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Glis2
Gene Detail
 Symbol
Name
ID
Glis2
GLIS family zinc finger 2
MGI:1932535
Synonyms MGC:36775, Nkl
Feature Type protein coding gene
Genetic Map
Chromosome 16
2.45 cM, cytoband A1-B1
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr16:4594713-4624924 bp, + strand
From VEGA annotation of GRCm38

  30212 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:12821  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 zebrafish

Gene Tree: Glis2

Human
homologs
Human Homolog GLIS2, GLIS family zinc finger 2
NCBI Gene ID 84662
neXtProt AC  NX_Q9BZE0
Human Synonyms  NKL, NPHP7
Human Chr (Location)  16p13.3; chr16:4316224-4339597 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human GLIS2
Mutations,
alleles, and
phenotypes
All mutations/alleles(123) : Gene trapped(116) Targeted(7)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a fusion allele exhibit decreased kidney weight, kidney atrophy, kidney cysts, and interstitial fibrosis.
 
Human Diseases Modeled Using Mouse Glis2 (1)    Alleles Annotated to Human Diseases(1)   
Interactions
Glis2 interacts with 229 markers (Mir1a-1, Mir1a-2, Mir9-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (25 annotations)
Process cell differentiation, multicellular organismal development, ...
Component cytoplasm, nuclear speck, ...
Function DNA binding, metal ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (160)    Tissues (151)    Images (30)
Theiler Stages: 2, 3, 4, 5, 15, 17, 20, 21, 22, 24, 26, 28
Assay TypeResults
RNA in situ 145
RT-PCR 15
cDNA source data(92)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(95) cDNA(93) Primer pair(1) Other(1)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000026679 (Evidence)
Ensembl Gene ModelENSMUSG00000014303 (Evidence)
Entrez Gene83396 (Evidence)
UniGene134072
DFCITC1575846, TC1626105, TC1626919
DoTSDT.101308508, DT.101736232, DT.530167, DT.91350587
NIA Mouse Gene IndexU016759
Consensus CDS ProjectCCDS27920.1
International Mouse Knockout Project StatusGlis2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000026679 VEGA Gene Model | MGI Sequence Detail 30212 C57BL/6J ±  kb
transcript OTTMUST00000066014 VEGA | MGI Sequence Detail 3619 Not Applicable 
polypeptide OTTMUSP00000032989 VEGA | MGI Sequence Detail 521 Not Applicable 

For the selected sequences
All sequences(47) RefSeq(10) UniProt(2)
Polymorphisms SNPs within 2kb(145 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR007087 Zinc finger, C2H2
InterPro IPR015880 Zinc finger, C2H2-like
InterPro IPR013087 Zinc finger C2H2-type/integrase DNA-binding domain
Protein Ontology PR:000008035 zinc finger protein GLIS2
References (Earliest) J:67967 Lamar E, et al., Identification of NKL, a novel Gli-Kruppel zinc-finger protein that promotes neuronal differentiation. Development. 2001 Apr;128(8):1335-46
(Latest) J:176685 Li Binghua, et al., Increased hedgehog signaling in postnatal kidney results in aberrant activation of nephron developmental programs. Hum Mol Genet. 2011 Nov 1;20(21):4155-66
All references(43)
Disease annotation references (1)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/23/2014
MGI 5.19
The Jackson Laboratory