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Hdac9 Gene Detail
Summary
  • Symbol
    Hdac9
  • Name
    histone deacetylase 9
  • Synonyms
    D030072B18Rik, Hdac7b, HDRP, Mitr
  • Feature Type
    protein coding gene
  • IDs
    MGI:1931221
    NCBI Gene: 79221
  • Gene Overview
    MyGene.info: HDAC9
Location & Maps
more
  • Sequence Map
    Chr12:34047580-34917095 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      869516 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 12, 15.06 cM, cytoband B2
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    HDAC9, histone deacetylase 9
  • Vertebrate Orthologs
    8
  • Human Ortholog
    HDAC9, histone deacetylase 9
    Orthology source: HomoloGene, HGNC
  • Synonyms
    HD7, HD7b, HD9, HDAC, HDAC7, HDAC7B, HDAC9B, HDAC9FL, HDRP, MITR
  • Links
    NCBI Gene ID: 9734
    neXtProt AC: NX_Q9UKV0

  • Chr Location
    7p21.1; chr7:18086942-18999521 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    8 phenotypes from multigenic genotypes
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene display age dependent cardiac hypertrophy.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000061412 VEGA Gene Model | MGI Sequence Detail 869516 C57BL/6J ±  kb
transcript OTTMUST00000149903 VEGA | MGI Sequence Detail 3204 Not Applicable  
polypeptide OTTMUSP00000077741 VEGA | MGI Sequence Detail 1067 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    6970 from dbSNP Build 142
Protein
Information
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Molecular
Reagents
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  • All nucleic 12
    cDNA 10
    Primer pair 2

    Microarray probesets 3
Other
Accession IDs
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MGI:2144976, MGI:3036283
References
more
  • Summaries
    All 63
    Developmental Gene Expression 14
    Gene Ontology 14
    Phenotypes 15
  • Earliest
    J:60199 Zhou X, et al., Identification of a transcriptional repressor related to the noncatalytic domain of histone deacetylases 4 and 5. Proc Natl Acad Sci U S A. 2000 Feb 1;97(3):1056-61
  • Latest
    J:231711 Jin Z, et al., HDAC9 Inhibits Osteoclastogenesis via Mutual Suppression of PPARgamma/RANKL Signaling. Mol Endocrinol. 2015 May;29(5):730-8

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory