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Il23a Gene Detail
Summary
  • Symbol
    Il23a
  • Name
    interleukin 23, alpha subunit p19
  • Synonyms
    IL-23, IL-23p19, p19
  • Feature Type
    protein coding gene
  • IDs
    MGI:1932410
    NCBI Gene: 83430
  • Gene Overview
    MyGene.info: IL23A
Location & Maps
more
  • Sequence Map
    Chr10:128296140-128298084 bp, - strand
  • From NCBI annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      1945 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    IL23A, interleukin 23 subunit alpha
  • Vertebrate Orthologs
    7
  • Human Ortholog
    IL23A, interleukin 23 subunit alpha
    Orthology source: HomoloGene
  • Synonyms
    IL-23, IL-23A, IL23P19, P19, SGRF
  • Links
    NCBI Gene ID: 51561
    neXtProt AC: NX_Q9NPF7

  • Chr Location
    12q13.3; chr12:56334158-56340410 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    30 phenotypes from 5 alleles in 8 genetic backgrounds
    2 phenotypes from multigenic genotypes
    103 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    43
  • Gene trapped
    34
  • Targeted
    9
Homozygous null mice are resistant to experimental autoimmune encephalomyelitis and have inefficient responses by CD4+ T cells.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 83430 NCBI Gene Model | MGI Sequence Detail 1945 C57BL/6J ±  kb
transcript NM_031252 RefSeq | MGI Sequence Detail 1359 C57BL/6  
polypeptide Q9EQ14 UniProt | EBI | MGI Sequence Detail 196 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    37 from dbSNP Build 142
Protein
Information
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  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000001384 interleukin-23 subunit alpha
  • InterPro Domains
    IPR012351 Four-helical cytokine, core
    IPR009079 Four-helical cytokine-like, core
    IPR010831 Interleukin-23 alpha
Molecular
Reagents
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  • All nucleic 9
    cDNA 8
    Primer pair 1

    Microarray probesets 2
References
more
  • Summaries
    All 160
    Developmental Gene Expression 1
    Gene Ontology 11
    Phenotypes 103
  • Earliest
    J:65966 Oppmann B, et al., Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12. Immunity. 2000 Nov;13(5):715-25
  • Latest
    J:229771 Kobayashi T, et al., Dysbiosis and Staphylococcus aureus Colonization Drives Inflammation in Atopic Dermatitis. Immunity. 2015 Apr 21;42(4):756-66

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/19/2016
MGI 6.03
The Jackson Laboratory