Glis2
Gene Detail

Symbol

Name
ID

Glis2
GLIS family zinc finger 2
MGI:1932535

Synonyms

MGC:36775, Nkl

Feature Type

protein coding gene

Genetic Map

Chromosome 16
2.45 cM, cytoband A1-B1
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr16:4594713-4624924 bp, + strand From VEGA annotation of GRCm38   30212 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate
homology

HomoloGene:12821  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

Gene Tree: Glis2

Human
homologs

Human Homolog		GLIS2, GLIS family zinc finger 2
NCBI Gene ID		84662
neXtProt AC		NX_Q9BZE0
Human Synonyms		NKL, NPHP7
Human Chr (Location)		16p13.3; chr16:4316224-4339597 (+)  GRCh38
Disease Associations		(1) Diseases Associated with Human GLIS2

Mutations,
alleles, and
phenotypes

All mutations/alleles(123) : Gene trapped(116) Targeted(7)
Incidental mutations (data from Mutagenetix , APF )
 

Mice homozygous for a fusion allele exhibit decreased kidney weight, kidney atrophy, kidney cysts, and interstitial fibrosis.

 
Human Diseases Modeled in Mice Using Glis2 (1)    Mutations Annotated to Human Diseases (1)   

Interactions

Glis2 interacts with 229 markers (Mir1a-1, Mir1a-2, Mir9-1, ...)

View All

Gene Ontology
(GO)
classifications

All GO classifications: (25 annotations)

Process	cell differentiation, multicellular organismal development, ...
Component	cytoplasm, nuclear speck, ...
Function	DNA binding, metal ion binding, ...

External Resources: FuncBase

Expression

Literature Summary: (5 records)

Data Summary: Results (153)    Tissues (149)    Images (30)    Tissue x Stage Matrix (view)

Assay Type	Results
RNA in situ	145
RT-PCR	8

cDNA source data(92)
External Resources: Allen Institute   GEO   Expression Atlas

Molecular
reagents

All nucleic(95) cDNA(93) Primer pair(1) Other(1)
Microarray probesets(4)

Other database
links

VEGA Gene Model	OTTMUSG00000026679 (Evidence)
Ensembl Gene Model	ENSMUSG00000014303 (Evidence)
Entrez Gene	83396 (Evidence)
UniGene	134072
DFCI	TC1626919, TC1575846, TC1626105
DoTS	DT.101308508, DT.530167, DT.101736232, DT.91350587
NIA Mouse Gene Index	U016759
Consensus CDS Project	CCDS27920.1
International Mouse Knockout Project Status	Glis2

Sequences

Length	Strain/Species
genomic	OTTMUSG00000026679	VEGA Gene Model | MGI Sequence Detail	30212	C57BL/6J
transcript	OTTMUST00000066014	VEGA | MGI Sequence Detail	3619	Not Applicable
polypeptide	OTTMUSP00000032989	VEGA | MGI Sequence Detail	521	Not Applicable

All sequences(47) RefSeq(10) UniProt(2)

Polymorphisms

SNPs within 2kb(145 from dbSNP Build 137)

Protein-related
information

Resource	ID	Description
InterPro	IPR007087	Zinc finger, C2H2
InterPro	IPR015880	Zinc finger, C2H2-like
InterPro	IPR013087	Zinc finger C2H2-type/integrase DNA-binding domain
Protein Ontology	PR:000008035	zinc finger protein GLIS2

References

(Earliest) J:67967 Lamar E, et al., Identification of NKL, a novel Gli-Kruppel zinc-finger protein that promotes neuronal differentiation. Development. 2001 Apr;128(8):1335-46
(Latest) J:176685 Li Binghua, et al., Increased hedgehog signaling in postnatal kidney results in aberrant activation of nephron developmental programs. Hum Mol Genet. 2011 Nov 1;20(21):4155-66
All references(43)
Disease annotation references (1)