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Pole3 Gene Detail
Summary
  • Symbol
    Pole3
  • Name
    polymerase (DNA directed), epsilon 3 (p17 subunit)
  • Synonyms
    1810034K18Rik, YBL1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1933378
    NCBI Gene: 59001
  • Gene Overview
    MyGene.info: POLE3
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:62442035-62443251 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 33.17 cM, cytoband C1
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    9 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1933378
protein coding gene Chr4:62440886-62443305 (-)
129S1/SvImJ MGP_129S1SvImJ_G0028357
protein coding gene Chr4:61513697-61516225 (-)
A/J MGP_AJ_G0028318
protein coding gene Chr4:59281413-59284375 (-)
AKR/J MGP_AKRJ_G0028267
protein coding gene Chr4:60927599-60930498 (-)
BALB/cJ MGP_BALBcJ_G0028338
protein coding gene Chr4:59458577-59462410 (-)
C3H/HeJ MGP_C3HHeJ_G0028056
protein coding gene Chr4:61428742-61431162 (-)
C57BL/6NJ MGP_C57BL6NJ_G0028778
protein coding gene Chr4:63624171-63626590 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0026084
protein coding gene Chr4:56570112-56572543 (-)
CAST/EiJ MGP_CASTEiJ_G0027492
protein coding gene Chr4:59369350-59371775 (-)
CBA/J MGP_CBAJ_G0028021
protein coding gene Chr4:65789179-65854636 (-)
DBA/2J MGP_DBA2J_G0028171
protein coding gene Chr4:59109472-59147497 (-)
FVB/NJ MGP_FVBNJ_G0028138
protein coding gene Chr4:58391157-58393270 (-)
LP/J MGP_LPJ_G0028270
protein coding gene Chr4:61785009-61787635 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0028165
protein coding gene Chr4:68951914-68955080 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0028814
protein coding gene Chr4:61029422-61032297 (-)
PWK/PhJ MGP_PWKPhJ_G0027219
protein coding gene Chr4:57621473-57623352 (-)
SPRET/EiJ MGP_SPRETEiJ_G0027048
protein coding gene Chr4:58476843-58477934 (-)
WSB/EiJ MGP_WSBEiJ_G0027572
protein coding gene Chr4:61008858-61011248 (-)



Homology
more
  • Human Ortholog
    POLE3, DNA polymerase epsilon 3, accessory subunit
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    POLE3, DNA polymerase epsilon 3, accessory subunit
  • Synonyms
    CHARAC17, CHRAC17, CHRAC2, p17, YBL1
  • Links
    NCBI Gene ID: 54107
    neXtProt AC: NX_Q9NRF9
    UniProt: Q9NRF9

  • Chr Location
    9q32; chr9:113407235-113410749 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    25 phenotypes from 6 alleles in 6 genetic backgrounds
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous knockout affects thymocyte development and bone ossification leading to late embryonic lethality. Mutations changing the charge of the peptide tail from negative to positive affect B cell and T cell maturation.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 59001 NCBI Gene Model | MGI Sequence Detail 1217 C57BL/6J ±  kb
    transcript NM_021498 RefSeq | MGI Sequence Detail 617 Not Specified  
    polypeptide Q9JKP7 UniProt | EBI | MGI Sequence Detail 145 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 11
      cDNA 10
      Primer pair 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:1919274
    References
    more
    • Summaries
      All 36
      Developmental Gene Expression 6
      Gene Ontology 5
      Phenotypes 7
    • Earliest
      J:65020 Bolognese F, et al., Cloning and characterization of the histone-fold proteins YBL1 and YCL1. Nucleic Acids Res. 2000 Oct 1;28(19):3830-8
    • Latest
      J:304329 Chen D, et al., VPS4B deficiency causes early embryonic lethality and induces signal transduction disorders of cell endocytosis. Genesis. 2021 Mar 7;:e23415

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    last database update
    07/20/2021
    MGI 6.17
    The Jackson Laboratory