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Bhlhe41 Gene Detail
Summary
  • Symbol
    Bhlhe41
  • Name
    basic helix-loop-helix family, member e41
  • Synonyms
    6430520M22Rik, Bhlhb3, DEC2, Sharp1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1930704
    NCBI Gene: 79362
  • Gene Overview
    MyGene.info: BHLHE41
Location & Maps
more
  • Sequence Map
    Chr6:145858243-145865558 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      7316 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 77.70 cM, cytoband G2-G3
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    BHLHE41, basic helix-loop-helix family member e41
  • Vertebrate Orthologs
    2
  • Human Ortholog
    BHLHE41, basic helix-loop-helix family member e41
    Orthology source: HGNC
  • Synonyms
    BHLHB3, DEC2, hDEC2, SHARP1
  • Links
    NCBI Gene ID: 79365
    neXtProt AC: NX_Q9C0J9

  • Chr Location
    12p12.1; chr12:26120026-26125070 (-)  GRCh38.p2
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    13 phenotypes from 2 alleles in 2 genetic backgrounds
    2 phenotypes from multigenic genotypes
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    4
  • Targeted
    2
  • Transgenic
    2
  • Incidental Mutations
    Mutagenetix , APF
Mice homozygous for one knock-out allele exhibit delayed circadian phase. Mice homozygous for another knock-out allele exhibit impaired TH2 differentiation in response to numerous stimuli.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    39
  • GO References
    13
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    158
  • Tissues
    142
  • cDNA Data
    32
  • Literature Summary
    4
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000025458 VEGA Gene Model | MGI Sequence Detail 7316 C57BL/6J ±  kb
transcript OTTMUST00000062685 VEGA | MGI Sequence Detail 6133 Not Applicable  
polypeptide OTTMUSP00000030950 VEGA | MGI Sequence Detail 410 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    50 from dbSNP Build 142
Protein
Information
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  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000004741 class E basic helix-loop-helix protein 41
  • InterPro Domains
    IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
    IPR003650 Orange domain
Molecular
Reagents
less
  • All nucleic 33
    cDNA 32
    Primer pair 1

    Microarray probesets 4
Other
Accession IDs
less
MGI:1355306, MGI:2442594
References
more
  • Summaries
    All 43
    Developmental Gene Expression 4
    Gene Ontology 13
    Phenotypes 6
  • Earliest
    J:58265 Li J, et al., Leukaemia disease genes: large-scale cloning and pathway predictions [see comments]. Nat Genet. 1999 Nov;23(3):348-53
  • Latest
    J:223741 Shahmoradi A, et al., Enhanced memory consolidation in mice lacking the circadian modulators Sharp1 and -2 caused by elevated Igf2 signaling in the cortex. Proc Natl Acad Sci U S A. 2015 Jul 7;112(27):E3582-9
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/27/2016
MGI 6.05 		The Jackson Laboratory