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Mmp1a Gene Detail
Summary
  • Symbol
    Mmp1a
  • Name
    matrix metallopeptidase 1a (interstitial collagenase)
  • Synonyms
    Mcol-A
  • Feature Type
    protein coding gene
  • IDs
    MGI:1933846
    NCBI Gene: 83995
  • Gene Overview
    MyGene.info: MMP1
Location & Maps
more
  • Genetic Map
    Chromosome 9, 2.46 cM, cytoband A1-A2
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    MMP1, matrix metallopeptidase 1
  • Vertebrate Orthologs
    9
  • Human Ortholog
    MMP1, matrix metallopeptidase 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CLG, CLGN
  • Links
    NCBI Gene ID: 4312
    neXtProt AC: NX_P03956

  • Chr Location
    11q22.3; chr11:102789910-102798235 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    2 with human MMP1 associations

Human Disease Mouse Models
       Epidermolysis Bullosa Dystrophica, Autosomal Recessive; RDEB   OMIM: 226600
Pulmonary Disease, Chronic Obstructive; COPD   OMIM: 606963
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    9 phenotypes from 1 allele in 1 genetic background
    1 phenotype from multigenic genotypes
    2 images
    4 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit reduced inflammatory response following chemical induction of tumors and male mice exhibit fewer large induced tumors.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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  • All Sequences
  • RefSeq
  • UniProt
  • UniGene
Representative SequencesLengthStrain/SpeciesFlank
genomic 83995 NCBI Gene Model | MGI Sequence Detail 12729 C57BL/6J ±  kb
transcript NM_032006 RefSeq | MGI Sequence Detail 2025 C57BL/6  
polypeptide Q9EPL5 UniProt | EBI | MGI Sequence Detail 464 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    80 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 13
    Genomic 4
    cDNA 7
    Primer pair 2

    Microarray probesets 2
References
more
  • Summaries
    All 29
    Developmental Gene Expression 10
    Diseases 1
    Gene Ontology 5
    Phenotypes 4
  • Earliest
    J:68613 Balbin M, et al., Identification and enzymatic characterization of two diverging murine counterparts of human interstitial collagenase (MMP-1) expressed at sites of embryo implantation. J Biol Chem. 2001 Mar 30;276(13):10253-62
  • Latest
    J:220544 Takeda S, et al., Taspase1-dependent TFIIA cleavage coordinates head morphogenesis by limiting Cdkn2a locus transcription. J Clin Invest. 2015 Mar 2;125(3):1203-14

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
09/20/2016
MGI 6.05
The Jackson Laboratory