Chst5
Gene Detail

Symbol Name ID

Chst5 carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 5 MGI:1931825

Synonyms

GST-4, I-GlcNAc6ST

Feature Type

protein coding gene

Genetic Map

Chromosome 8

58.11 cM, cytoband E1
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr8:111889135-111910199 bp, - strand From NCBI annotation of GRCm38   21065 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:56927  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: carbohydrate sulfotransferase
Gene Tree: Chst5

Human homologs

Human Homolog		CHST6, carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 6
NCBI Gene ID		4166
neXtProt AC		NX_Q9GZX3
Human Synonyms		MCDC1
Human Chr (Location)		16q22; chr16:75507022-75528926 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human CHST6

Alleles and phenotypes

All alleles(47) : Targeted(4) Gene trapped(43)
 

Homozygous mutation of this gene results in thinner corneas that show abnormally close collagen fibrillar packing.

 
Phenotype Images(2)

Gene Ontology (GO) classifications

All GO classifications: (15 annotations)

Process	carbohydrate metabolic process, keratan sulfate biosynthetic process, ...
Component	Golgi membrane, integral to membrane, ...
Function	N-acetylglucosamine 6-O-sulfotransferase activity, sulfotransferase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (2 records)
Data Summary: Results (110)    Tissues (98)    Images (17)
Theiler Stages: 22, 23

Assay Type	Results
RNA in situ	110

cDNA source data(8)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(10) cDNA(8) Other(2)
Microarray probesets(3)

Other database links

Ensembl Gene Model	ENSMUSG00000031952 (Evidence)
Entrez Gene	56773 (Evidence)
UniGene	432506
DFCI	TC1585393
DoTS	DT.527549
NIA Mouse Gene Index	U030272
EC	2.8.2.-
Consensus CDS Project	CCDS22682.1
International Mouse Knockout Project Status	Chst5

Sequences

Length	Strain/Species
genomic	56773	NCBI Gene Model | MGI Sequence Detail	21065	C57BL/6J
transcript	NM_019950	RefSeq | MGI Sequence Detail	1935	C57BL/6
polypeptide	Q9QUP4	UniProt | EBI | MGI Sequence Detail	395	Not Applicable

All sequences(14) RefSeq(2) UniProt(1)

Polymorphisms

SNPs(40 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR016469	Carbohydrate sulfotransferase
InterPro	IPR000863	Sulfotransferase domain
Protein Ontology	PR:000005478	carbohydrate sulfotransferase 5

Graphical View of Protein Domain Structure

References

(Earliest) J:57776 Lee JK, et al., Cloning and characterization of a mammalian N-acetylglucosamine-6-sulfotransferase that is highly restricted to intestinal tissue. Biochem Biophys Res Commun. 1999 Sep 24;263(2):543-9
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(34)

Other accession IDs

MGI:2142470