Sequence Detail

ID/Version

P70158 Q3U8C2 (UniProt | EBI)

Last sequence update: 2011-07-27
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Cyclic GMP-AMP phosphodiesterase SMPDL3A {ECO:0000305}; Short=2',3'-cGAMP phosphodiesterase SMPDL3A {ECO:0000305}; EC=3.1.4.- {ECO:0000250|UniProtKB:Q92484};AltName: Full=Acid sphingomyelinase-like phosphodiesterase 3a;

Provider

SWISS-PROT

Sequence

Polypeptide 445 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Smpdl3a	sphingomyelin phosphodiesterase, acid-like 3A	28	98	3	9

Sequence references in MGI

J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:224870 Heinz LX, et al., The Lipid-Modifying Enzyme SMPDL3B Negatively Regulates Innate Immunity. Cell Rep. 2015 Jun 30;11(12):1919-28
J:230619 Traini M, et al., Sphingomyelin phosphodiesterase acid-like 3A (SMPDL3A) is a novel nucleotide phosphodiesterase regulated by cholesterol in human macrophages. J Biol Chem. 2014 Nov 21;289(47):32895-913
J:231225 Gorelik A, et al., Structural Basis for Nucleotide Hydrolysis by the Acid Sphingomyelinase-like Phosphodiesterase SMPDL3A. J Biol Chem. 2016 Mar 18;291(12):6376-85
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:342622 Hou Y, et al., SMPDL3A is a cGAMP-degrading enzyme induced by LXR-mediated lipid metabolism to restrict cGAS-STING DNA sensing. Immunity. 2023 Nov 14;56(11):2492-2507.e10