About   Help   FAQ
Celf4 Gene Detail
Summary
  • Symbol
    Celf4
  • Name
    CUGBP, Elav-like family member 4
  • Synonyms
    A230070D14Rik, Brul4, Brunol4, BRUNOL-4, C130060B05Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1932407
    NCBI Gene: 108013
  • Gene Overview
    MyGene.info: CELF4
Location & Maps
more
  • Sequence Map
    Chr18:25477632-25753983 bp, - strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      276352 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 18, 13.92 cM, cytoband B1
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    CELF4, CUGBP, Elav-like family member 4
  • Vertebrate Orthologs
    8
  • Human Ortholog
    CELF4, CUGBP, Elav-like family member 4
    Orthology source: HGNC, HomoloGene
  • Synonyms
    BRUNOL4, CELF-4
  • Links
    NCBI Gene ID: 56853
    neXtProt AC: NX_Q9BZC1

  • Chr Location
    18q12; chr18:37190090-37566037 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    11 phenotypes from 2 alleles in 8 genetic backgrounds
    1 images
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    11
  • Gene trapped
    5
  • Targeted
    5
  • Transgenic
    1
  • Incidental Mutations
Mice homozygous for a null allele exhibit neonatal lethality, shortened life span dependent on genetic background, and seizures. Mice heterozygous for a null allele exhibit complex seizures and abnormal body weights depending on age.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000024268 Ensembl Gene Model | MGI Sequence Detail 276352 C57BL/6J ±  kb
transcript ENSMUST00000115816 Ensembl | MGI Sequence Detail 3995 Not Applicable  
polypeptide ENSMUSP00000111483 Ensembl | MGI Sequence Detail 504 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    583 from dbSNP Build 142
Protein
Information
less
  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000004825 CUGBP Elav-like family member 4
  • InterPro Domains
    IPR012677 Nucleotide-binding alpha-beta plait domain
    IPR000504 RNA recognition motif domain
Molecular
Reagents
less
  • All nucleic 20
    Genomic 1
    cDNA 12
    Primer pair 6
    Other 1

    Microarray probesets 3
Other
Accession IDs
less
MGI:2442678, MGI:2444528
References
more
  • Summaries
    All 44
    Developmental Gene Expression 7
    Gene Ontology 8
    Phenotypes 11
  • Earliest
    J:74955 Good PJ, et al., A family of human RNA-binding proteins related to the Drosophila Bruno translational regulator. J Biol Chem. 2000 Sep 15;275(37):28583-92
  • Latest
    J:206496 Hoekstra EJ, et al., Lmx1a encodes a rostral set of mesodiencephalic dopaminergic neurons marked by the Wnt/B-catenin signaling activator R-spondin 2. PLoS One. 2013;8(9):e74049

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
08/23/2016
MGI 6.05
The Jackson Laboratory