Lrba
Gene Detail

Symbol Name ID

Lrba LPS-responsive beige-like anchor MGI:1933162

Synonyms

D3Ertd775e, Lba

Feature Type

protein coding gene

Genetic Map

Chromosome 3

37.83 cM, cytoband F1
Detailed Genetic Map ± 1 cM


Mapping data(5)

Sequence Map

Chr3:86224690-86782693 bp, + strand From Ensembl annotation of GRCm38   558004 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:36205  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Lrba

Human homologs

Human Homolog		LRBA, LPS-responsive vesicle trafficking, beach and anchor containing
NCBI Gene ID		987
neXtProt AC		NX_P50851
Human Synonyms		BGL, CDC4L, CVID8, LAB300, LBA
Human Chr (Location)		4q31.3; chr4:151185811-151936649 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human LRBA

Alleles and phenotypes

All alleles(11) : Targeted(1) Gene trapped(10)

Gene Ontology (GO) classifications

All GO classifications: (12 annotations)

Process	endosomal transport, protein localization, ...
Component	cytoplasmic membrane-bounded vesicle, endoplasmic reticulum, ...
Function	protein kinase A binding

External Resources: FuncBase

Expression

Literature Summary: (5 records)
Data Summary: Results (34)    Tissues (13)    Images (2)
Theiler Stages: 15, 17, 19, 23

Assay Type	Results
RNA in situ	34

cDNA source data(60)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(62) cDNA(60) Primer pair(2)
Microarray probesets(6)

Other database links

Ensembl Gene Model	ENSMUSG00000028080 (Evidence)
Entrez Gene	80877 (Evidence)
UniGene	439825
DFCI	TC1580201, TC1594789, TC1619477, TC1662487, TC1669010
DoTS	DT.111052023, DT.40175962, DT.487922, DT.532006, DT.94157660, DT.94199913, DT.97409719, DT.97409720
Consensus CDS Project	CCDS38470.1
International Mouse Knockout Project Status	Lrba

Sequences

Length	Strain/Species
genomic	ENSMUSG00000028080	Ensembl Gene Model | MGI Sequence Detail	558004	C57BL/6J
transcript	ENSMUST00000107635	Ensembl | MGI Sequence Detail	9882	Not Applicable
polypeptide	ENSMUSP00000103261	Ensembl | MGI Sequence Detail	2854	Not Applicable

All sequences(46) RefSeq(6) UniProt(5)

Polymorphisms

SNPs(2066 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR011989	Armadillo-like helical
InterPro	IPR016024	Armadillo-type fold
InterPro	IPR000409	BEACH domain
InterPro	IPR008985	Concanavalin A-like lectin/glucanases superfamily
InterPro	IPR013320	Concanavalin A-like lectin/glucanase, subgroup
InterPro	IPR010508	Domain of unknown function DUF1088
InterPro	IPR023362	PH-BEACH domain
InterPro	IPR001680	WD40 repeat
InterPro	IPR017986	WD40-repeat-containing domain
InterPro	IPR015943	WD40/YVTN repeat-like-containing domain
Protein Ontology	PR:000009910	lipopolysaccharide-responsive and beige-like anchor protein

References

(Earliest) J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
(Latest) J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
All references(36)

Other accession IDs

MGI:1289290, MGI:2140073