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Ucn3 Gene Detail
Summary
  • Symbol
    Ucn3
  • Name
    urocortin 3
  • Synonyms
    Urocortin III
  • Feature Type
    protein coding gene
  • IDs
    MGI:1932970
    NCBI Gene: 83428
  • Gene Overview
    MyGene.info: UCN3
  • Alliance
Location &
Maps
more
  • Sequence Map
    Chr13:3940688-3945349 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 13, 2.20 cM, cytoband A1
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    56 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1932970
protein coding gene Chr13:3940688-3945349 (-)
129S1/SvImJ MGP_129S1SvImJ_G0020201
protein coding gene Chr13:430925-435584 (-)
A/J MGP_AJ_G0020157
protein coding gene Chr13:531773-536432 (-)
AKR/J MGP_AKRJ_G0020132
protein coding gene Chr13:539864-544521 (-)
BALB/cJ MGP_BALBcJ_G0020140
protein coding gene Chr13:539438-544095 (-)
C3H/HeJ MGP_C3HHeJ_G0019944
protein coding gene Chr13:606789-611436 (-)
C57BL/6NJ MGP_C57BL6NJ_G0020587
protein coding gene Chr13:507978-512641 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0018199
protein coding gene Chr13:447585-452325 (-)
CAST/EiJ MGP_CASTEiJ_G0019484
protein coding gene Chr13:439138-443782 (-)
CBA/J MGP_CBAJ_G0019911
protein coding gene Chr13:502460-507095 (-)
DBA/2J MGP_DBA2J_G0020028
protein coding gene Chr13:445058-449719 (-)
FVB/NJ MGP_FVBNJ_G0020013
protein coding gene Chr13:432438-437077 (-)
LP/J MGP_LPJ_G0020102
protein coding gene Chr13:505703-510373 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0020049
protein coding gene Chr13:548212-552869 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0020615
protein coding gene Chr13:520416-525094 (-)
PWK/PhJ MGP_PWKPhJ_G0019246
protein coding gene Chr13:512741-517464 (-)
SPRET/EiJ MGP_SPRETEiJ_G0019051
protein coding gene Chr13:537282-541927 (-)
WSB/EiJ MGP_WSBEiJ_G0019542
protein coding gene Chr13:445022-449677 (-)



Homology
more
  • Human Ortholog
    UCN3, urocortin 3
  • Vertebrate Orthologs
    10
  • Human Ortholog
    UCN3, urocortin 3
    Orthology source: HomoloGene, HGNC
  • Synonyms
    SCP, SPC, UCNIII
  • Links
    NCBI Gene ID: 114131
    neXtProt AC: NX_Q969E3
    UniProt: Q969E3

  • Chr Location
    10p15.1; chr10:5365013-5374206 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 49959
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: UCN3
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    12 phenotypes from 3 alleles in 3 genetic backgrounds
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for one null allele are protected from the hyperinsulinemia, hyperglycemia, glucose intolerance, hepatic steatosis and hypertriglyceridemia induced by a high-fat diet, and show better glucose tolerance as they age. Mice homozygous for another null allele show improved social memory.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 83428 NCBI Gene Model | MGI Sequence Detail 4662 C57BL/6J ±  kb
    transcript NM_031250 RefSeq | MGI Sequence Detail 1478 C57BL/6  
    polypeptide Q924A4 UniProt | EBI | MGI Sequence Detail 164 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 8
      cDNA 7
      Other 1

      Microarray probesets 3
    References
    more
    • Summaries
      All 48
      Developmental Gene Expression 8
      Gene Ontology 7
      Phenotypes 13
    • Earliest
      J:67860 Reyes TM, et al., Urocortin II: a member of the corticotropin-releasing factor (CRF) neuropeptide family that is selectively bound by type 2 CRF receptors. Proc Natl Acad Sci U S A. 2001 Feb 27;98(5):2843-8
    • Latest
      J:242899 Sinagoga KL, et al., Distinct roles for the mTOR pathway in postnatal morphogenesis, maturation and function of pancreatic islets. Development. 2017 Jul 01;144(13):2402-2414

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory