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Glis2 Gene Detail
Summary
  • Symbol
    Glis2
  • Name
    GLIS family zinc finger 2
  • Synonyms
    MGC:36775, Nkl
  • Feature Type
    protein coding gene
  • IDs
    MGI:1932535
    NCBI Gene: 83396
Location & Maps
more
  • Sequence Map
    Chr16:4594713-4624924 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      30212 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 16, 2.45 cM, cytoband A1-B1
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    GLIS2, GLIS family zinc finger 2
  • Vertebrate Orthologs
    8
  • Human Ortholog
    GLIS2, GLIS family zinc finger 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    NKL, NPHP7
  • Links
    NCBI Gene ID: 84662
    neXtProt AC: NX_Q9BZE0

  • Chr Location
    16p13.3; chr16:4316181-4339597 (+)  GRCh38.p2
Human Diseases
more
  • Diseases
    1 with Glis2 mouse models; 1 with human GLIS2 associations

Human Disease Mouse Models
       Nephronophthisis 7; NPHP7   OMIM: 611498 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    26 phenotypes from 2 alleles in 2 genetic backgrounds
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a fusion allele exhibit decreased kidney weight, kidney atrophy, kidney cysts, and interstitial fibrosis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    32
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    153
  • Tissues
    149
  • cDNA Data
    92
  • Literature Summary
    5
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000026679 VEGA Gene Model | MGI Sequence Detail 30212 C57BL/6J ±  kb
transcript OTTMUST00000066014 VEGA | MGI Sequence Detail 3619 Not Applicable  
polypeptide OTTMUSP00000032989 VEGA | MGI Sequence Detail 521 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    145 from dbSNP Build 142
Protein
Information
less
  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000008035 zinc finger protein GLIS2
  • InterPro Domains
    IPR007087 Zinc finger, C2H2
    IPR015880 Zinc finger, C2H2-like
    IPR013087 Zinc finger C2H2-type/integrase DNA-binding domain
Molecular
Reagents
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  • All nucleic 95
    cDNA 93
    Primer pair 1
    Other 1

    Microarray probesets 4
References
more
  • Summaries
    All 38
    Developmental Gene Expression 5
    Diseases 1
    Gene Ontology 10
    Phenotypes 12
  • Earliest
    J:67967 Lamar E, et al., Identification of NKL, a novel Gli-Kruppel zinc-finger protein that promotes neuronal differentiation. Development. 2001 Apr;128(8):1335-46
  • Latest
    J:176685 Li Binghua, et al., Increased hedgehog signaling in postnatal kidney results in aberrant activation of nephron developmental programs. Hum Mol Genet. 2011 Nov 1;20(21):4155-66
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/27/2016
MGI 6.05 		The Jackson Laboratory