Mmp1a
Gene Detail

Symbol Name ID

Mmp1a matrix metallopeptidase 1a (interstitial collagenase) MGI:1933846

Synonyms

Mcol-A

Feature Type

protein coding gene

Genetic Map

Chromosome 9

2.46 cM, cytoband A1-A2
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr9:7464141-7476869 bp, + strand From NCBI annotation of GRCm38   12729 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:20544  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 2 cattle; 1 dog; 1 chicken

Protein SuperFamily: matrix metalloproteinase, stromelysin type
Gene Tree: Mmp1a

Human homologs

Human Homolog		MMP1, matrix metallopeptidase 1 (interstitial collagenase)
NCBI Gene ID		4312
neXtProt AC		NX_P03956
Human Synonyms		CLG, CLGN
Human Chr (Location)		11q22.3; chr11:102660641-102668966 (-)  GRCh37.p10
Disease Associations		(2) Diseases Associated with Human MMP1

Gene Ontology (GO) classifications

All GO classifications: (21 annotations)

Process	collagen catabolic process, metabolic process, ...
Component	cytoplasm, extracellular matrix, ...
Function	calcium ion binding, hydrolase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (7 records)
Data Summary: Results (31)    Tissues (21)    Images (5)
Theiler Stages: 13, 15, 17, 19, 20, 21, 23, 25, 26, 28

Assay Type	Results
RNA in situ	5
Northern blot	12
RT-PCR	14

cDNA source data(7)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(13) Genomic(4) cDNA(7) Primer pair(2)
Microarray probesets(2)

Other database links

Ensembl Gene Model	ENSMUSG00000043089 (Evidence)
Entrez Gene	83995 (Evidence)
UniGene	156952
DoTS	DT.99847125
EC	3.4.24.7
International Mouse Knockout Project Status	Mmp1a

Sequences

Length	Strain/Species
genomic	83995	NCBI Gene Model | MGI Sequence Detail	12729	C57BL/6J
transcript	NM_032006	RefSeq | MGI Sequence Detail	2025	C57BL/6
polypeptide	Q9EPL5	UniProt | EBI | MGI Sequence Detail	464	Not Applicable

All sequences(13) RefSeq(2) UniProt(2)

Polymorphisms

SNPs(54 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR000585	Hemopexin/matrixin
InterPro	IPR018486	Hemopexin/matrixin, conserved site
InterPro	IPR018487	Hemopexin/matrixin, repeat
InterPro	IPR024079	Metallopeptidase, catalytic domain
InterPro	IPR021158	Peptidase M10A, cysteine switch, zinc binding site
InterPro	IPR021190	Peptidase M10A, matrix metallopeptidase
InterPro	IPR016293	Peptidase M10A, matrix metallopeptidase, stromelysin type
InterPro	IPR001818	Peptidase M10, metallopeptidase
InterPro	IPR006026	Peptidase, metallopeptidase
InterPro	IPR002477	Peptidoglycan binding-like
Protein Ontology	PR:000010914	interstitial collagenase A

Graphical View of Protein Domain Structure

References

(Earliest) J:68613 Balbin M, et al., Identification and enzymatic characterization of two diverging murine counterparts of human interstitial collagenase (MMP-1) expressed at sites of embryo implantation. J Biol Chem. 2001 Mar 30;276(13):10253-62
(Latest) J:190686 Zheng Z, et al., Effects of matrix metalloproteinase-1 on the myogenic differentiation of bone marrow-derived mesenchymal stem cells in vitro. Biochem Biophys Res Commun. 2012 Nov 16;428(2):309-14
All references(25)