About   Help   FAQ
Il23a Gene Detail
Summary
  • Symbol
    Il23a
  • Name
    interleukin 23, alpha subunit p19
  • Synonyms
    IL-23, IL-23p19, p19
  • Feature Type
    protein coding gene
  • IDs
    MGI:1932410
    NCBI Gene: 83430
  • Gene Overview
    MyGene.info: IL23A
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr10:128296140-128298084 bp, - strand
  • From NCBI annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      1945 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 10, 76.51 cM, cytoband D3
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    IL23A, interleukin 23 subunit alpha
  • Vertebrate Orthologs
    7
  • Human Ortholog
    IL23A, interleukin 23 subunit alpha
    Orthology source: HGNC, HomoloGene
  • Synonyms
    IL-23, IL-23A, IL23P19, P19, SGRF
  • Links
    NCBI Gene ID: 51561
    neXtProt AC: NX_Q9NPF7
    UniProt: Q9NPF7

  • Chr Location
    12q13.3; chr12:56334159-56340410 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    30 phenotypes from 5 alleles in 8 genetic backgrounds
    2 phenotypes from multigenic genotypes
    114 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous null mice are resistant to experimental autoimmune encephalomyelitis and have inefficient responses by CD4+ T cells.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 83430 NCBI Gene Model | MGI Sequence Detail 1945 C57BL/6J ±  kb
    transcript NM_031252 RefSeq | MGI Sequence Detail 1359 C57BL/6  
    polypeptide Q9EQ14 UniProt | EBI | MGI Sequence Detail 196 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      37 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 10
      cDNA 9
      Primer pair 1

      Microarray probesets 2
    References
    more
    • Summaries
      All 228
      Developmental Gene Expression 1
      Gene Ontology 11
      Phenotypes 114
    • Earliest
      J:65966 Oppmann B, et al., Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12. Immunity. 2000 Nov;13(5):715-25
    • Latest
      J:263562 Ngo VL, et al., A cytokine network involving IL-36gamma, IL-23, and IL-22 promotes antimicrobial defense and recovery from intestinal barrier damage. Proc Natl Acad Sci U S A. 2018 May 29;115(22):E5076-E5085

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
    Warranty Disclaimer & Copyright Notice
    Send questions and comments to User Support.
    last database update
    09/18/2018
    MGI 6.12
    The Jackson Laboratory