Ndel1
Gene Detail

Symbol Name ID

Ndel1 nuclear distribution gene E-like homolog 1 (A. nidulans) MGI:1932915

Synonyms

2600006O07Rik, mNudel

Feature Type

protein coding gene

Genetic Map

Chromosome 11

42.09 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr11:68821434-68871858 bp, - strand From VEGA annotation of GRCm38   50425 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:32567  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 zebrafish

Gene Tree: Ndel1

Human homologs

Human Homolog		NDEL1, nudE nuclear distribution E homolog (A. nidulans)-like 1
NCBI Gene ID		81565
neXtProt AC		NX_Q9GZM8
Human Synonyms		EOPA, MITAP1, NUDEL
Human Chr (Location)		17p13.1; chr17:8339170-8371495 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(19) : Targeted(6) Gene trapped(13)
 

Mice homozygous for a knock-out allele exhibit embryonic lethality.

 

Gene Ontology (GO) classifications

All GO classifications: (49 annotations)

Process	activation of Cdc42 GTPase activity, cell differentiation, ...
Component	axon, cell body, ...
Function	alpha-tubulin binding, beta-tubulin binding, ...

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (14 records)
Data Summary: Results (184)    Tissues (110)    Images (42)
Theiler Stages: 1, 5, 11, 13, 22, 23, 28

Assay Type	Results
RNA in situ	177
Western blot	4
RT-PCR	3

cDNA source data(9)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(11) cDNA(9) Primer pair(2)
Microarray probesets(7)

Other database links

VEGA Gene Model	OTTMUSG00000005956 (Evidence)
Ensembl Gene Model	ENSMUSG00000018736 (Evidence)
Entrez Gene	83431 (Evidence)
DFCI	TC1572502, TC1586683, TC1619703
DoTS	DT.101398454, DT.492802, DT.91570287, DT.97412112
NIA Mouse Gene Index	U032947
Consensus CDS Project	CCDS24870.1
International Mouse Knockout Project Status	Ndel1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000005956	VEGA Gene Model | MGI Sequence Detail	50425	C57BL/6J
transcript	OTTMUST00000013283	VEGA | MGI Sequence Detail	2382	Not Applicable
polypeptide	OTTMUSP00000006155	VEGA | MGI Sequence Detail	345	Not Applicable

All sequences(53) RefSeq(2) UniProt(1)

Polymorphisms

SNPs(142 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR006964	NUDE protein, C-terminal
Protein Ontology	PR:000011052	nuclear distribution protein nudE-like 1

References

(Earliest) J:66487 Niethammer M, et al., NUDEL is a novel Cdk5 substrate that associates with LIS1 and cytoplasmic dynein. Neuron. 2000 Dec;28(3):697-711
(Latest) J:186615 Takitoh T, et al., Activation of Aurora-A Is Essential for Neuronal Migration via Modulation of Microtubule Organization. J Neurosci. 2012 Aug 8;32(32):11050-11066
All references(59)

Other accession IDs

MGI:1919693