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Hdac9
Gene Detail
 Symbol
Name
ID
Hdac9
histone deacetylase 9
MGI:1931221
Synonyms D030072B18Rik, Hdac7b, HDRP, Mitr
Feature Type protein coding gene
Genetic Map
Chromosome 12
15.06 cM, cytoband B2
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr12:34371503-34528889 bp, - strand
From Ensembl annotation of GRCm38

  157387 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:128578  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Gene Tree: Hdac9

Human
homologs
Human Homolog HDAC9, histone deacetylase 9
NCBI Gene ID 9734
neXtProt AC  NX_Q9UKV0
Human Synonyms  HD7, HD7b, HD9, HDAC, HDAC7, HDAC7B, HDAC9B, HDAC9FL, HDRP, MITR
Human Chr (Location)  7p21.1; chr7:18086942-18999512 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(2) : Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for disruptions in this gene display age dependent cardiac hypertrophy.
 
Interactions
Hdac9 interacts with 382 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (51 annotations)
Process B cell activation, B cell differentiation, ...
Component cytoplasm, histone deacetylase complex, ...
Function histone deacetylase activity, histone deacetylase activity (H3-K14 specific), ...
External Resources: FuncBase
Expression
Literature Summary: (13 records)
Data Summary: Results (78)    Tissues (27)    Images (8)
Theiler Stages: 2, 3, 17, 20, 22, 25, 28
Assay TypeResults
RNA in situ 32
Northern blot 8
RT-PCR 38
cDNA source data(10)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(12) cDNA(10) Primer pair(2)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000004698 (Evidence)
Entrez Gene79221 (Evidence)
DFCITC1583320, TC1599438, TC1602159, TC1610126, TC1627432, TC1697433
DoTSDT.101366212, DT.101704433, DT.55171813, DT.55229055, DT.91337273, DT.91595355, DT.94203436
NIA Mouse Gene IndexU033898
EC3.5.1.98
PDB1TQE
Consensus CDS ProjectCCDS36432.1
International Mouse Knockout Project StatusHdac9
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000004698 Ensembl Gene Model | MGI Sequence Detail 157387 C57BL/6J ±  kb
transcript ENSMUST00000110819 Ensembl | MGI Sequence Detail 4422 Not Applicable 
polypeptide ENSMUSP00000106443 Ensembl | MGI Sequence Detail 588 Not Applicable 

For the selected sequences
All sequences(70) RefSeq(36) UniProt(3)
Polymorphisms SNPs within 2kb(896 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR023801 Histone deacetylase domain
InterPro IPR024643 Histone deacetylase, glutamine rich N-terminal domain
InterPro IPR000286 Histone deacetylase superfamily
Protein Ontology PR:000008488 histone deacetylase 9
References (Earliest) J:60199 Zhou X, et al., Identification of a transcriptional repressor related to the noncatalytic domain of histone deacetylases 4 and 5. Proc Natl Acad Sci U S A. 2000 Feb 1;97(3):1056-61
(Latest) J:209031 Chatterjee TK, et al., HDAC9 knockout mice are protected from adipose tissue dysfunction and systemic metabolic disease during high-fat feeding. Diabetes. 2014 Jan;63(1):176-87
All references(61)
Other
accession IDs
MGI:2144976, MGI:3036283

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory