Phenotypes Associated with This Genotype

Genotype
MGI:5629846

• Allelic Composition: Slurp1^tm1.1Sgy/Slurp1^tm1.1Sgy
• Genetic Background: involves: 129 * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

limb grasping ( J:210836 )

• hindlimb clasping

abnormal gait ( J:210836 )

• mice drag hindlimbs and tail by 4 months of age

• while walking, mice have a lower pelvis and do not raise their tails

growth/size/body

decreased body weight ( J:210836 )

• 15-20% reduction in body weight at 9 weeks of age

integument

abnormal stratum corneum lipid matrix formation ( J:210836 )

• an abundance of small lipid droplets are seen in the stratum corneum

thick epidermis ( J:210836 )

• thickened epidermis in the paw skin

limbs/digits/tail

abnormal autopod morphology ( J:210836 )

• mice develop palmoplantar keratoderma

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
mal de Meleda		DOID:0060862	OMIM:248300	J:210836