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Mmp1a
Gene Detail
 Symbol
Name
ID
Mmp1a
matrix metallopeptidase 1a (interstitial collagenase)
MGI:1933846
Synonyms Mcol-A
Feature Type protein coding gene
Genetic Map
Chromosome 9
2.46 cM, cytoband A1-A2
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr9:7464141-7476869 bp, + strand
From NCBI annotation of GRCm38

  12729 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20544  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 2 cattle; 1 dog; 1 chicken

Protein SuperFamily: matrix metalloproteinase, stromelysin type
Gene Tree: Mmp1a

Human
homologs
Human Homolog MMP1, matrix metallopeptidase 1 (interstitial collagenase)
NCBI Gene ID 4312
neXtProt AC  NX_P03956
Human Synonyms  CLG, CLGN
Human Chr (Location)  11q22.3; chr11:102789910-102798235 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human MMP1
Alleles
and
phenotypes
All alleles(1) : Targeted(1)
 
Mice homozygous for a knock-out allele exhibit reduced inflammatory response following chemical induction of tumors and male mice exhibit fewer large induced tumors.
 
Gene Ontology
(GO)
classifications
All GO classifications: (18 annotations)
Process collagen catabolic process, positive regulation of fibroblast migration, ...
Component cytoplasm, extracellular matrix, ...
Function calcium ion binding, hydrolase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (9 records)
Data Summary: Results (31)    Tissues (21)    Images (5)
Theiler Stages: 13, 15, 17, 19, 20, 21, 23, 25, 26, 28
Assay TypeResults
RNA in situ 5
Northern blot 12
RT-PCR 14
cDNA source data(7)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(13) Genomic(4) cDNA(7) Primer pair(2)
Microarray probesets(2)
Other database
links
Ensembl Gene ModelENSMUSG00000043089 (Evidence)
Entrez Gene83995 (Evidence)
UniGene156952
DoTSDT.99847125
EC3.4.24.7
International Mouse Knockout Project StatusMmp1a
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 83995 NCBI Gene Model | MGI Sequence Detail 12729 C57BL/6J ±  kb
transcript NM_032006 RefSeq | MGI Sequence Detail 2025 C57BL/6 
polypeptide Q9EPL5 UniProt | EBI | MGI Sequence Detail 464 Not Applicable 

For the selected sequences
All sequences(13) RefSeq(2) UniProt(2)
Polymorphisms SNPs within 2kb(89 from dbSNP Build 137)    SNPs within 2kb including multiple locations(109)
Protein-related
information
ResourceIDDescription
InterPro IPR018486 Hemopexin, conserved site
InterPro IPR000585 Hemopexin-like domain
InterPro IPR018487 Hemopexin-like repeats
InterPro IPR024079 Metallopeptidase, catalytic domain
InterPro IPR021190 Peptidase M10A
InterPro IPR021158 Peptidase M10A, cysteine switch, zinc binding site
InterPro IPR016293 Peptidase M10A, metazoans
InterPro IPR001818 Peptidase M10, metallopeptidase
InterPro IPR006026 Peptidase, metallopeptidase
InterPro IPR002477 Peptidoglycan binding-like
Protein Ontology PR:000010914 interstitial collagenase A
Graphical View of Protein Domain Structure
References (Earliest) J:68613 Balbin M, et al., Identification and enzymatic characterization of two diverging murine counterparts of human interstitial collagenase (MMP-1) expressed at sites of embryo implantation. J Biol Chem. 2001 Mar 30;276(13):10253-62
(Latest) J:201612 Takeda S, et al., HGF-MET signals via the MLL-ETS2 complex in hepatocellular carcinoma. J Clin Invest. 2013 Jul 1;123(7):3154-65
All references(28)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory