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Slc26a5 Gene Detail
Summary
  • Symbol
    Slc26a5
  • Name
    solute carrier family 26, member 5
  • Synonyms
    Pres, prestin
  • Feature Type
    protein coding gene
  • IDs
    MGI:1933154
    NCBI Gene: 80979
  • Gene Overview
    MyGene.info: SLC26A5
Location & Maps
more
  • Sequence Map
    Chr5:21810655-21865604 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      54950 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 9.97 cM, cytoband A3
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    SLC26A5, solute carrier family 26 member 5
  • Vertebrate Orthologs
    9
  • Human Ortholog
    SLC26A5, solute carrier family 26 member 5
    Orthology source: HomoloGene, HGNC
  • Synonyms
    DFNB61, PRES
  • Links
    NCBI Gene ID: 375611
    neXtProt AC: NX_P58743

  • Chr Location
    7q22.1; chr7:103352730-103446177 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human SLC26A5 associations

Human Disease Mouse Models
       Deafness, Autosomal Recessive 61; DFNB61   OMIM: 613865
Click on a disease name to see all genes associated with that disease.

  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    26 phenotypes from 6 alleles in 7 genetic backgrounds
    1 phenotype from multigenic genotypes
    30 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    14
  • Chemically induced (ENU)
    1
  • Chemically induced (other)
    2
  • Gene trapped
    1
  • Radiation induced
    1
  • Spontaneous
    1
  • Targeted
    8
  • Genomic Mutations
    4 involving Slc26a5
  • Incidental Mutations
Cochlear sensitivity is decreased in mutant due to a loss of outer hair cell electromotility.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000023668 VEGA Gene Model | MGI Sequence Detail 54950 C57BL/6J ±  kb
transcript OTTMUST00000057763 VEGA | MGI Sequence Detail 2962 Not Applicable  
polypeptide OTTMUSP00000027908 VEGA | MGI Sequence Detail 744 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    453 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 8
    Genomic 2
    cDNA 3
    Primer pair 3

    Microarray probesets 2
References
more
  • Summaries
    All 56
    Developmental Gene Expression 7
    Diseases 1
    Gene Ontology 8
    Phenotypes 30
  • Earliest
    J:24458 Bar I, et al., A YAC contig containing the reeler locus with preliminary characterization of candidate gene fragments. Genomics. 1995 Apr 10;26(3):543-9
  • Latest
    J:234901 Potter PK, et al., Novel gene function revealed by mouse mutagenesis screens for models of age-related disease. Nat Commun. 2016;7:12444

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/20/2016
MGI 6.05
The Jackson Laboratory