Jam3
Gene Detail

Symbol Name ID

Jam3 junction adhesion molecule 3 MGI:1933825

Synonyms

1110002N23Rik, JAM-3, JAM-C, Jcam3

Feature Type

protein coding gene

Genetic Map

Chromosome 9

12.27 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr9:27100668-27155418 bp, - strand From VEGA annotation of GRCm38   54751 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:11338  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 2 zebrafish

Gene Tree: Jam3

Human homologs

Human Homolog		JAM3, junctional adhesion molecule 3
NCBI Gene ID		83700
neXtProt AC		NX_Q9BX67
Human Synonyms		JAM-2, JAM-3, JAMC, JAM-C
Human Chr (Location)		11q25; chr11:133938820-134021652 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human JAM3

Alleles and phenotypes

All alleles(6) : Targeted(5) Gene trapped(1)
 

Approximately 60% of mice homozygous for a targeted mutation exhibit postnatal lethality. Males are infertile and display small testes and arrested differentiation of round spermatids into spermatozoa, as shown by the absence of acrosomes, elongated nuclei, and morphological signs of polarization.

 

Gene Ontology (GO) classifications

All GO classifications: (39 annotations)

Process	adaptive immune response, angiogenesis, ...
Component	cell-cell contact zone, cell-cell junction, ...
Function	integrin binding, protein binding, ...

External Resources: FuncBase

Expression

Literature Summary: (5 records)
Data Summary: Results (205)    Tissues (24)    Images (24)
Theiler Stages: 23, 28

Assay Type	Results
RNA in situ	199
RT-PCR	6

cDNA source data(81)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(82) cDNA(81) Primer pair(1)
Microarray probesets(5)

Other database links

VEGA Gene Model	OTTMUSG00000036713 (Evidence)
Ensembl Gene Model	ENSMUSG00000031990 (Evidence)
Entrez Gene	83964 (Evidence)
UniGene	28770
Consensus CDS Project	CCDS22939.1
International Mouse Knockout Project Status	Jam3

Sequences

Length	Strain/Species
genomic	OTTMUSG00000036713	VEGA Gene Model | MGI Sequence Detail	54751	C57BL/6J
transcript	OTTMUST00000094061	VEGA | MGI Sequence Detail	1234	Not Applicable
polypeptide	OTTMUSP00000052252	VEGA | MGI Sequence Detail	210	Not Applicable

All sequences(27) RefSeq(2) UniProt(2)

Polymorphisms

SNPs(117 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR013098	Immunoglobulin I-set
InterPro	IPR007110	Immunoglobulin-like domain
InterPro	IPR013783	Immunoglobulin-like fold
InterPro	IPR003599	Immunoglobulin subtype
InterPro	IPR003598	Immunoglobulin subtype 2
InterPro	IPR013106	Immunoglobulin V-set
Protein Ontology	PR:000009202	junctional adhesion molecule C

References

(Earliest) J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
(Latest) J:191990 Wyss L, et al., Junctional adhesion molecule (JAM)-C deficient C57BL/6 mice develop a severe hydrocephalus. PLoS One. 2012;7(9):e45619
All references(59)

Other accession IDs

MGI:1914624, MGI:2143425