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Myh10 Gene Detail
Summary
  • Symbol
    Myh10
  • Name
    myosin, heavy polypeptide 10, non-muscle
  • Synonyms
    5730504C04Rik, 9330167F11Rik, Fltn, Fltn, mKIAA3005, Myhn2, Myhn-2, myosin IIB, Myosin IIB, NMHC-B, NMHC II-B, nonmuscle myosin heavy chain IIB, nonmuscle myosin heavy chain II-B, SMemb
  • Feature Type
    protein coding gene
  • IDs
    MGI:1930780
    NCBI Gene: 77579
  • Gene Overview
    MyGene.info: MYH10
Location & Maps
more
  • Sequence Map
    Chr11:68691559-68816632 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      125074 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 41.95 cM, cytoband B3
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    MYH10, myosin, heavy chain 10, non-muscle
  • Vertebrate Orthologs
    10
  • Human Ortholog
    MYH10, myosin, heavy chain 10, non-muscle
    Orthology source: HomoloGene
  • Synonyms
    NMMHCB, NMMHC-IIB
  • Links
    NCBI Gene ID: 4628
    neXtProt AC: NX_P35580

  • Chr Location
    17p13; chr17:8474205-8631012 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 55941
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: MYH10
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    77 phenotypes from 10 alleles in 11 genetic backgrounds
    7 phenotypes from multigenic genotypes
    27 images
    36 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    30
  • Chemically induced (ENU)
    1
  • Chemically induced (other)
    1
  • Endonuclease-mediated
    1
  • Gene trapped
    17
  • Targeted
    10
  • Genomic Mutations
    1 involving Myh10
  • Incidental Mutations
Nullizygous mice show pre- and neonatal death, heart defects and hydrocephaly. Deletion of exon B1 disrupts migration of facial neurons, whereas deletion of exon B2 leads to Purkinje cell anomalies. Hypomorphs show hydrocephaly and defects in motor control, cerebellar foliation and neuron migration.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000005955 VEGA Gene Model | MGI Sequence Detail 125074 C57BL/6J ±  kb
transcript OTTMUST00000039195 VEGA | MGI Sequence Detail 7759 Not Applicable  
polypeptide OTTMUSP00000017507 VEGA | MGI Sequence Detail 2013 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    1469 from dbSNP Build 142
Protein
Information
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  • UniProt
    10 Sequences
  • InterPro Domains
    IPR000048 IQ motif, EF-hand binding site
    IPR001609 Myosin head, motor domain
    IPR027401 Myosin-like IQ motif-containing domain
    IPR004009 Myosin, N-terminal, SH3-like
    IPR008989 Myosin S1 fragment, N-terminal
    IPR002928 Myosin tail
    IPR027417 P-loop containing nucleoside triphosphate hydrolase
Molecular
Reagents
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  • All nucleic 19
    Genomic 2
    cDNA 17

    Microarray probesets 4
Other
Accession IDs
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MGD-MRK-12746, MGD-MRK-12750, MGI:1344335, MGI:1924454, MGI:1924829, MGI:97258
References
more
  • Summaries
    All 118
    Developmental Gene Expression 45
    Gene Ontology 24
    Phenotypes 36
  • Earliest
    J:14666 Eddinger TJ, et al., Expression of four myosin heavy chain isoforms with development in mouse uterus. Cell Motil Cytoskeleton. 1993;25(4):358-68
  • Latest
    J:227358 Thomas DG, et al., Non-muscle myosin IIB is critical for nuclear translocation during 3D invasion. J Cell Biol. 2015 Aug 17;210(4):583-94

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory