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Glis2 Gene Detail
Summary
  • Symbol
    Glis2
  • Name
    GLIS family zinc finger 2
  • Synonyms
    MGC:36775, Nkl
  • Feature Type
    protein coding gene
  • IDs
    MGI:1932535
    NCBI Gene: 83396
  • Alliance
    gene page
Location & Maps
more
  • Sequence Map
    Chr16:4594713-4624924 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      30212 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 16, 2.45 cM, cytoband A1-B1
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    GLIS2, GLIS family zinc finger 2
  • Vertebrate Orthologs
    8
  • Human Ortholog
    GLIS2, GLIS family zinc finger 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    NKL, NPHP7
  • Links
    NCBI Gene ID: 84662
    neXtProt AC: NX_Q9BZE0
    UniProt: Q9BZE0

  • Chr Location
    16p13.3; chr16:4314761-4339597 (+)  GRCh38.p7
Human Diseases
more
  • Diseases
    1 with Glis2 mouse models; 1 with human GLIS2 associations

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    26 phenotypes from 2 alleles in 2 genetic backgrounds
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a fusion allele exhibit decreased kidney weight, kidney atrophy, kidney cysts, and interstitial fibrosis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    31
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    153
  • Tissues
    149
  • cDNA Data
    92
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000026679 VEGA Gene Model | MGI Sequence Detail 30212 C57BL/6J ±  kb
    transcript OTTMUST00000066014 VEGA | MGI Sequence Detail 3619 Not Applicable  
    polypeptide OTTMUSP00000032989 VEGA | MGI Sequence Detail 521 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      145 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 95
      cDNA 93
      Primer pair 1
      Other 1

      Microarray probesets 4
    References
    more
    • Summaries
      All 39
      Developmental Gene Expression 5
      Diseases 1
      Gene Ontology 10
      Phenotypes 12
    • Earliest
      J:67967 Lamar E, et al., Identification of NKL, a novel Gli-Kruppel zinc-finger protein that promotes neuronal differentiation. Development. 2001 Apr;128(8):1335-46
    • Latest
      J:176685 Li Binghua, et al., Increased hedgehog signaling in postnatal kidney results in aberrant activation of nephron developmental programs. Hum Mol Genet. 2011 Nov 1;20(21):4155-66
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    05/15/2018
    MGI 6.12     		The Jackson Laboratory