About   Help   FAQ
Jam3
Gene Detail
 Symbol
Name
ID
Jam3
junction adhesion molecule 3
MGI:1933825
Synonyms 1110002N23Rik, JAM-3, JAM-C, Jcam3
Feature Type protein coding gene
Genetic Map
Chromosome 9
12.27 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr9:27100668-27155418 bp, - strand
From VEGA annotation of GRCm38

  54751 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:11338  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

Gene Tree: Jam3

Human
homologs
Human Homolog JAM3, junctional adhesion molecule 3
NCBI Gene ID 83700
neXtProt AC  NX_Q9BX67
Human Synonyms  JAM-2, JAM-3, JAMC, JAM-C
Human Chr (Location)  11q25; chr11:134068925-134151757 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human JAM3
Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Gene trapped(1) Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Approximately 60% of mice homozygous for a targeted mutation exhibit postnatal lethality. Males are infertile and display small testes and arrested differentiation of round spermatids into spermatozoa, as shown by the absence of acrosomes, elongated nuclei, and morphological signs of polarization.
 
Human Diseases Modeled Using Mouse Jam3 (1)    Alleles Annotated to Human Diseases(1)    Phenotype Images(6)
Interactions
Jam3 interacts with 178 markers (Mir7-1, Mir9-1, Mir9-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (39 annotations)
Process adaptive immune response, angiogenesis, ...
Component cell-cell contact zone, cell-cell junction, ...
Function integrin binding, protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (205)    Tissues (24)    Images (24)
Theiler Stages: 23, 28
Assay TypeResults
RNA in situ 199
RT-PCR 6
cDNA source data(80)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(81) cDNA(80) Primer pair(1)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000036713 (Evidence)
Ensembl Gene ModelENSMUSG00000031990 (Evidence)
Entrez Gene83964 (Evidence)
UniGene28770
Consensus CDS ProjectCCDS22939.1
International Mouse Knockout Project StatusJam3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000036713 VEGA Gene Model | MGI Sequence Detail 54751 C57BL/6J ±  kb
transcript OTTMUST00000094061 VEGA | MGI Sequence Detail 1234 Not Applicable 
polypeptide OTTMUSP00000052252 VEGA | MGI Sequence Detail 210 Not Applicable 

For the selected sequences
All sequences(29) RefSeq(4) UniProt(2)
Polymorphisms SNPs within 2kb(132 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR013162 CD80-like, immunoglobulin C2-set
InterPro IPR013098 Immunoglobulin I-set
InterPro IPR007110 Immunoglobulin-like domain
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR003599 Immunoglobulin subtype
InterPro IPR003598 Immunoglobulin subtype 2
InterPro IPR013106 Immunoglobulin V-set
Protein Ontology PR:000009202 junctional adhesion molecule C
References (Earliest) J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
(Latest) J:201169 Leinster DA, et al., Endothelial cell junctional adhesion molecule C plays a key role in the development of tumors in a murine model of ovarian cancer. FASEB J. 2013 Oct;27(10):4244-4253
All references(60)
Disease annotation references (1)
Other
accession IDs
MGI:1914624, MGI:2143425

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
09/23/2014
MGI 5.19
The Jackson Laboratory