Go Annotations as Summary Text (Tabular View) (GO Graph)

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Automated description from the Alliance of Genome Resources (Release 8.3.0)

Enables DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription repressor activity, RNA polymerase II-specific; and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in negative regulation of DNA-templated transcription; negative regulation of smoothened signaling pathway; and positive regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including hematopoietic stem cell homeostasis; negative regulation of transcription by RNA polymerase II; and positive regulation of protein localization to nucleus. Located in cytoplasm; non-motile cilium; and nuclear speck. Is expressed in several structures, including early conceptus; metanephros; nervous system; oocyte; and retina layer. Used to study nephronophthisis 7. Human ortholog(s) of this gene implicated in nephronophthisis 7. Orthologous to human GLIS2 (GLIS family zinc finger 2).

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Gene Ontology Evidence Code Abbreviations:

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