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Dbn1
Gene Detail
Symbol

Name
ID
Dbn1
drebrin 1
MGI:1931838
Synonyms
drebrin A, drebrin E2
Feature Type
protein coding gene
Genetic Map
Chromosome 13
30.06 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr13:55473429-55488168 bp, - strand
From VEGA annotation of GRCm38

  14740 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3236  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: DBN1
Gene Tree: Dbn1

Human
homologs
DBN1, drebrin 1
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 1627
neXtProt AC: NX_Q16643

Human Synonyms: D0S117E

Human Chr (Location): 5q35.3; chr5:177456613-177480336 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Targeted(5)
Genomic Mutations involving Dbn1 (1)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygous null mice have defects in cued conditioning behavior.
 
Mutations Annotated to Human Diseases (1)    Phenotype Images(1)
Interactions
Dbn1 interacts with 165 markers (Mir15a, Mir17, Mir18, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (24 annotations)
Process actin filament organization, cell communication by chemical coupling, ...
Component actin cytoskeleton, cell, ...
Function actin binding, profilin binding, ...
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (25)    Tissues (11)    Tissue x Stage Matrix (view)
Assay TypeResults
RT-PCR 25
cDNA source data(149)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase dbn1    NEW 
Molecular
reagents
All nucleic(152) cDNA(149) Primer pair(3)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000017050 (Evidence)
Ensembl Gene Model ENSMUSG00000034675 (Evidence)
Entrez Gene 56320 (Evidence)
UniGene 19016
DFCI TC1673399, TC1595165, TC1576758, TC1594702, TC1668236
DoTS DT.101397278, DT.94348109, DT.532411, DT.110962682, DT.101397279, DT.97340092
NIA Mouse Gene Index U034816
Consensus CDS Project CCDS36677.1, CCDS49273.1, CCDS49274.1
International Mouse Phenotyping Consortium Status Dbn1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000017050 VEGA Gene Model | MGI Sequence Detail 14740 C57BL/6J ±  kb
transcript OTTMUST00000041296 VEGA | MGI Sequence Detail 3078 Not Applicable 
polypeptide OTTMUSP00000018533 VEGA | MGI Sequence Detail 706 Not Applicable 

For the selected sequences
All sequences(66) RefSeq(8) UniProt(3)
Polymorphisms
PCR(1) : SNPs within 2kb(8 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002108 Actin-binding, cofilin/tropomyosin type
Protein Ontology PR:000006296 drebrin
References
(Earliest) J:76483 Jin M, et al., A novel, brain-specific mouse drebrin: cDNA cloning, chromosomal mapping, genomic structure, expression, and functional characterization. Genomics. 2002 May;79(5):686-92
(Latest) J:222010 Ao X, et al., Expression of Dbn1 during mouse brain development and neural stem cell differentiation. Biochem Biophys Res Commun. 2014 Jun 20;449(1):81-7
All references(42)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/28/2015
MGI 5.22
The Jackson Laboratory