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Dbn1
Gene Detail
 Symbol
Name
ID
Dbn1
drebrin 1
MGI:1931838
Synonyms drebrin A, drebrin E2
Feature Type protein coding gene
Genetic Map
Chromosome 13
30.06 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr13:55473429-55488111 bp, - strand
From VEGA annotation of GRCm38

  14683 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3236  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Dbn1

Human
homologs
Human Homolog DBN1, drebrin 1
NCBI Gene ID 1627
neXtProt AC  NX_Q16643
Human Synonyms  D0S117E
Human Chr (Location)  5q35.3; chr5:177456613-177473693 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Targeted(5)
Genomic Mutations involving Dbn1 (1)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice have defects in cued conditioning behavior.
 
Alleles Annotated to Human Diseases(1)   
Interactions
Dbn1 interacts with 165 markers (Mir15a, Mir17, Mir18, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (20 annotations)
Process actin filament organization, cell communication by chemical coupling, ...
Component actin cytoskeleton, cell, ...
Function actin binding, profilin binding, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (25)    Tissues (11)   
Theiler Stages: 25, 28
Assay TypeResults
RT-PCR 25
cDNA source data(149)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(152) cDNA(149) Primer pair(3)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000017050 (Evidence)
Ensembl Gene ModelENSMUSG00000034675 (Evidence)
Entrez Gene56320 (Evidence)
UniGene19016
DFCITC1576758, TC1594702, TC1595165, TC1668236, TC1673399
DoTSDT.101397278, DT.101397279, DT.110962682, DT.532411, DT.94348109, DT.97340092
NIA Mouse Gene IndexU034816
Consensus CDS ProjectCCDS36677.1, CCDS49273.1, CCDS49274.1
International Mouse Knockout Project StatusDbn1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000017050 VEGA Gene Model | MGI Sequence Detail 14683 C57BL/6J ±  kb
transcript OTTMUST00000041296 VEGA | MGI Sequence Detail 3078 Not Applicable 
polypeptide OTTMUSP00000018533 VEGA | MGI Sequence Detail 706 Not Applicable 

For the selected sequences
All sequences(66) RefSeq(8) UniProt(3)
Polymorphisms PCR(1) : SNPs within 2kb(8 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002108 Actin-binding, cofilin/tropomyosin type
Protein Ontology PR:000006296 drebrin
References (Earliest) J:76483 Jin M, et al., A novel, brain-specific mouse drebrin: cDNA cloning, chromosomal mapping, genomic structure, expression, and functional characterization. Genomics. 2002 May;79(5):686-92
(Latest) J:207976 Li Q, et al., The splicing regulator PTBP2 controls a program of embryonic splicing required for neuronal maturation. Elife. 2014;3:e01201
All references(39)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/23/2014
MGI 5.19
The Jackson Laboratory