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Elovl4
Gene Detail
Symbol

Name
ID
Elovl4
elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 4
MGI:1933331
Feature Type
protein coding gene
Genetic Map
Chromosome 9
45.60 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr9:83778692-83806277 bp, - strand
From VEGA annotation of GRCm38

  27586 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:41488  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 3 zebrafish

HCOP human homology predictions: ELOVL4
Gene Tree: Elovl4

Human
homologs
ELOVL4, ELOVL fatty acid elongase 4
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 6785
neXtProt AC: NX_Q9GZR5

Human Synonyms: ADMD, CT118, ISQMR, SCA34, STGD2, STGD3

Human Chr (Location): 6q14; chr6:79914812-79947598 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human ELOVL4

Mutations,
alleles, and
phenotypes
All mutations/alleles(15) : Gene trapped(1) Targeted(9) Transgenic(5)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null allele die before or around birth. Mice heterozygous for a null allele breed poorly and display mild retinal abnormalities.
 
Human Diseases Modeled in Mice Using Elovl4 (1)    Mutations Annotated to Human Diseases (5)   
Interactions
Elovl4 interacts with 257 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (6 records)
Data Summary: Results (27)    Tissues (7)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 27
cDNA source data(24)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase elovl4 ; ZFIN elovl4a, elovl4b    NEW 
Molecular
reagents
All nucleic(26) cDNA(26)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000044946 (Evidence)
Ensembl Gene Model ENSMUSG00000032262 (Evidence)
Entrez Gene 83603 (Evidence)
UniGene 83949
DFCI TC1676665, TC1577828
DoTS DT.40165246
NIA Mouse Gene Index U031148
EC 2.3.1.199
Consensus CDS Project CCDS23376.1
International Mouse Phenotyping Consortium Status Elovl4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000044946 VEGA Gene Model | MGI Sequence Detail 27586 C57BL/6J ±  kb
transcript OTTMUST00000118122 VEGA | MGI Sequence Detail 3001 Not Applicable 
polypeptide OTTMUSP00000065959 VEGA | MGI Sequence Detail 312 Not Applicable 

For the selected sequences
All sequences(32) RefSeq(2) UniProt(2)
Polymorphisms
SNPs within 2kb(332 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002076 GNS1/SUR4 membrane protein
Protein Ontology PR:000007039 elongation of very long chain fatty acids protein 4
References
(Earliest) J:66736 Zhang K, et al., A 5-bp deletion in ELOVL4 is associated with two related forms of autosomal dominant macular dystrophy. Nat Genet. 2001 Jan;27(1):89-93
(Latest) J:216600 Lau CG, et al., Morphology-based mammalian stem cell tests reveal potential developmental toxicity of donepezil. Mol Reprod Dev. 2014 Nov;81(11):994-1008
All references(45)
Disease annotation references (3)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory