About   Help   FAQ
Bhlhe41
Gene Detail
 Symbol
Name
ID
Bhlhe41
basic helix-loop-helix family, member e41
MGI:1930704
Synonyms 6430520M22Rik, Bhlhb3, DEC2, Sharp1
Feature Type protein coding gene
Genetic Map
Chromosome 6
77.70 cM, cytoband G2-G3
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr6:145858243-145865558 bp, - strand
From VEGA annotation of GRCm38

  7316 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:137371  Vertebrate Homology Class
1 mouse; 1 rat

Gene Tree: Bhlhe41

Mutations,
alleles, and
phenotypes
All mutations/alleles(2) : Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for one knock-out allele exhibit delayed circadian phase. Mice homozygous for another knock-out allele exhibit impaired TH2 differentiation in response to numerous stimuli.
 
Interactions
Bhlhe41 interacts with 370 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (40 annotations)
Process circadian regulation of gene expression, entrainment of circadian clock, ...
Component nucleus, transcriptional repressor complex
Function bHLH transcription factor binding, DNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (158)    Tissues (142)    Images (33)
Theiler Stages: 11, 13, 15, 17, 19, 20, 22, 23, 24, 26, 28
Assay TypeResults
RNA in situ 140
RT-PCR 18
cDNA source data(32)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(33) cDNA(32) Primer pair(1)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000025458 (Evidence)
Ensembl Gene ModelENSMUSG00000030256 (Evidence)
Entrez Gene79362 (Evidence)
UniGene154529
DFCITC1585142, TC1608971, TC1665543, TC1678028
DoTSDT.488372, DT.55131354, DT.91566648, DT.94312629
NIA Mouse Gene IndexU028029, U260375
Consensus CDS ProjectCCDS20697.1, CCDS71860.1
International Mouse Knockout Project StatusBhlhe41
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000025458 VEGA Gene Model | MGI Sequence Detail 7316 C57BL/6J ±  kb
transcript OTTMUST00000062685 VEGA | MGI Sequence Detail 6133 Not Applicable 
polypeptide OTTMUSP00000030950 VEGA | MGI Sequence Detail 410 Not Applicable 

For the selected sequences
All sequences(49) RefSeq(6) UniProt(4)
Polymorphisms SNPs within 2kb(50 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
InterPro IPR003650 Orange
InterPro IPR018352 Orange subgroup
Protein Ontology PR:000004741 class E basic helix-loop-helix protein 41
References (Earliest) J:58265 Li J, et al., Leukaemia disease genes: large-scale cloning and pathway predictions [see comments]. Nat Genet. 1999 Nov;23(3):348-53
(Latest) J:209571 Goriki A, et al., A novel protein, CHRONO, functions as a core component of the mammalian circadian clock. PLoS Biol. 2014 Apr;12(4):e1001839
All references(45)
Other
accession IDs
MGI:1355306, MGI:2442594

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
09/09/2014
MGI 5.19
The Jackson Laboratory