Il23a
Gene Detail

Symbol Name ID

Il23a interleukin 23, alpha subunit p19 MGI:1932410

Synonyms

IL-23, IL-23p19, p19

Feature Type

protein coding gene

Genetic Map

Chromosome 10

76.51 cM, cytoband D3
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

Chr10:128296140-128298084 bp, - strand From NCBI annotation of GRCm38   1945 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:12832  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Protein SuperFamily: interleukin 23, subunit alpha
Gene Tree: Il23a

Human homologs

Human Homolog		IL23A, interleukin 23, alpha subunit p19
NCBI Gene ID		51561
neXtProt AC		NX_Q9NPF7
Human Synonyms		IL-23, IL-23A, IL23P19, P19, SGRF
Human Chr (Location)		12q13.3; chr12:56732663-56734194 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(41) : Targeted(7) Gene trapped(34)
 

Homozygous null mice are resistant to experimental autoimmune encephalomyelitis and have inefficient responses by CD4+ T cells.

 

Gene Ontology (GO) classifications

All GO classifications: (44 annotations)

Process	defense response to Gram-negative bacterium, defense response to virus, ...
Component	extracellular region, extracellular space, ...
Function	cytokine activity, interleukin-23 receptor binding, ...

External Resources: FuncBase

Expression

Literature Summary: (1 records)
Data Summary: Results (16)    Tissues (7)   
Theiler Stages: 6, 8, 28

Assay Type	Results
RT-PCR	16

cDNA source data(8)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(9) cDNA(8) Primer pair(1)
Microarray probesets(2)

Other database links

Ensembl Gene Model	ENSMUSG00000025383 (Evidence)
Entrez Gene	83430 (Evidence)
UniGene	125482
DFCI	TC1587028, TC1715765
DoTS	DT.101722065, DT.87029242
NIA Mouse Gene Index	U032350
Consensus CDS Project	CCDS24270.1
International Mouse Knockout Project Status	Il23a

Sequences

Length	Strain/Species
genomic	83430	NCBI Gene Model | MGI Sequence Detail	1945	C57BL/6J
transcript	NM_031252	RefSeq | MGI Sequence Detail	1359	C57BL/6
polypeptide	Q9EQ14	UniProt | EBI | MGI Sequence Detail	196	Not Applicable

All sequences(15) RefSeq(2) UniProt(1)

Polymorphisms

SNPs(19 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR012351	Four-helical cytokine, core
InterPro	IPR009079	Four-helical cytokine-like, core
InterPro	IPR010831	Interleukin 23 alpha subunit p19
InterPro	IPR003573	Interleukin-6/G-CSF/MGF
Protein Ontology	PR:000001384	interleukin-23 subunit alpha

Graphical View of Protein Domain Structure

References

(Earliest) J:65966 Oppmann B, et al., Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12. Immunity. 2000 Nov;13(5):715-25
(Latest) J:194909 Hirota K, et al., Plasticity of TH17 cells in Peyer's patches is responsible for the induction of T cell-dependent IgA responses. Nat Immunol. 2013 Apr;14(4):372-9
All references(130)