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Celf4 Gene Detail
Summary
  • Symbol
    Celf4
  • Name
    CUGBP, Elav-like family member 4
  • Synonyms
    A230070D14Rik, Brul4, Brunol4, BRUNOL-4, C130060B05Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1932407
    NCBI Gene: 108013
  • Gene Overview
    MyGene.info: CELF4
  • Alliance
  • Transcription Start Sites
    11 TSS
Location &
Maps
more
  • Sequence Map
    Chr18:25477632-25754157 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 18, 13.92 cM, cytoband B1
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    583 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1932407
protein coding gene Chr18:25477620-25754162 (-)
129S1/SvImJ MGP_129S1SvImJ_G0024209
protein coding gene Chr18:23302225-23587764 (-)
A/J MGP_AJ_G0024174
protein coding gene Chr18:22621806-22905503 (-)
AKR/J MGP_AKRJ_G0024143
protein coding gene Chr18:23308437-23592249 (-)
BALB/cJ MGP_BALBcJ_G0024174
protein coding gene Chr18:22691791-22969248 (-)
C3H/HeJ MGP_C3HHeJ_G0023942
protein coding gene Chr18:23247799-23537822 (-)
C57BL/6NJ MGP_C57BL6NJ_G0024616
protein coding gene Chr18:24211538-24507120 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0022058
protein coding gene Chr18:22438263-22715402 (-)
CAST/EiJ MGP_CASTEiJ_G0023416
protein coding gene Chr18:23043397-23326238 (-)
CBA/J MGP_CBAJ_G0023910
protein coding gene Chr18:24891776-25193792 (-)
DBA/2J MGP_DBA2J_G0024042
protein coding gene Chr18:22268827-22548895 (-)
FVB/NJ MGP_FVBNJ_G0024008
protein coding gene Chr18:22047938-22330265 (-)
LP/J MGP_LPJ_G0024123
protein coding gene Chr18:23429088-23719054 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0024036
protein coding gene Chr18:25891002-26183056 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0024664
protein coding gene Chr18:23073143-23360994 (-)
PWK/PhJ MGP_PWKPhJ_G0023160
protein coding gene Chr18:22419290-22705968 (-)
SPRET/EiJ MGP_SPRETEiJ_G0022969
protein coding gene Chr18:23265628-23560533 (-)
WSB/EiJ MGP_WSBEiJ_G0023480
protein coding gene Chr18:22957329-23245422 (-)



Homology
more
  • Human Ortholog
    CELF4, CUGBP Elav-like family member 4
  • Vertebrate Orthologs
    8
  • Human Ortholog
    CELF4, CUGBP Elav-like family member 4
    Orthology source: HomoloGene, HGNC
  • Synonyms
    BRUNOL4, CELF-4
  • Links
    NCBI Gene ID: 56853
    neXtProt AC: NX_Q9BZC1
    UniProt: Q9BZC1

  • Chr Location
    18q12.2; chr18:37243040-37566052 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    28 phenotypes from 4 alleles in 13 genetic backgrounds
    1 images
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit neonatal lethality, shortened life span dependent on genetic background, and seizures. Mice heterozygous for a null allele exhibit complex seizures and abnormal body weights depending on age.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000024268 Ensembl Gene Model | MGI Sequence Detail 276526 C57BL/6J ±  kb
    transcript ENSMUST00000115816 Ensembl | MGI Sequence Detail 3995 Not Applicable  
    polypeptide ENSMUSP00000111483 Ensembl | MGI Sequence Detail 504 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 25
      Genomic 1
      cDNA 14
      Primer pair 8
      Other 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2442678, MGI:2444528
    References
    more
    • Summaries
      All 52
      Developmental Gene Expression 8
      Gene Ontology 10
      Phenotypes 15
    • Earliest
      J:19671 Yulug IG, et al., Mapping GRB2, a signal transduction gene in the human and the mouse. Genomics. 1994 Jul 15;22(2):313-8
    • Latest
      J:261316 Perez-Garcia V, et al., Placentation defects are highly prevalent in embryonic lethal mouse mutants. Nature. 2018 Mar 22;555(7697):463-468

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/13/2018
    MGI 6.13
    The Jackson Laboratory