Bhlhe41
Gene Detail

Symbol Name ID

Bhlhe41 basic helix-loop-helix family, member e41 MGI:1930704

Synonyms

6430520M22Rik, Bhlhb3, DEC2, Sharp1

Feature Type

protein coding gene

Genetic Map

Chromosome 6

77.70 cM, cytoband G2-G3
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr6:145858243-145865558 bp, - strand From VEGA annotation of GRCm38   7316 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:137371  Vertebrate Homology Class
1 mouse; 1 rat

Gene Tree: Bhlhe41

Mutations, alleles, and phenotypes

All mutations/alleles(2) : Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 

Mice homozygous for one knock-out allele exhibit delayed circadian phase. Mice homozygous for another knock-out allele exhibit impaired TH2 differentiation in response to numerous stimuli.

 

Interactions

Bhlhe41 interacts with 370 markers (Mir1a-1, Mir1a-2, Mir1b, ...)

View All

Gene Ontology (GO) classifications

All GO classifications: (39 annotations)

Process	circadian regulation of gene expression, entrainment of circadian clock, ...
Component	nucleus, transcriptional repressor complex
Function	bHLH transcription factor binding, DNA binding, ...

External Resources: FuncBase

Expression

Literature Summary: (4 records)

Data Summary: Results (158)    Tissues (142)    Images (33)
Theiler Stages: 11, 13, 15, 17, 19, 20, 22, 23, 24, 26, 28

Assay Type	Results
RNA in situ	140
RT-PCR	18

cDNA source data(32)
External Resources: Allen Institute   GEO   Expression Atlas

Molecular reagents

All nucleic(33) cDNA(32) Primer pair(1)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000025458 (Evidence)
Ensembl Gene Model	ENSMUSG00000030256 (Evidence)
Entrez Gene	79362 (Evidence)
UniGene	154529
DFCI	TC1585142, TC1608971, TC1665543, TC1678028
DoTS	DT.488372, DT.55131354, DT.91566648, DT.94312629
NIA Mouse Gene Index	U028029, U260375
Consensus CDS Project	CCDS20697.1, CCDS71860.1
International Mouse Knockout Project Status	Bhlhe41

Sequences

Length	Strain/Species
genomic	OTTMUSG00000025458	VEGA Gene Model | MGI Sequence Detail	7316	C57BL/6J
transcript	OTTMUST00000062685	VEGA | MGI Sequence Detail	6133	Not Applicable
polypeptide	OTTMUSP00000030950	VEGA | MGI Sequence Detail	410	Not Applicable

All sequences(49) RefSeq(6) UniProt(4)

Polymorphisms

SNPs within 2kb(50 from dbSNP Build 137)

Protein-related information

Resource	ID	Description
InterPro	IPR011598	Myc-type, basic helix-loop-helix (bHLH) domain
InterPro	IPR003650	Orange
InterPro	IPR018352	Orange subgroup
Protein Ontology	PR:000004741	class E basic helix-loop-helix protein 41

References

(Earliest) J:58265 Li J, et al., Leukaemia disease genes: large-scale cloning and pathway predictions [see comments]. Nat Genet. 1999 Nov;23(3):348-53
(Latest) J:209571 Goriki A, et al., A novel protein, CHRONO, functions as a core component of the mammalian circadian clock. PLoS Biol. 2014 Apr;12(4):e1001839
All references(44)

Other accession IDs

MGI:1355306, MGI:2442594