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Glis2 Gene Detail
Summary
  • Symbol
    Glis2
  • Name
    GLIS family zinc finger 2
  • Synonyms
    MGC:36775, Nkl
  • Feature Type
    protein coding gene
  • IDs
    MGI:1932535
    NCBI Gene: 83396
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:4412577-4442788 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 16, 2.45 cM, cytoband A1-B1
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1004 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1932535
 protein coding gene Chr16:4412217-4443076 (+)
129S1/SvImJ MGP_129S1SvImJ_G0022465
 protein coding gene Chr16:1090552-1126217 (+)
A/J MGP_AJ_G0022427
 protein coding gene Chr16:921440-951594 (+)
AKR/J MGP_AKRJ_G0022404
 protein coding gene Chr16:1104535-1134694 (+)
BALB/cJ MGP_BALBcJ_G0022432
 protein coding gene Chr16:1074900-1105160 (+)
C3H/HeJ MGP_C3HHeJ_G0022199
 protein coding gene Chr16:1125280-1155865 (+)
C57BL/6NJ MGP_C57BL6NJ_G0022881
 protein coding gene Chr16:1157000-1205358 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0020402
 protein coding gene Chr16:862614-892962 (+)
CAST/EiJ MGP_CASTEiJ_G0021725
 protein coding gene Chr16:1110749-1144355 (+)
CBA/J MGP_CBAJ_G0022168
 protein coding gene Chr16:1237197-1267369 (+)
DBA/2J MGP_DBA2J_G0022299
 protein coding gene Chr16:1032306-1062435 (+)
FVB/NJ MGP_FVBNJ_G0022274
 protein coding gene Chr16:1017089-1047781 (+)
LP/J MGP_LPJ_G0022367
 protein coding gene Chr16:1097692-1129877 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0022296
 protein coding gene Chr16:1107269-1139792 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0022893
 protein coding gene Chr16:1073206-1104241 (+)
PWK/PhJ MGP_PWKPhJ_G0021465
 protein coding gene Chr16:1091794-1122816 (+)
SPRET/EiJ MGP_SPRETEiJ_G0021296
 protein coding gene Chr16:1163575-1193795 (+)
WSB/EiJ MGP_WSBEiJ_G0021774
 protein coding gene Chr16:1087270-1117237 (+)



Homology
more
  • Human Ortholog
    GLIS2, GLIS family zinc finger 2
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GLIS2, GLIS family zinc finger 2
  • Synonyms
    NKL, NPHP7
  • Links
    NCBI Gene ID: 84662
    UniProt: Q9BZE0

  • Chr Location
    16p13.3; chr16:4314761-4339597 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Glis2 mouse models; 1 with human GLIS2 associations

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    26 phenotypes from 2 alleles in 2 genetic backgrounds
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a fusion allele exhibit decreased kidney weight, kidney atrophy, kidney cysts, and interstitial fibrosis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    51
  • GO References
    16
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    869
  • Tissues
    154
  • cDNA Data
    93
  • Literature Summary
    7
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000014303 Ensembl Gene Model | MGI Sequence Detail 30212 C57BL/6J ±  kb
    transcript ENSMUST00000014447 Ensembl | MGI Sequence Detail 3619 Not Applicable  
    polypeptide ENSMUSP00000014447 Ensembl | MGI Sequence Detail 521 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 97
      cDNA 94
      Primer pair 2
      Other 1

      Microarray probesets 4
    References
    more
    • Summaries
      All 53
      Developmental Gene Expression 7
      Diseases 1
      Gene Ontology 16
      Phenotypes 17
    • Earliest
      J:67967 Lamar E, et al., Identification of NKL, a novel Gli-Kruppel zinc-finger protein that promotes neuronal differentiation. Development. 2001 Apr;128(8):1335-46
    • Latest
      J:348977 Zhang C, et al., Glis2 is an early effector of polycystin signaling and a target for therapy in polycystic kidney disease. Nat Commun. 2024 May 1;15(1):3698
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    03/25/2025
    MGI 6.24     		The Jackson Laboratory