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Lrba Gene Detail
Summary
  • Symbol
    Lrba
  • Name
    LPS-responsive beige-like anchor
  • Synonyms
    D3Ertd775e, Lba
  • Feature Type
    protein coding gene
  • IDs
    MGI:1933162
    NCBI Gene: 80877
  • Gene Overview
    MyGene.info: LRBA
Location & Maps
more
  • Sequence Map
    Chr3:86224680-86782692 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      558013 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    LRBA, LPS responsive beige-like anchor protein
  • Vertebrate Orthologs
    9
  • Human Ortholog
    LRBA, LPS responsive beige-like anchor protein
    Orthology source: HomoloGene
  • Synonyms
    BGL, CDC4L, CVID8, LAB300, LBA
  • Links
    NCBI Gene ID: 987
    neXtProt AC: NX_P50851

  • Chr Location
    4q31.3; chr4:150264659-151015727 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human LRBA associations

Human Disease Mouse Models
       Immunodeficiency, Common Variable, 8, with Autoimmunity; CVID8   OMIM: 614700
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    9 phenotype references
  • All Mutations and Alleles
    13
  • Chemically induced (other)
    1
  • Gene trapped
    10
  • Radiation induced
    1
  • Targeted
    1
  • Genomic Mutations
    2 involving Lrba
  • Incidental Mutations
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000051661 VEGA Gene Model | MGI Sequence Detail 558013 C57BL/6J ±  kb
transcript OTTMUST00000130331 VEGA | MGI Sequence Detail 9888 Not Applicable  
polypeptide OTTMUSP00000069869 VEGA | MGI Sequence Detail 2854 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    2417 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 62
    cDNA 60
    Primer pair 2

    Microarray probesets 6
Other
Accession IDs
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MGI:1289290, MGI:2140073
References
more
  • Summaries
    All 36
    Developmental Gene Expression 5
    Gene Ontology 3
    Phenotypes 9
  • Earliest
    J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
  • Latest
    J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory