Bhlhe41 MGI Mouse Gene Detail - MGI:1930704 - basic helix-loop-helix family, member e41

Bhlhe41 Gene Detail

Symbol

Bhlhe41
Name

basic helix-loop-helix family, member e41
Synonyms

6430520M22Rik, Bhlhb3, DEC2, Sharp1

Feature Type

protein coding gene
IDs

MGI:1930704
NCBI Gene: 79362
Gene Overview

MyGene.info: BHLHE41
Alliance

gene page

Sequence Map

Chr6:145858243-145865558 bp, - strand
From VEGA annotation of GRCm38

Mouse Genome Browser
Download
Sequence

7316 bp ± kb flank
Genome Browsers

VEGA | Ensembl | UCSC | NCBI

Genetic Map

Chromosome 6, 77.70 cM, cytoband G2-G3
Mapping Data

3 experiments

Human Ortholog

BHLHE41, basic helix-loop-helix family member e41

Vertebrate Orthologs

2

Human Ortholog

BHLHE41, basic helix-loop-helix family member e41
Orthology source: HGNC
Synonyms

BHLHB3, DEC2, hDEC2, SHARP1
Links

HGNC:16617

NCBI Gene ID: 79365

neXtProt AC: NX_Q9C0J9

UniProt: Q9C0J9
Chr Location

12p12.1; chr12:26120026-26125070 (-) GRCh38.p7

HomoloGene

Vertebrate Homology Class 137371
1 mouse;1 rat
HCOP

human homology predictions: BHLHE41
Gene Tree

Bhlhe41

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Phenotype Summary

13 phenotypes from 2 alleles in 2 genetic backgrounds
2 phenotypes from multigenic genotypes
7 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

4
Targeted

2
Transgenic

2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

5 strains or lines available

Mice homozygous for one knock-out allele exhibit delayed circadian phase. Mice homozygous for another knock-out allele exhibit impaired TH2 differentiation in response to numerous stimuli.

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All GO Annotations

39
GO References

13

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	receptor binding	RNA binding	transcription	transferase	transporter

Biological Process

nucleic acid-templated transcription	carbohydrate derivative metabolism	cell death	cell differentiation	cell proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

158
Tissues

142
cDNA Data

32
Literature Summary

4

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase bhlhe41

ZFIN bhlhe41

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Bhlhe41 interacts with 369 markers (Mir1a-1, Mir1a-2, Mir1b, ...) View All

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All Sequences

37
RefSeq

4
UniProt

4
CCDS

CCDS20697.1, CCDS71860.1
UniGene

154529

			Length	Strain/Species	Flank
genomic	OTTMUSG00000025458	VEGA Gene Model \| MGI Sequence Detail	7316	C57BL/6J	± kb
transcript	OTTMUST00000062685	VEGA \| MGI Sequence Detail	6133	Not Applicable
polypeptide	OTTMUSP00000030950	VEGA \| MGI Sequence Detail	410	Not Applicable

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SNPs within 2kb

50 from dbSNP Build 142

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UniProt

4 Sequences
Protein Ontology

PR:000004741 class E basic helix-loop-helix protein 41

(term hierarchy)
InterPro Domains

IPR036638 Helix-loop-helix DNA-binding domain superfamily

IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain

IPR003650 Orange domain

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All nucleic 33

cDNA 32

Primer pair 1

Microarray probesets 4

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MGI:1355306, MGI:2442594

Summaries

All 50

Developmental Gene Expression 4

Gene Ontology 13

Phenotypes 7
Earliest

J:58265 Li J, et al., Leukaemia disease genes: large-scale cloning and pathway predictions [see comments]. Nat Genet. 1999 Nov;23(3):348-53
Latest

J:258170 Kreslavsky T, et al., Essential role for the transcription factor Bhlhe41 in regulating the development, self-renewal and BCR repertoire of B-1a cells. Nat Immunol. 2017 Apr;18(4):442-455

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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