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Osr2 Gene Detail
Summary
  • Symbol
    Osr2
  • Name
    odd-skipped related 2
  • Synonyms
    5430409I15Rik, Osr2A, Osr2B
  • Feature Type
    protein coding gene
  • IDs
    MGI:1930813
    NCBI Gene: 107587
  • Gene Overview
    MyGene.info: OSR2
Location & Maps
more
  • Sequence Map
    Chr15:35296098-35303304 bp, + strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      7207 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 15, 14.46 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    OSR2, odd-skipped related transciption factor 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    OSR2, odd-skipped related transciption factor 2
    Orthology source: HomoloGene, HGNC
  • Links
    NCBI Gene ID: 116039
    neXtProt AC: NX_Q8N2R0
    UniProt: Q8N2R0

  • Chr Location
    8q22.2; chr8:98944403-98952104 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 14200
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: OSR2
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    18 phenotypes from 5 alleles in 5 genetic backgrounds
    24 phenotypes from multigenic genotypes
    32 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice display neonatal lethality, cleft of the secondary palate, and thickened tympanic rings.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000022330 Ensembl Gene Model | MGI Sequence Detail 7207 C57BL/6J ±  kb
transcript ENSMUST00000022952 Ensembl | MGI Sequence Detail 1723 Not Applicable  
polypeptide ENSMUSP00000022952 Ensembl | MGI Sequence Detail 276 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    80 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 42
    cDNA 33
    Primer pair 6
    Other 3

    Microarray probesets 4
Other
Accession IDs
less
MGI:1918649
References
more
  • Summaries
    All 88
    Developmental Gene Expression 43
    Gene Ontology 7
    Phenotypes 32
  • Earliest
    J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
  • Latest
    J:237943 Jia S, et al., Bmp4-Msx1 signaling and Osr2 control tooth organogenesis through antagonistic regulation of secreted Wnt antagonists. Dev Biol. 2016 Dec 01;420(1):110-119

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/12/2017
MGI 6.10
The Jackson Laboratory