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Chst5 Gene Detail
Summary
  • Symbol
    Chst5
  • Name
    carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 5
  • Synonyms
    GST-4, I-GlcNAc6ST
  • Feature Type
    protein coding gene
  • IDs
    MGI:1931825
    NCBI Gene: 56773
  • Gene Overview
    MyGene.info: CHST6
Location & Maps
more
  • Sequence Map
    Chr8:111889135-111910199 bp, - strand
  • From NCBI annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      21065 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 8, 58.11 cM, cytoband E1
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    CHST6, carbohydrate sulfotransferase 6
  • Vertebrate Orthologs
    10
  • Human Ortholog
    CHST6, carbohydrate sulfotransferase 6
    Orthology source: HomoloGene
  • Synonyms
    MCDC1
  • Links
    NCBI Gene ID: 4166
    neXtProt AC: NX_Q9GZX3

  • Chr Location
    16q22; chr16:75473124-75495434 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human CHST6 associations

Human Disease Mouse Models
       Macular Dystrophy, Corneal; MCD   OMIM: 217800
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    5 phenotypes from 2 alleles in 2 genetic backgrounds
    2 images
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    48
  • Gene trapped
    43
  • Targeted
    5
  • Incidental Mutations
    APF , CvDC
Homozygous mutation of this gene results in thinner corneas that show abnormally close collagen fibrillar packing.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 56773 NCBI Gene Model | MGI Sequence Detail 21065 C57BL/6J ±  kb
transcript NM_019950 RefSeq | MGI Sequence Detail 1935 C57BL/6  
polypeptide Q9QUP4 UniProt | EBI | MGI Sequence Detail 395 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    163 from dbSNP Build 142
Protein
Information
less
  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000005479 carbohydrate sulfotransferase 6
  • EC
  • InterPro Domains
    IPR016469 Carbohydrate sulfotransferase
    IPR027417 P-loop containing nucleoside triphosphate hydrolase
    IPR000863 Sulfotransferase domain
Molecular
Reagents
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  • All nucleic 10
    cDNA 8
    Other 2

    Microarray probesets 3
Other
Accession IDs
less
MGI:2142470
References
more
  • Summaries
    All 35
    Developmental Gene Expression 2
    Gene Ontology 7
    Phenotypes 10
  • Earliest
    J:57776 Lee JK, et al., Cloning and characterization of a mammalian N-acetylglucosamine-6-sulfotransferase that is highly restricted to intestinal tissue. Biochem Biophys Res Commun. 1999 Sep 24;263(2):543-9
  • Latest
    J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
08/23/2016
MGI 6.05
The Jackson Laboratory