning and characterization of Kremen, a novel kringle-containing transmembrane protein. Biochim Biophys Acta. 2001 Mar 19;1518(1-2):63-72
  • Latest
    J:194074 Ahn Y, et al., Lrp4 and Wise interplay controls the formation and patterning of mammary and other skin appendage placodes by modulating Wnt signaling. Development. 2013 Feb 1;140(3):583-93

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/20/2016
MGI 6.05
The Jackson Laboratory