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Kremen1 Gene Detail
Summary
  • Symbol
    Kremen1
  • Name
    kringle containing transmembrane protein 1
  • Synonyms
    Krm1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1933988
    NCBI Gene: 84035
  • Gene Overview
    MyGene.info: KREMEN1
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:5191552-5261558 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 3.36 cM, cytoband A1
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    238 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1933988
protein coding gene Chr11:5191551-5261658 (-)
129S1/SvImJ MGP_129S1SvImJ_G0017999
protein coding gene Chr11:2218851-2293756 (-)
A/J MGP_AJ_G0017972
protein coding gene Chr11:2153008-2222667 (-)
AKR/J MGP_AKRJ_G0017936
protein coding gene Chr11:2275104-2351587 (-)
BALB/cJ MGP_BALBcJ_G0017940
protein coding gene Chr11:2134958-2205640 (-)
C3H/HeJ MGP_C3HHeJ_G0017753
protein coding gene Chr11:2156161-2227755 (-)
C57BL/6NJ MGP_C57BL6NJ_G0018392
protein coding gene Chr11:2289685-2362401 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0016050
protein coding gene Chr11:2044932-2114024 (-)
CAST/EiJ MGP_CASTEiJ_G0017315
protein coding gene Chr11:2114043-2186342 (-)
CBA/J MGP_CBAJ_G0017728
protein coding gene Chr11:2598262-2679068 (-)
DBA/2J MGP_DBA2J_G0017838
protein coding gene Chr11:2049738-2122477 (-)
FVB/NJ MGP_FVBNJ_G0017830
protein coding gene Chr11:2090385-2144339 (-)
LP/J MGP_LPJ_G0017909
protein coding gene Chr11:2303147-2378592 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0017856
protein coding gene Chr11:2218402-2290259 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0018432
protein coding gene Chr11:2255313-2326558 (-)
PWK/PhJ MGP_PWKPhJ_G0017095
protein coding gene Chr11:2070963-2144688 (-)
SPRET/EiJ MGP_SPRETEiJ_G0016892
protein coding gene Chr11:2243462-2315809 (-)
WSB/EiJ MGP_WSBEiJ_G0017369
protein coding gene Chr11:2123275-2193905 (-)



Homology
more
  • Human Ortholog
    KREMEN1, kringle containing transmembrane protein 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    KREMEN1, kringle containing transmembrane protein 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ECTD13, KREMEN, KRM1
  • Links
    NCBI Gene ID: 83999
    neXtProt AC: NX_Q96MU8
    UniProt: Q96MU8

  • Chr Location
    22q12.1; chr22:29073078-29168333 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    15 phenotypes from multigenic genotypes
    8 phenotype references
Mice homozygous for a null allele exhibit no abnormal phenotype.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000020393 Ensembl Gene Model | MGI Sequence Detail 70007 C57BL/6J ±  kb
transcript ENSMUST00000020662 Ensembl | MGI Sequence Detail 4856 Not Applicable  
polypeptide ENSMUSP00000020662 Ensembl | MGI Sequence Detail 473 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 63
    cDNA 58
    Primer pair 2
    Other 3

    Microarray probesets 4
Other
Accession IDs
less
MGI:2144448
References
more
  • Summaries
    All 45
    Developmental Gene Expression 18
    Gene Ontology 5
    Phenotypes 8
  • Earliest
    J:68359 Nakamura T, et al., Molecular cloning and characterization of Kremen, a novel kringle-containing transmembrane protein. Biochim Biophys Acta. 2001 Mar 19;1518(1-2):63-72
  • Latest
    J:242196 Xu M, et al., WNT10A mutation causes ectodermal dysplasia by impairing progenitor cell proliferation and KLF4-mediated differentiation. Nat Commun. 2017 Jun 07;8:15397

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory