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Ndel1 Gene Detail
Summary
  • Symbol
    Ndel1
  • Name
    nudE neurodevelopment protein 1 like 1
  • Synonyms
    2600006O07Rik, mNudel
  • Feature Type
    protein coding gene
  • IDs
    MGI:1932915
    NCBI Gene: 83431
  • Gene Overview
    MyGene.info: NDEL1
Location & Maps
more
  • Sequence Map
    Chr11:68821434-68871858 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      50425 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 42.09 cM
  • Detailed Genetic Map ± 1 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    NDEL1, nudE neurodevelopment protein 1 like 1
  • Vertebrate Orthologs
    11
  • Human Ortholog
    NDEL1, nudE neurodevelopment protein 1 like 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    EOPA, MITAP1, NDE1L1, NDE2, NUDEL
  • Links
    NCBI Gene ID: 81565
    neXtProt AC: NX_Q9GZM8

  • Chr Location
    17p13.1; chr17:8435852-8471708 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 32567
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;2 zebrafish
  • HCOP
    human homology predictions: NDEL1
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    4 phenotypes from 3 alleles in 1 genetic background
    5 phenotypes from multigenic genotypes
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    21
  • Chemically induced (other)
    1
  • Gene trapped
    13
  • Targeted
    7
  • Genomic Mutations
    1 involving Ndel1
  • Incidental Mutations
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000005956 VEGA Gene Model | MGI Sequence Detail 50425 C57BL/6J ±  kb
transcript OTTMUST00000013283 VEGA | MGI Sequence Detail 2382 Not Applicable  
polypeptide OTTMUSP00000006155 VEGA | MGI Sequence Detail 345 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    374 from dbSNP Build 142
Protein
Information
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  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000011052 nuclear distribution protein nudE-like 1
  • InterPro Domains
    IPR006964 NUDE protein, C-terminal
Molecular
Reagents
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  • All nucleic 14
    cDNA 12
    Primer pair 2

    Microarray probesets 7
Other
Accession IDs
less
MGI:1919693
References
more
  • Summaries
    All 64
    Developmental Gene Expression 18
    Gene Ontology 18
    Phenotypes 18
  • Earliest
    J:66487 Niethammer M, et al., NUDEL is a novel Cdk5 substrate that associates with LIS1 and cytoplasmic dynein. Neuron. 2000 Dec;28(3):697-711
  • Latest
    J:219862 Okamoto M, et al., DBZ regulates cortical cell positioning and neurite development by sustaining the anterograde transport of Lis1 and DISC1 through control of Ndel1 dual-phosphorylation. J Neurosci. 2015 Feb 18;35(7):2942-58

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/24/2016
MGI 6.04
The Jackson Laboratory