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Scyl1 Gene Detail
Summary
  • Symbol
    Scyl1
  • Name
    SCY1-like 1 (S. cerevisiae)
  • Synonyms
    2810011O19Rik, mdf, mfd, Ntkl, p105
  • Feature Type
    protein coding gene
  • IDs
    MGI:1931787
    NCBI Gene: 78891
  • Gene Overview
    MyGene.info: SCYL1
  • Alliance
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:5758427-5771401 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 19, 4.34 cM
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    113 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1931787
protein coding gene Chr19:5758422-5771414 (-)
129S1/SvImJ MGP_129S1SvImJ_G0024728
protein coding gene Chr19:2748597-2761571 (-)
A/J MGP_AJ_G0024694
protein coding gene Chr19:2598547-2611527 (-)
AKR/J MGP_AKRJ_G0024667
protein coding gene Chr19:2667009-2681469 (-)
BALB/cJ MGP_BALBcJ_G0024694
protein coding gene Chr19:2593793-2606927 (-)
C3H/HeJ MGP_C3HHeJ_G0024462
protein coding gene Chr19:2688561-2701481 (-)
C57BL/6NJ MGP_C57BL6NJ_G0025141
protein coding gene Chr19:2815956-2830116 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0022571
protein coding gene Chr19:2507845-2520522 (-)
CAST/EiJ MGP_CASTEiJ_G0023934
protein coding gene Chr19:2702657-2716092 (-)
CBA/J MGP_CBAJ_G0024434
protein coding gene Chr19:2945392-2958323 (-)
DBA/2J MGP_DBA2J_G0024561
protein coding gene Chr19:2594185-2607139 (-)
FVB/NJ MGP_FVBNJ_G0024527
protein coding gene Chr19:2590770-2604409 (-)
LP/J MGP_LPJ_G0024647
protein coding gene Chr19:2720008-2734752 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0024557
protein coding gene Chr19:2781250-2794211 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0025189
protein coding gene Chr19:2685556-2700361 (-)
PWK/PhJ MGP_PWKPhJ_G0023680
protein coding gene Chr19:2618148-2631484 (-)
SPRET/EiJ MGP_SPRETEiJ_G0023485
protein coding gene Chr19:2673688-2688541 (-)
WSB/EiJ MGP_WSBEiJ_G0023996
protein coding gene Chr19:2696396-2709278 (-)



Homology
more
  • Human Ortholog
    SCYL1, SCY1 like pseudokinase 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    SCYL1, SCY1 like pseudokinase 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    GKLP, HT019, NKTL, NTKL, P105, SCAR21, TAPK, TEIF, TRAP
  • Links
    NCBI Gene ID: 57410
    neXtProt AC: NX_Q96KG9
    UniProt: Q96KG9

  • Chr Location
    11q13.1; chr11:65525065-65538711 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 6947
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;2 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: SCYL1
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with Scyl1 mouse models; 1 with human SCYL1 associations

Human Disease Mouse Models
      
IDs
View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    58 phenotypes from 3 alleles in 6 genetic backgrounds
    11 phenotypes from multigenic genotypes
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a spontaneous mutation or a knock-out allele develop a motoneuron disease characterized by gait ataxia, reduced grip strength, tremors, progressive hindlimb paralysis, muscular atrophy, and motoneuron degeneration.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000024941 Ensembl Gene Model | MGI Sequence Detail 12975 C57BL/6J ±  kb
    transcript ENSMUST00000025890 Ensembl | MGI Sequence Detail 2637 Not Applicable  
    polypeptide ENSMUSP00000025890 Ensembl | MGI Sequence Detail 806 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 9
      cDNA 9

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-12162, MGD-MRK-12209, MGI:1926141, MGI:2147799, MGI:96948
    References
    more
    • Summaries
      All 49
      Developmental Gene Expression 2
      Diseases 1
      Gene Ontology 5
      Phenotypes 16
    • Earliest
      J:4479 Womack JE, et al., Muscle deficient, a new mutation in the mouse. J Hered. 1980;71:68
    • Latest
      J:262629 Kuliyev E, et al., Overlapping Role of SCYL1 and SCYL3 in Maintaining Motor Neuron Viability. J Neurosci. 2018 Feb 7;

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    12/04/2018
    MGI 6.13
    The Jackson Laboratory