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Myh10
Gene Detail
Symbol

Name
ID
Myh10
myosin, heavy polypeptide 10, non-muscle
MGI:1930780
Synonyms
5730504C04Rik, 9330167F11Rik, Fltn, Fltn, mKIAA3005, Myhn2, Myhn-2, myosin IIB, Myosin IIB, NMHC-B, NMHC II-B, nonmuscle myosin heavy chain IIB, nonmuscle myosin heavy chain II-B, SMemb
Feature Type
protein coding gene
Genetic Map
Chromosome 11
41.95 cM, cytoband B3
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr11:68691559-68816632 bp, + strand
From VEGA annotation of GRCm38

  125074 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:55941  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: MYH10
Gene Tree: Myh10

Human
homologs
MYH10, myosin, heavy chain 10, non-muscle
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 4628
neXtProt AC: NX_P35580

Human Synonyms: NMMHCB, NMMHC-IIB

Human Chr (Location): 17p13; chr17:8474205-8631012 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(29) : Chemically induced (ENU)(1) Endonuclease-mediated(1) Gene trapped(17) Targeted(10)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Nullizygous mice show pre- and neonatal death, heart defects and hydrocephaly. Deletion of exon B1 disrupts migration of facial neurons, whereas deletion of exon B2 leads to Purkinje cell anomalies. Hypomorphs show hydrocephaly and defects in motor control, cerebellar foliation and neuron migration.
 
Phenotype Images(27)
Interactions
Myh10 interacts with 300 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (75 annotations)
Process actin cytoskeleton organization, actin filament-based movement, ...
Component actin cytoskeleton, actomyosin, ...
Function actin binding, actin-dependent ATPase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (42 records)
Data Summary: Results (400)    Tissues (46)    Images (34)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 41
RNA in situ 334
Western blot 25
cDNA source data(17)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase myh10 ; ZFIN myh10    NEW 
Molecular
reagents
All nucleic(19) Genomic(2) cDNA(17)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000005955 (Evidence)
Ensembl Gene Model ENSMUSG00000020900 (Evidence)
Entrez Gene 77579 (Evidence)
DFCI TC1646541, TC1615099, TC1586818, TC1573152
NIA Mouse Gene Index U257238, U043182
Consensus CDS Project CCDS24869.1
International Mouse Phenotyping Consortium Status Myh10
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000005955 VEGA Gene Model | MGI Sequence Detail 125074 C57BL/6J ±  kb
transcript OTTMUST00000039195 VEGA | MGI Sequence Detail 7759 Not Applicable 
polypeptide OTTMUSP00000017507 VEGA | MGI Sequence Detail 2013 Not Applicable 

For the selected sequences
All sequences(79) RefSeq(8) UniProt(10)
Polymorphisms
SNPs within 2kb(1480 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000048 IQ motif, EF-hand binding site
InterPro IPR001609 Myosin head, motor domain
InterPro IPR027401 Myosin-like IQ motif-containing domain
InterPro IPR004009 Myosin, N-terminal, SH3-like
InterPro IPR008989 Myosin S1 fragment, N-terminal
InterPro IPR002928 Myosin tail
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
Protein Ontology PR:000010821 myosin-10
References
(Earliest) J:14666 Eddinger TJ, et al., Expression of four myosin heavy chain isoforms with development in mouse uterus. Cell Motil Cytoskeleton. 1993;25(4):358-68
(Latest) J:220469 Grego-Bessa J, et al., Morphogenesis of the mouse neural plate depends on distinct roles of cofilin 1 in apical and basal epithelial domains. Development. 2015 Apr 1;142(7):1305-14
All references(115)
Other
accession IDs
MGD-MRK-12746, MGD-MRK-12750, MGI:1344335, MGI:1924454, MGI:1924829, MGI:97258

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory