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Jam2
Gene Detail
Symbol

Name
ID
Jam2
junction adhesion molecule 2
MGI:1933820
Synonyms
2410030G21Rik, 2410167M24Rik, JAM-2, Jcam2, VE-JAM
Feature Type
protein coding gene
Genetic Map
Chromosome 16
46.92 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr16:84774123-84825928 bp, + strand
From VEGA annotation of GRCm38

  51806 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:10929  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

Gene Tree: Jam2

Human
homologs
Human Homolog JAM2, junctional adhesion molecule 2
NCBI Gene ID 58494
neXtProt AC  NX_P57087
Human Synonyms  C21orf43, CD322, JAMB, JAM-B, PRO245, VEJAM, VE-JAM
Human Chr (Location)  21q21.2; chr21:25639282-25717562 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(343) : Gene trapped(337) Targeted(6)
Genomic Mutations involving Jam2 (2)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele are viable, fertile and overtly normal with no detectable spermatogenesis abnormalities or defects in embryonic, neural and hematopoietic stem cell properties.
 
Interactions
Jam2 interacts with 381 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (7 annotations)
Process negative regulation of cell adhesion
Component cell junction, integral component of membrane, ...
Function protein heterodimerization activity
External Resources: FuncBase
Expression
Literature Summary: (11 records)
Data Summary: Results (246)    Tissues (137)    Images (13)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 186
RT-PCR 60
cDNA source data(44)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(50) cDNA(45) Primer pair(5)
Microarray probesets(9)
Other database
links
VEGA Gene ModelOTTMUSG00000025168 (Evidence)
Ensembl Gene ModelENSMUSG00000053062 (Evidence)
Entrez Gene67374 (Evidence)
UniGene41758
DFCITC1666213, TC1643621, TC1594484, TC1581441
DoTSDT.87025888, DT.55261686, DT.40151007, DT.101313000
NIA Mouse Gene IndexU108508
Consensus CDS ProjectCCDS37381.1
International Mouse Knockout Project StatusJam2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000025168 VEGA Gene Model | MGI Sequence Detail 51806 C57BL/6J ±  kb
transcript OTTMUST00000061926 VEGA | MGI Sequence Detail 4370 Not Applicable 
polypeptide OTTMUSP00000030469 VEGA | MGI Sequence Detail 298 Not Applicable 

For the selected sequences
All sequences(48) RefSeq(6) UniProt(3)
Polymorphisms
SNPs within 2kb(506 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR013098 Immunoglobulin I-set
InterPro IPR007110 Immunoglobulin-like domain
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR003599 Immunoglobulin subtype
InterPro IPR003598 Immunoglobulin subtype 2
InterPro IPR013106 Immunoglobulin V-set
Protein Ontology PR:000001872 junctional adhesion molecule B
References
(Earliest) J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
(Latest) J:190703 Arcangeli ML, et al., The Junctional Adhesion Molecule-B regulates JAM-C-dependent melanoma cell metastasis. FEBS Lett. 2012 Nov 16;586(22):4046-51
All references(55)
Other
accession IDs
MGI:1914168, MGI:1924075, MGI:2146545

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory