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Il23a
Gene Detail
Symbol

Name
ID
Il23a
interleukin 23, alpha subunit p19
MGI:1932410
Synonyms
IL-23, IL-23p19, p19
Feature Type
protein coding gene
Genetic Map
Chromosome 10
76.51 cM, cytoband D3
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr10:128296140-128298084 bp, - strand
From NCBI annotation of GRCm38

  1945 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:12832  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Protein SuperFamily: interleukin 23, subunit alpha
Gene Tree: Il23a

Human
homologs
Human Homolog IL23A, interleukin 23, alpha subunit p19
NCBI Gene ID 51561
neXtProt AC  NX_Q9NPF7
Human Synonyms  IL-23, IL-23A, IL23P19, P19, SGRF
Human Chr (Location)  12q13.3; chr12:56338879-56340410 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(43) : Gene trapped(34) Targeted(9)
 
Homozygous null mice are resistant to experimental autoimmune encephalomyelitis and have inefficient responses by CD4+ T cells.
 
Interactions
Il23a interacts with 110 markers (Mir7-1, Mir22, Mir24-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (45 annotations)
Process defense response to Gram-negative bacterium, defense response to virus, ...
Component extracellular region, extracellular space, ...
Function cytokine activity, interleukin-23 receptor binding, ...
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (16)    Tissues (7)    Tissue x Stage Matrix (view)
Assay TypeResults
RT-PCR 16
cDNA source data(8)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(9) cDNA(8) Primer pair(1)
Microarray probesets(2)
Other database
links
Ensembl Gene ModelENSMUSG00000025383 (Evidence)
Entrez Gene83430 (Evidence)
UniGene125482
DFCITC1587028, TC1715765
DoTSDT.101722065, DT.87029242
NIA Mouse Gene IndexU032350
Consensus CDS ProjectCCDS24270.1
International Mouse Knockout Project StatusIl23a
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 83430 NCBI Gene Model | MGI Sequence Detail 1945 C57BL/6J ±  kb
transcript NM_031252 RefSeq | MGI Sequence Detail 1359 C57BL/6 
polypeptide Q9EQ14 UniProt | EBI | MGI Sequence Detail 196 Not Applicable 

For the selected sequences
All sequences(15) RefSeq(2) UniProt(1)
Polymorphisms
SNPs within 2kb(38 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR012351 Four-helical cytokine, core
InterPro IPR009079 Four-helical cytokine-like, core
InterPro IPR010831 Interleukin 23 alpha subunit p19
InterPro IPR003573 Interleukin-6/G-CSF/MGF
Protein Ontology PR:000001384 interleukin-23 subunit alpha
Graphical View of Protein Domain Structure
References
(Earliest) J:65966 Oppmann B, et al., Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12. Immunity. 2000 Nov;13(5):715-25
(Latest) J:210830 Yoshiki R, et al., IL-23 from Langerhans Cells Is Required for the Development of Imiquimod-Induced Psoriasis-Like Dermatitis by Induction of IL-17A-Producing gammadelta T Cells. J Invest Dermatol. 2014 Jul;134(7):1912-21
All references(145)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory