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Smpdl3a Gene Detail
Summary
  • Symbol
    Smpdl3a
  • Name
    sphingomyelin phosphodiesterase, acid-like 3A
  • Synonyms
    0610010C24Rik, ASM3A, ASML3A
  • Feature Type
    protein coding gene
  • IDs
    MGI:1931437
    NCBI Gene: 57319
  • Alliance
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:57794544-57811830 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 10, 29.25 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    101 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1931437
protein coding gene Chr10:57794335-57811830 (+)
129S1/SvImJ MGP_129S1SvImJ_G0017242
protein coding gene Chr10:57172740-57197075 (+)
A/J MGP_AJ_G0017218
protein coding gene Chr10:55504150-55521553 (+)
AKR/J MGP_AKRJ_G0017178
protein coding gene Chr10:56663836-56681384 (+)
BALB/cJ MGP_BALBcJ_G0017180
protein coding gene Chr10:55614987-55633471 (+)
C3H/HeJ MGP_C3HHeJ_G0017002
protein coding gene Chr10:56892493-56911166 (+)
C57BL/6NJ MGP_C57BL6NJ_G0017638
protein coding gene Chr10:58952444-58974010 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0015331
protein coding gene Chr10:52340922-52360869 (+)
CAST/EiJ MGP_CASTEiJ_G0016575
protein coding gene Chr10:56837354-56858413 (+)
CBA/J MGP_CBAJ_G0016974
protein coding gene Chr10:61422211-61441543 (+)
DBA/2J MGP_DBA2J_G0017079
protein coding gene Chr10:54845384-54863705 (+)
FVB/NJ MGP_FVBNJ_G0017074
protein coding gene Chr10:54088835-54108127 (+)
LP/J MGP_LPJ_G0017154
protein coding gene Chr10:57273751-57293099 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0017103
protein coding gene Chr10:63636721-63658570 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0017675
protein coding gene Chr10:56482857-56500920 (+)
PWK/PhJ MGP_PWKPhJ_G0016356
protein coding gene Chr10:54629276-54647073 (+)
SPRET/EiJ MGP_SPRETEiJ_G0016142
protein coding gene Chr10:56142982-56162376 (+)
WSB/EiJ MGP_WSBEiJ_G0016640
protein coding gene Chr10:56682287-56701896 (+)



Homology
more
  • Human Ortholog
    SMPDL3A, sphingomyelin phosphodiesterase acid like 3A
  • Vertebrate Orthologs
    10
  • Human Ortholog
    SMPDL3A, sphingomyelin phosphodiesterase acid like 3A
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ASM3A, ASML3a, yR36GH4.1
  • Links
    NCBI Gene ID: 10924
    neXtProt AC: NX_Q92484
    UniProt: Q92484

  • Chr Location
    6q22.31; chr6:122787180-122809720 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 57319 NCBI Gene Model | MGI Sequence Detail 17287 C57BL/6J ±  kb
    transcript NM_020561 RefSeq | MGI Sequence Detail 1791 C57BL/6  
    polypeptide P70158 UniProt | EBI | MGI Sequence Detail 445 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 109
      cDNA 108
      Primer pair 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:1917586, MGI:2143639
    References
    more
    • Summaries
      All 44
      Developmental Gene Expression 3
      Gene Ontology 8
      Phenotypes 9
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:231225 Gorelik A, et al., Structural Basis for Nucleotide Hydrolysis by the Acid Sphingomyelinase-like Phosphodiesterase SMPDL3A. J Biol Chem. 2016 Mar 18;291(12):6376-85

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    03/13/2019
    MGI 6.13
    The Jackson Laboratory