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Jam3 Gene Detail
Summary
  • Symbol
    Jam3
  • Name
    junction adhesion molecule 3
  • Synonyms
    1110002N23Rik, JAM-3, JAM-C, Jcam3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1933825
    NCBI Gene: 83964
  • Gene Overview
    MyGene.info: JAM3
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:27097384-27155421 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 12.27 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    135 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1933825
protein coding gene Chr9:27097384-27155421 (-)
129S1/SvImJ MGP_129S1SvImJ_G0034507
protein coding gene Chr9:24561042-24622967 (-)
A/J MGP_AJ_G0034485
protein coding gene Chr9:24018232-24077197 (-)
AKR/J MGP_AKRJ_G0034411
protein coding gene Chr9:24495040-24556018 (-)
BALB/cJ MGP_BALBcJ_G0034476
protein coding gene Chr9:23900424-23958497 (-)
C3H/HeJ MGP_C3HHeJ_G0034188
protein coding gene Chr9:24871456-24933856 (-)
C57BL/6NJ MGP_C57BL6NJ_G0034997
protein coding gene Chr9:25479983-25537868 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0031927
protein coding gene Chr9:22931698-22985750 (-)
CAST/EiJ MGP_CASTEiJ_G0033511
protein coding gene Chr9:24667878-24725395 (-)
CBA/J MGP_CBAJ_G0034161
protein coding gene Chr9:26379656-26441124 (-)
DBA/2J MGP_DBA2J_G0034319
protein coding gene Chr9:24049164-24106896 (-)
FVB/NJ MGP_FVBNJ_G0034262
protein coding gene Chr9:23476092-23533911 (-)
LP/J MGP_LPJ_G0034405
protein coding gene Chr9:24758152-24820468 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0034306
protein coding gene Chr9:28071103-28132891 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0035017
protein coding gene Chr9:24488134-24546780 (-)
PWK/PhJ MGP_PWKPhJ_G0033216
protein coding gene Chr9:23947349-24008841 (-)
SPRET/EiJ MGP_SPRETEiJ_G0033050
protein coding gene Chr9:24549706-24610885 (-)
WSB/EiJ MGP_WSBEiJ_G0033626
protein coding gene Chr9:24207584-24269790 (-)



Homology
more
  • Human Ortholog
    JAM3, junctional adhesion molecule 3
  • Vertebrate Orthologs
    10
  • Human Ortholog
    JAM3, junctional adhesion molecule 3
    Orthology source: HomoloGene, HGNC
  • Synonyms
    JAM-2, JAM-3, JAMC, JAM-C
  • Links
    NCBI Gene ID: 83700
    neXtProt AC: NX_Q9BX67
    UniProt: Q9BX67

  • Chr Location
    11q25; chr11:134068925-134151757 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    48 phenotypes from 5 alleles in 10 genetic backgrounds
    6 images
    22 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Approximately 60% of mice homozygous for a targeted mutation exhibit postnatal lethality. Males are infertile and display small testes and arrested differentiation of round spermatids into spermatozoa, as shown by the absence of acrosomes, elongated nuclei, and morphological signs of polarization.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 83964 NCBI Gene Model | MGI Sequence Detail 58038 C57BL/6J ±  kb
    transcript NM_023277 RefSeq | MGI Sequence Detail 1986 C57BL/6  
    polypeptide Q9D8B7 UniProt | EBI | MGI Sequence Detail 310 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 82
      cDNA 81
      Primer pair 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:1914624, MGI:2143425
    References
    more
    • Summaries
      All 71
      Developmental Gene Expression 8
      Gene Ontology 16
      Phenotypes 22
    • Earliest
      J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
    • Latest
      J:236599 Dickinson ME, et al., High-throughput discovery of novel developmental phenotypes. Nature. 2016 Sep 14;537(7621):508-514

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory