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Symbol
Name
ID 		Slc26a5
solute carrier family 26, member 5
MGI:1933154
Phenotype annotations related to hearing/vestibular/ear
*Aspects of the system are reported to show a normal phenotype.
Darker colors indicate more annotations
Human Phenotypes
Sensorineural hearing impairment
Disease(s) Associated with SLC26A5
autosomal recessive nonsyndromic deafness 61

Mouse Phenotypes
hearing/vestibular/ear phenotype
decreased cochlear outer hair cell number
cochlear inner hair cell degeneration
abnormal cochlear outer hair cell morphology
cochlear outer hair cell degeneration
short cochlear outer hair cells
cochlear hair cell degeneration
abnormal Claudius cell morphology
degeneration of organ of Corti supporting cells
organ of Corti degeneration
abnormal cochlear outer hair cell physiology
absent cochlear microphonics
decreased cochlear microphonics
abnormal cochlear outer hair cell electromotility
absent cochlear outer hair cell electromotility
decreased cochlear outer hair cell electromotility
increased or absent threshold for auditory brainstem response
decreased cochlear nerve compound action potential
increased cochlear nerve compound action potential
abnormal otoacoustic response
abnormal distortion product otoacoustic emission
absent distortion product otoacoustic emissions
impaired hearing
deafness
Availability Mouse Genotype
Slc26a5mpc234H/Slc26a5mpc234H
Slc26a5tm1Jnz/Slc26a5tm1Jnz
Slc26a5tm2Jnz/Slc26a5tm2Jnz
Slc26a5tm3Jnz/Slc26a5tm3Jnz
Slc26a5tm4.1(cre/ERT2)Jnz/Slc26a5tm4.1(cre/ERT2)Jnz
Slc26a5tm1Jnz/Slc26a5+
Slc26a5tm4(cre/ERT2)Jnz/Slc26a5+ *
Slc26a5tm4.1(cre/ERT2)Jnz/Slc26a5+ *
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory