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Jam3
Gene Detail
Symbol

Name
ID
Jam3
junction adhesion molecule 3
MGI:1933825
Synonyms
1110002N23Rik, JAM-3, JAM-C, Jcam3
Feature Type
protein coding gene
Genetic Map
Chromosome 9
12.27 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr9:27100668-27155418 bp, - strand
From VEGA annotation of GRCm38

  54751 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:11338  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

HCOP human homology predictions: JAM3
Gene Tree: Jam3

Human
homologs
JAM3, junctional adhesion molecule 3
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 83700
neXtProt AC: NX_Q9BX67

Human Synonyms: JAM-2, JAM-3, JAMC, JAM-C

Human Chr (Location): 11q25; chr11:134068925-134151757 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human JAM3

Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Gene trapped(1) Targeted(6)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Approximately 60% of mice homozygous for a targeted mutation exhibit postnatal lethality. Males are infertile and display small testes and arrested differentiation of round spermatids into spermatozoa, as shown by the absence of acrosomes, elongated nuclei, and morphological signs of polarization.
 
Human Diseases Modeled in Mice Using Jam3 (1)    Mutations Annotated to Human Diseases (1)    Phenotype Images(6)
Interactions
Jam3 interacts with 177 markers (Mir7-1, Mir9-1, Mir9-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (40 annotations)
Process adaptive immune response, angiogenesis, ...
Component bicellular tight junction, cell-cell contact zone, ...
Function integrin binding, protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (205)    Tissues (24)    Images (24)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 199
RT-PCR 6
cDNA source data(80)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: GEISHA JAM3 ZFIN jam3a, jam3b    NEW 
Molecular
reagents
All nucleic(81) cDNA(80) Primer pair(1)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000036713 (Evidence)
Ensembl Gene Model ENSMUSG00000031990 (Evidence)
Entrez Gene 83964 (Evidence)
UniGene 28770
Consensus CDS Project CCDS22939.1
International Mouse Phenotyping Consortium Status Jam3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000036713 VEGA Gene Model | MGI Sequence Detail 54751 C57BL/6J ±  kb
transcript OTTMUST00000094061 VEGA | MGI Sequence Detail 1234 Not Applicable 
polypeptide OTTMUSP00000052252 VEGA | MGI Sequence Detail 210 Not Applicable 

For the selected sequences
All sequences(27) RefSeq(2) UniProt(2)
Polymorphisms
SNPs within 2kb(132 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR013162 CD80-like, immunoglobulin C2-set
InterPro IPR013098 Immunoglobulin I-set
InterPro IPR007110 Immunoglobulin-like domain
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR003599 Immunoglobulin subtype
InterPro IPR003598 Immunoglobulin subtype 2
InterPro IPR013106 Immunoglobulin V-set
Protein Ontology PR:000009202 junctional adhesion molecule C
References
(Earliest) J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
(Latest) J:215487 Thompson CL, et al., A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain. Neuron. 2014 Jul 16;83(2):309-23
All references(61)
Disease annotation references (1)
Other
accession IDs
MGI:1914624, MGI:2143425

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory