Glis2 MGI Mouse Gene Detail - MGI:1932535 - GLIS family zinc finger 2

Symbol

Glis2
Name

GLIS family zinc finger 2
Synonyms

MGC:36775, Nkl

Feature Type

protein coding gene
IDs

MGI:1932535
NCBI Gene: 83396
Alliance

gene page
Transcription Start Sites

3 TSS

Sequence Map

Chr16:4594713-4624924 bp, + strand
From Ensembl annotation of GRCm38

View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 16, 2.45 cM, cytoband A1-B1
Mapping Data

2 experiments

SNPs within 2kb

145 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1932535	protein coding gene	Chr16:4594320-4625141 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0022465	protein coding gene	Chr16:1090552-1126217 (+)
A/J	MGP_AJ_G0022427	protein coding gene	Chr16:921440-951594 (+)
AKR/J	MGP_AKRJ_G0022404	protein coding gene	Chr16:1104535-1134694 (+)
BALB/cJ	MGP_BALBcJ_G0022432	protein coding gene	Chr16:1074900-1105160 (+)
C3H/HeJ	MGP_C3HHeJ_G0022199	protein coding gene	Chr16:1125280-1155865 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0022881	protein coding gene	Chr16:1157000-1205358 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0020402	protein coding gene	Chr16:862614-892962 (+)
CAST/EiJ	MGP_CASTEiJ_G0021725	protein coding gene	Chr16:1110749-1144355 (+)
CBA/J	MGP_CBAJ_G0022168	protein coding gene	Chr16:1237197-1267369 (+)
DBA/2J	MGP_DBA2J_G0022299	protein coding gene	Chr16:1032306-1062435 (+)
FVB/NJ	MGP_FVBNJ_G0022274	protein coding gene	Chr16:1017089-1047781 (+)
LP/J	MGP_LPJ_G0022367	protein coding gene	Chr16:1097692-1129877 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0022296	protein coding gene	Chr16:1107269-1139792 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0022893	protein coding gene	Chr16:1073206-1104241 (+)
PWK/PhJ	MGP_PWKPhJ_G0021465	protein coding gene	Chr16:1091794-1122816 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0021296	protein coding gene	Chr16:1163575-1193795 (+)
WSB/EiJ	MGP_WSBEiJ_G0021774	protein coding gene	Chr16:1087270-1117237 (+)

Human Ortholog

GLIS2, GLIS family zinc finger 2

Vertebrate Orthologs

8

Human Ortholog

GLIS2, GLIS family zinc finger 2
Orthology source: HomoloGene, HGNC
Synonyms

NKL, NPHP7
Links

HGNC:29450

NCBI Gene ID: 84662

neXtProt AC: NX_Q9BZE0

UniProt: Q9BZE0
Chr Location

16p13.3; chr16:4314761-4339597 (+) GRCh38.p7

HomoloGene

Vertebrate Homology Class 12821
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 zebrafish;1 frog, western clawed
HCOP

human homology predictions: GLIS2
Gene Tree

Glis2

Diseases

1 with Glis2 mouse models; 1 with human GLIS2 associations

Human Disease

Mouse Models

nephronophthisis 7

IDs

View 1 model

Click on a disease name to see all genes associated with that disease.

Mutations/Alleles

1 with disease annotations

References

1 with disease annotations

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Phenotype Summary

26 phenotypes from 2 alleles in 2 genetic backgrounds
14 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

123
Gene trapped

116
Targeted

7
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

94 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a fusion allele exhibit decreased kidney weight, kidney atrophy, kidney cysts, and interstitial fibrosis.

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All GO Annotations

36
GO References

11

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell death	cell differentiation	cell population proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	nucleic acid-templated transcription	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

155
Tissues

151
cDNA Data

93
Literature Summary

6

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

ZFIN glis2a, glis2b

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Glis2 interacts with 229 markers (Mir1a-1, Mir1a-2, Mir9-1, ...) View All

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All Sequences

49
RefSeq

10
UniProt

2
CCDS

CCDS27920.1
UniGene

134072

Ensembl

ENSMUSG00000014303 (Evidence)
NCBI Gene

83396

			Length	Strain/Species	Flank
genomic	ENSMUSG00000014303	Ensembl Gene Model \| MGI Sequence Detail	30212	C57BL/6J	± kb
transcript	ENSMUST00000014447	Ensembl \| MGI Sequence Detail	3619	Not Applicable
polypeptide	ENSMUSP00000014447	Ensembl \| MGI Sequence Detail	521	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000008035 zinc finger protein GLIS2

(term hierarchy)
InterPro Domains

IPR036236 Zinc finger C2H2 superfamily

IPR013087 Zinc finger C2H2-type

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All nucleic 96

cDNA 94

Primer pair 1

Other 1

Microarray probesets 4

Summaries

All 43

Developmental Gene Expression 6

Diseases 1

Gene Ontology 11

Phenotypes 14
Earliest

J:67967 Lamar E, et al., Identification of NKL, a novel Gli-Kruppel zinc-finger protein that promotes neuronal differentiation. Development. 2001 Apr;128(8):1335-46
Latest

J:261559 Shima H, et al., Ring1A and Ring1B inhibit expression of Glis2 to maintain murine MOZ-TIF2 AML stem cells. Blood. 2018 Apr 19;131(16):1833-1845

TSS for Glis2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr136858	Chr16:4594683-4594735 (+)	-4 bp
Tssr136859	Chr16:4594740-4594759 (+)	37 bp
Tssr136860	Chr16:4594853-4594884 (+)	156 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer & Copyright Notice Send questions and comments to User Support.	last database update 02/18/2020 MGI 6.14