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Slurp1
Gene Detail
Symbol

Name
ID
Slurp1
secreted Ly6/Plaur domain containing 1
MGI:1930923
Synonyms
1110021N19Rik, ARS component B
Feature Type
protein coding gene
Genetic Map
Chromosome 15
34.26 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr15:74724318-74728034 bp, - strand
From VEGA annotation of GRCm38

  3717 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:10710  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

HCOP human homology predictions: SLURP1
Protein SuperFamily: Ly-6-like protein
Gene Tree: Slurp1

Human
homologs
SLURP1, secreted LY6/PLAUR domain containing 1
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 57152
neXtProt AC: NX_P55000

Human Synonyms: ANUP, ARS, ArsB, LY6LS, MDM

Human Chr (Location): 8q24.3; chr8:142740944-142742411 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human SLURP1

Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Radiation induced(1) Targeted(7)
Genomic Mutations involving Slurp1 (1)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice develop palmoplantar keratoderma, decreased body weight, and neuromuscular and metabolic phenotypes.
 
Human Diseases Modeled in Mice Using Slurp1 (1)    Mutations Annotated to Human Diseases (2)    Phenotype Images(2)
Interactions
Slurp1 interacts with 12 markers (Mir24-1, Mir24-2, Mir325, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (7 annotations)
Process locomotory behavior, negative regulation of keratinocyte proliferation, ...
Component extracellular exosome, extracellular region, ...
Function cytokine activity
External Resources: FuncBase
Expression
cDNA source data(5)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(6) cDNA(6)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000045148 (Evidence)
Ensembl Gene Model ENSMUSG00000022596 (Evidence)
Entrez Gene 57277 (Evidence)
DFCI TC1585021
NIA Mouse Gene Index U036286
Consensus CDS Project CCDS27528.1
International Mouse Phenotyping Consortium Status Slurp1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000045148 VEGA Gene Model | MGI Sequence Detail 3717 C57BL/6J ±  kb
transcript OTTMUST00000118635 VEGA | MGI Sequence Detail 2859 Not Applicable 
polypeptide OTTMUSP00000066216 VEGA | MGI Sequence Detail 110 Not Applicable 

For the selected sequences
All sequences(23) RefSeq(2) UniProt(2)
Polymorphisms
SNPs within 2kb(22 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001526 CD59 antigen
InterPro IPR018363 CD59 antigen, conserved site
InterPro IPR016054 Ly-6 antigen / uPA receptor -like
InterPro IPR027103 Secreted Ly-6/uPAR-related protein 1
Protein Ontology PR:000015251 secreted Ly-6/uPAR-related protein 1
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:210836 Adeyo O, et al., Palmoplantar keratoderma along with neuromuscular and metabolic phenotypes in Slurp1-deficient mice. J Invest Dermatol. 2014 Jun;134(6):1589-98
All references(29)
Disease annotation references (1)
Other
accession IDs
MGI:1915863, MGI:2145993

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/30/2015
MGI 5.22
The Jackson Laboratory