Il23a MGI Mouse Gene Detail - MGI:1932410 - interleukin 23, alpha subunit p19

Symbol

Il23a
Name

interleukin 23, alpha subunit p19
Synonyms

IL-23, IL-23p19, p19

Feature Type

protein coding gene
IDs

MGI:1932410
NCBI Gene: 83430
Alliance

genome feature page
Transcription Start Sites

1 TSS

Sequence Map

Chr10:128132009-128133953 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 10, 76.51 cM, cytoband D3
Mapping Data

1 experiment

SNPs within 2kb

82 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1932410	protein coding gene	Chr10:128132008-128134621 (-)
129S1/SvImJ	ENSMUSG00200009379	protein coding gene	Chr10:124486172-124488116 (-)
A/J	ENSMUSG00195013286	protein coding gene	Chr10:124949417-124951361 (-)
AKR/J	ENSMUSG00220004438	protein coding gene	Chr10:124554909-124556854 (-)
BALB/cJ	ENSMUSG00180010327	protein coding gene	Chr10:124940386-124942330 (-)
C3H/HeJ	ENSMUSG00175005969	protein coding gene	Chr10:124939717-124941661 (-)
C57BL/6NJ	ENSMUSG00215007063	protein coding gene	Chr10:124550420-124552365 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0015929	protein coding gene	Chr10:120655299-120657232 (-)
CAST/EiJ	ENSTCUG00005036690	protein coding gene	Chr10:123937985-123939928 (-)
CBA/J	ENSMUSG00210009034	protein coding gene	Chr10:124763928-124765872 (-)
DBA/2J	ENSMUSG00185025109	protein coding gene	Chr10:124917750-124919695 (-)
FVB/NJ	ENSMUSG00205019751	protein coding gene	Chr10:124159670-124161615 (-)
JF1/MsJ	ENSUMUG00000022535	protein coding gene	Chr10:126227795-126229739 (-)
LP/J	ENSMUSG00230032664	protein coding gene	Chr10:126839924-126841869 (-)
NOD/ShiLtJ	ENSMUSG00190014139	protein coding gene	Chr10:124981408-124983353 (-)
NZO/HlLtJ	ENSMUSG00225037089	protein coding gene	Chr10:131042327-131044272 (-)
PWK/PhJ	ENSLUMG00010008939	protein coding gene	Chr10:124678942-124680886 (-)
SPRET/EiJ	ENSMSPG00010029724	protein coding gene	Chr10:126643203-126645146 (-)
WSB/EiJ	ENSIUOG00005007890	protein coding gene	Chr10:124556048-124557992 (-)

Human Ortholog

IL23A, interleukin 23 subunit alpha

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

IL23A, interleukin 23 subunit alpha
Synonyms

IL-23, IL-23A, IL23P19, P19, SGRF
Links

HGNC:15488

NCBI Gene ID: 51561

UniProt: Q9NPF7
Chr Location

12q13.3; chr12:56334174-56340410 (+) GRCh38

MGI Vertebrate Homology

Il23a stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: IL23A
Gene Tree

Il23a

Diseases

1 with human IL23A associations

				Human Disease	Mouse Models
				asthma IDs asthma DOID:2841 DOID:12703 DOID:13829 DOID:13830 DOID:2840 DOID:5783 ICD10CM:J45 ICD9CM:493 ICD9CM:493.9 KEGG:05310 MESH:D001249 NCI:C28397 OMIM:600807 UMLS_CUI:C0004096

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

30 phenotypes from 5 alleles in 8 genetic backgrounds
3 phenotypes from multigenic genotypes
163 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

59
Endonuclease-mediated

16
Gene trapped

32
Targeted

11
Find Mice (IMSR)

26 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous null mice are resistant to experimental autoimmune encephalomyelitis and have inefficient responses by CD4+ T cells.

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All GO Annotations

81
GO References

13

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

613
Tissues

7
cDNA Data

9
Literature Summary

2

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

30
RefSeq

2
UniProt

1
CCDS

CCDS24270.1

Ensembl

ENSMUSG00000025383 (Evidence)
NCBI Gene

83430

			Length	Strain/Species	Flank
genomic	83430	NCBI Gene Model \| MGI Sequence Detail	1945	C57BL/6J	± kb
transcript	NM_031252	RefSeq \| MGI Sequence Detail	1359	C57BL/6
polypeptide	Q9EQ14	UniProt \| EBI \| MGI Sequence Detail	196	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000001384 interleukin-23 subunit alpha

(term hierarchy)
InterPro Domains

IPR009079 Four-helical cytokine-like, core

IPR010831 Interleukin-23 alpha

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All nucleic 10

cDNA 9

Primer pair 1

Microarray probesets 2

Summaries

All 347

Developmental Gene Expression 2

Gene Ontology 13

Phenotypes 163
Earliest

J:65966 Oppmann B, et al., Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12. Immunity. 2000 Nov;13(5):715-25
Latest

J:388097 Dillon JT, et al., Synergistic exacerbation of oral mucositis caused by IL-23 deficiency and oral Candida albicans exposure. mBio. 2025 Oct 8;16(10):e0199225

TSS for Il23a:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr99851	Chr10:128133935-128133970 (-)	0 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/08/2026 MGI 6.24