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Celf4 Gene Detail
Summary
  • Symbol
    Celf4
  • Name
    CUGBP, Elav-like family member 4
  • Synonyms
    A230070D14Rik, Brul4, Brunol4, BRUNOL-4, C130060B05Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1932407
    NCBI Gene: 108013
  • Gene Overview
    MyGene.info: CELF4
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr18:25477632-25754157 bp, - strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      276526 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 18, 13.92 cM, cytoband B1
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    CELF4, CUGBP Elav-like family member 4
  • Vertebrate Orthologs
    8
  • Human Ortholog
    CELF4, CUGBP Elav-like family member 4
    Orthology source: HomoloGene, HGNC
  • Synonyms
    BRUNOL4, CELF-4
  • Links
    NCBI Gene ID: 56853
    neXtProt AC: NX_Q9BZC1
    UniProt: Q9BZC1

  • Chr Location
    18q12.2; chr18:37243040-37566052 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    22 phenotypes from 2 alleles in 8 genetic backgrounds
    1 images
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit neonatal lethality, shortened life span dependent on genetic background, and seizures. Mice heterozygous for a null allele exhibit complex seizures and abnormal body weights depending on age.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000024268 Ensembl Gene Model | MGI Sequence Detail 276526 C57BL/6J ±  kb
    transcript ENSMUST00000115816 Ensembl | MGI Sequence Detail 3995 Not Applicable  
    polypeptide ENSMUSP00000111483 Ensembl | MGI Sequence Detail 504 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      583 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 23
      Genomic 1
      cDNA 12
      Primer pair 8
      Other 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2442678, MGI:2444528
    References
    more
    • Summaries
      All 48
      Developmental Gene Expression 8
      Gene Ontology 8
      Phenotypes 14
    • Earliest
      J:74955 Good PJ, et al., A family of human RNA-binding proteins related to the Drosophila Bruno translational regulator. J Biol Chem. 2000 Sep 15;275(37):28583-92
    • Latest
      J:261316 Perez-Garcia V, et al., Placentation defects are highly prevalent in embryonic lethal mouse mutants. Nature. 2018 Mar 22;555(7697):463-468

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
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    last database update
    05/15/2018
    MGI 6.12
    The Jackson Laboratory