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Slc26a5
Gene Detail
Symbol

Name
ID
Slc26a5
solute carrier family 26, member 5
MGI:1933154
Synonyms
Pres, prestin
Feature Type
protein coding gene
Genetic Map
Chromosome 5
9.97 cM, cytoband A3
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr5:21810655-21865604 bp, - strand
From VEGA annotation of GRCm38

  54950 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:69472  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: sulfate transport protein
Gene Tree: Slc26a5

Human
homologs
Human Homolog SLC26A5, solute carrier family 26 (anion exchanger), member 5
NCBI Gene ID 375611
neXtProt AC  NX_P58743
Human Synonyms  DFNB61, PRES
Human Chr (Location)  7q22.1; chr7:103352730-103446177 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human SLC26A5
Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Gene trapped(1) Targeted(7)
Incidental mutations (data from Mutagenetix , APF )
 
Cochlear sensitivity is decreased in mutant due to a loss of outer hair cell electromotility.
 
Interactions
Slc26a5 interacts with 163 markers (Mir1b, Mir19b-2, Mir20a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (29 annotations)
Process anion transmembrane transport, chloride transmembrane transport, ...
Component basolateral plasma membrane, cytoplasm, ...
Function protein binding, protein homodimerization activity, ...
External Resources: FuncBase
Expression
Literature Summary: (7 records)
Data Summary: Results (34)    Tissues (29)    Images (2)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 23
Northern blot 2
RT-PCR 9
cDNA source data(3)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(8) Genomic(2) cDNA(3) Primer pair(3)
Microarray probesets(2)
Other database
links
VEGA Gene ModelOTTMUSG00000023668 (Evidence)
Ensembl Gene ModelENSMUSG00000029015 (Evidence)
Entrez Gene80979 (Evidence)
UniGene160370
DFCITC1595839
DoTSDT.110706390, DT.110706398, DT.110706397, DT.91326181
NIA Mouse Gene IndexU025969
Consensus CDS ProjectCCDS19109.1, CCDS71547.1
International Mouse Knockout Project StatusSlc26a5
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000023668 VEGA Gene Model | MGI Sequence Detail 54950 C57BL/6J ±  kb
transcript OTTMUST00000057763 VEGA | MGI Sequence Detail 2962 Not Applicable 
polypeptide OTTMUSP00000027908 VEGA | MGI Sequence Detail 744 Not Applicable 

For the selected sequences
All sequences(51) RefSeq(10) UniProt(9)
Polymorphisms
SNPs within 2kb(459 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002645 STAS domain
InterPro IPR001902 Sulphate anion transporter
InterPro IPR018045 Sulphate anion transporter, conserved site
InterPro IPR011547 Sulphate transporter
Protein Ontology PR:000015040 prestin
References
(Earliest) J:24458 Bar I, et al., A YAC contig containing the reeler locus with preliminary characterization of candidate gene fragments. Genomics. 1995 Apr 10;26(3):543-9
(Latest) J:208434 Cox BC, et al., Spontaneous hair cell regeneration in the neonatal mouse cochlea in vivo. Development. 2014 Feb;141(4):816-29
All references(56)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory