Il23a Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Il23a
interleukin 23, alpha subunit p19
MGI:1932410

30 phenotypes from 5 alleles in 8 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Il23a^tm1.1Thak/Il23a^tm1.1Thak C57BL/6-Il23a^tm1.1Thak	decreased interferon-gamma secretion	J:143970
	decreased interleukin-17 secretion	J:143970
	decreased susceptibility to experimental autoimmune encephalomyelitis	J:143970
	decreased T cell proliferation	J:143970
Il23a^tm1Dnax/Il23a^tm1Dnax B6.Cg-Il23a^tm1Dnax	abnormal CD8-positive, alpha-beta T cell physiology	J:111568
	abnormal granulocyte physiology	J:111568
	abnormal interleukin level	J:111568
	abnormal macrophage physiology	J:111568
	decreased incidence of tumors by chemical induction	J:111568
Il23a^tm1Dnax/Il23a^tm1Dnax involves: 129 * C57BL/6	abnormal CD4-positive, alpha-beta T cell physiology	J:95542
	decreased interleukin-17 secretion	J:95542
	decreased susceptibility to experimental autoimmune encephalomyelitis	J:95542
Il23a^tm1Dnax/Il23a^tm1Dnax Not Specified	decreased gamma-delta T cell number	J:193548
	decreased interleukin-17 secretion	J:193548
	decreased leukocyte cell number	J:193548
	decreased neutrophil cell number	J:193548
	decreased physiological sensitivity to xenobiotic	J:193548
	decreased T cell number	J:193548
Il23a^tm1Gdy/Il23a⁺ B6.Cg-Il23a^tm1Gdy	increased susceptibility to induced colitis	J:139557
Il23a^tm1Gdy/Il23a^tm1Gdy B6.Cg-Il23a^tm1Gdy	increased susceptibility to induced colitis	J:139557
Il23a^tm1Gdy/Il23a^tm1Gdy B6.Cg-Il23a^tm1Gdy	increased susceptibility to xenobiotic induced morbidity/mortality	J:139557
Il23a^tm1Lex/Il23a^tm1Lex involves: 129S5/SvEvBrd * C57BL/6J	no abnormal phenotype detected	J:103485
Il23a^tm1Ngh/Il23a^tm1Ngh involves: 129	increased susceptibility to bacterial infection induced morbidity/mortality	J:161073
Il23a^tm1Ngh/Il23a^tm1Ngh involves: 129 * C57BL/6	abnormal circulating interleukin level	J:216867
	abnormal memory T cell physiology	J:120806
	decreased activated T cell number	J:120806
	decreased physiological sensitivity to xenobiotic	J:216867
	decreased susceptibility to induced colitis	J:216867
	granulomatous inflammation	J:120806
	increased circulating interleukin-17 level	J:216867
	increased susceptibility to bacterial infection	J:120806
Il23a^tm1Ngh/Il23a^tm1Ngh involves: 129S/SvEv * C57BL/6	abnormal CD4-positive, alpha-beta T cell physiology	J:88235
	abnormal CD8-positive, alpha beta T cell morphology	J:88235
	abnormal memory T cell physiology	J:88235
	decreased IgA level	J:88235
	decreased IgG2a level	J:88235
	decreased immunoglobulin level	J:88235

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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